BACKGROUND: Idiopathic immune thrombocytopenia purpura is an autoimmune bleeding disorder that accounts for approximately one-third of clinical hemorrhagic diseases. Pathophysiologically, it involves a complicated imbalance in the immune system. OBJECTIVES: This study focuses on evaluating the levels of the immunomodulatory cytokines interleukin (IL)-35, interleukin-10, and transforming growth factor-β (TGF)-β in patients with refractory idiopathic immune thrombocytopenia undergoing treatment with romiplostim. MATERIALS AND METHODS: A cross-sectional study encompassed 78 individuals with idiopathic immune thrombocytopenia and conducted measurements of different immunomodulatory cytokines in response to different responses of idiopath

Survival analysis is widely applied to data that described by the length of time until the occurrence of an event under interest such as death or other important events. The purpose of this paper is to use the dynamic methodology which provides a flexible method, especially in the analysis of discrete survival time, to estimate the effect of covariate variables through time in the survival analysis on dialysis patients with kidney failure until death occurs. Where the estimations process is completely based on the Bayes approach by using two estimation methods: the maximum A Posterior (MAP) involved with Iteratively Weighted Kalman Filter Smoothing (IWKFS) and in combination with the Expectation Maximization (EM) algorithm. While the other

Abstract

Coronavirus has affected many people around the world and caused an increase in the number of hospitalized patients and deaths. The prediction factor may help the physician to classify whether the patient needs more medical attention to decrease mortality and worsening of symptoms. We aimed to study the possible relationship between C reactive protein level and the severity of symptoms and its effect on the prognosis of the disease. And determine patients who require closer respiratory monitoring and more aggressive supportive therapies to avoid poor prognosis. The data was gathered using medical record data, the patient's medical history, and the onset of symptoms, as well as a blood sample to test the

Abstract. One of the fibrewise micro-topological space is one in which the topology is decided through a group of fibre bundles, in comparison to the usual case in normal, fibrewise topological space. The micro-topological spaces draw power from their ability to be used in descriptions of a wide range of mathematical objects. These can be used to describe the topology of a manifold or even the topology of a group. Apart from easy manipulation, the fibrewise micro-topological spaces yield various mathematical applications, but the one being mentioned here is the possibility for geometric investigation of space or group structure. In this essay, we shall explain what fibrewise micro-topological spaces are, indicate why they are useful in math

We define and study new ideas of fibrewise topological space on D namely fibrewise multi-topological space on D. We also submit the relevance of fibrewise closed and open topological space on D. Also fibrewise multi-locally sliceable and fibrewise multi-locally section able multi-topological space on D. Furthermore, we propose and prove a number of statements about these ideas.

In this work we define and study new concept of fibrewise topological spaces, namely fibrewise soft topological spaces, Also, we introduce the concepts of fibrewise closed soft topological spaces, fibrewise open soft topological spaces, fibrewise soft near compact spaces and fibrewise locally soft near compact spaces.

In this paper we define and study new concepts of fibrewise topological spaces over B namely, fibrewise near topological spaces over B. Also, we introduce the concepts of fibrewise near closed and near open topological spaces over B; Furthermore we state and prove several Propositions concerning with these concepts.

Fibrewise topological spaces theory is a relatively new branch of mathematics, less than three decades old, arisen from algebraic topology. It is a highly useful tool and played a pivotal role in homotopy theory. Fibrewise topological spaces theory has a broad range of applications in many sorts of mathematical study such as Lie groups, differential geometry and dynamical systems theory. Moreover, one of the main objects, which is considered in fibrewise topological spaces theory is connectedness. In this regard, we of the present study introduce the concept of connected fibrewise topological spaces and study their main results.