Preferred Language
Articles
/
mhc57pIBVTCNdQwCqMNJ
Assessment Of Her-2/Neu Gene Amplification Status by Chromogenic in Situ Hybridization in Breast Cancer Patients with Equivocal 2+ Her-2/Neu Immunostaining and Its Relation to The Clinic Pathological Parameters
...Show More Authors

background: human epidermal growth factor receptor-2 (her2/neu) is related to growth factor receptors with alkaline kinase activity and it is regarded as important prognostic and therapeutic factor that can depended on in breast cancer therapy. HER2/neu expression by immunohistochemistry (IHC) is submitted to a great in terob server inconsistency. Subsequently additional confirmatory tests for assessment of gene alterations and amplification status are needed for patients with early or metastatic breast cancer. In situ hybridization techniques and specifically Chromogenic in situ hybridization (CISH) was arise as a practical, cost-effective, and alternative to fluorescent in situ hybridization in testing for gene alterationAims of the study: was to determinate her2/neu gene amplification in (27) breast cancer cases with equivocal her2/neu (2+) detected by IHC by using dual-color chromogenic in situ hybridization (CISH) method and to compare the results with clinic-pathological parameters of those patients like age, stage, grade, ER, PR and ki-67.Methods: twenty seven breast-cancer cases with equivocal HER2-IHC(2+) test results were prospectively collected and reanalyzedusing dual-color CISH (Zyto- Vision) detection kit for further identification of her2/neu gene amplification.Results: Cases with equivocal staining for her2/neu were about 27 cases; these cases were involved in chromogenic in situ hybridization technique to determine the status of her2/neu gene. After CISH study 12(44.4%)cases show her2/neu gene amplification (her2/neu/CEN17 ratio > 2.2).In15 (55.5%) cases out of 27 cases, no amplification of the HER2 gene was shown (her2/neu/CEN17 ratio <1.8).Conclusions: A significant proportion of patients with equivocal IHC(2+) test results show amplification of the HER2 gene by ISH.CISH method has the advantage of diagnosis of gene amplification and revealing tissue histopathology under light microscope.

View Publication Preview PDF
Quick Preview PDF
Publication Date
Fri Jan 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Experimental Investigation on Adsorption of Methyl orange Using eggshells as adsorbent Surface
...Show More Authors

The role of residues in the adsorption process for removing contaminants from their aqueous solution was highlighted in this study. The adsorption capacity of eggshells were used to remove the methyl orange dye from its aqueous solution. The highest dye adsorption was found to range between (62.30% to 62.33%). The results of using adsorption isotherms (Freundlich, Langmuir, and Temkin) have been revealed that the Freundlich model was followed and that the Langmuir model did not match, as well as the partial applicability of Temkin's model at temperatures (298,308,318) K. The process of adsorption is a physical one. Three kinetic models of the adsorption process were also used, with the results demonstrating the applicability of the pseud

... Show More
View Publication Preview PDF
Crossref (2)
Crossref
Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
Various Extracts of Some Medicinal Plants as Inhibitors for Beta-lactamase Activity
...Show More Authors

The inhibitory effect of acetone, ethanol, and aqueous extracts of ten medicinal plants on β-lactamase from Staphylococcus sciuri and Klebsiella pneumoniae was investigated in vitro by starch-iodine agar plate method. The results revealed the success of starch-iodine method for the detection of the inhibition of β-lactamase activity by the various extracts of each individual plant. The acetone extracts of Catharanthus roseus, Eucalyptus camaldulensis, and Schinus terebinthifolius induced an inhibitory effect on β-lactamase from Staphylococcus sciuri. On the other hand, acetone extracts from only Eucalyptus camaldulensis, and Schinus

... Show More
View Publication Preview PDF
Scopus (6)
Crossref (3)
Scopus Clarivate Crossref
Publication Date
Tue Jul 02 2013
Journal Name
Journal Of Baghdad College Of Dentistry
Local Drug Delivery Systems for Treating Periodontal Diseases: A Review of Literature
...Show More Authors

Publication Date
Sat Feb 27 2021
Journal Name
Iraqi Journal Of Science
Second Harmonic Generation of 266 nm Laser Beam Using BBO Nonlinear Crystal
...Show More Authors

Second harmonic generation (SHG) is a phenomenon observed in nonlinear optics that leads to frequency duplication for a high intensity laser incident on nonlinear crystal using BBO crystal. The SHG yield is achieved when the photons interact with a nonlinear optical material and effectively combine to form new photons with double frequency, and therefore double energy and half wavelength. This paper is concerned with the establishment of an SHG experiment to govern the process of producing half-wavelength laser beam from the input one. The theoretical effort was extended to compute the efficiency by using MATLAB software based on mathematical relationships. The values of the conversion maximum efficiencies, which were computed as a funct

... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Sun Nov 12 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
A Study of Some Cellulose Derivatives As Hydrogel For Control Drug Release
...Show More Authors

Neutral and semi-synthetic hydrophilic polymers are widely used

in pharmaceutical technology to fomlUlate as controlled release drugs

delivery systems ,cellulose derivatives is biocompatibilily, biodegradability , non-toxicity, its is a good candidate as drug carrier. In this study, polymers were used as cellulose derivatives like Methylcellulose (MC) & Soditun Carboxymetl1ylcellulose (NaCMC) as hydrogels for controlled delivery for two kinds of drugs, Cefotaxine

& Amoxycill ine trihydrate i n different media (Distilled water, Normal Saline & Buffer solution  PH=2). It has been shown that for sodium Carboxymethylcellulnse the drug release rate is more than the Mcthylcellulose and that the release

... Show More
View Publication Preview PDF
Publication Date
Thu Dec 29 2016
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
External Morphology of Planthopper Dictyophara iranica Germar 1833, ( Hemiptera: Dictyopharidae ) from Iraq
...Show More Authors

 The external morphology of planthoppers belong to the genus Dictyophara Germar 1833, has been described.    The study included detailed description of the external morphology of Dictyophara iranica Germar 1833.     External morphological characters of the head, thorax and their appendages were used. Those characters were supported by studying the male genitalia

View Publication Preview PDF
Publication Date
Fri Aug 28 2020
Journal Name
Iraqi Journal Of Science
Effects of Hematocrit on Blood Flow Through A Stenosed Human Carotid Artery
...Show More Authors

In this paper, the effects of hematocrit of red blood cells on blood flow through a stenosed human carotid artery was considered by taking blood as a Newtonian fluid. The governing equations on blood flow were derived. The mathematical content involved in the equations are the variables of interest such as number of stenosis , percentage of hematocrit  of red blood cells in the blood, flow rate, wall shear stress, and viscosity of the blood. Guided by medical data collected on the constraint of blood flow in stenosed human carotid arteries, the governing equations were used to check the effects of pressure gradient, wall shear stress, velocity, and volumetric flow rate of blood in the human carotid arteries. Also, the one-dimensiona

... Show More
View Publication Preview PDF
Scopus (1)
Crossref (1)
Scopus Crossref
Publication Date
Sat Dec 30 2023
Journal Name
Iraqi Journal Of Science
Simulation of Gaussian Pulses Propagation Through Single Mode Optical Fiber Using MATLAB
...Show More Authors

Computer-aided modeling and simulation software programs are essential tools
to predict how an optical communication component, link, or network will function
and perform. This paper aims to investigate the various effects on pulses
propagation in optical transmission systems utilizing the MATLAB program.
Dispersion and Attenuation effects are explored. The simulation of Gaussian pulses
propagation through single mode optical fiber, simplifies the design of optical
communication system and make the design process more efficient, less expensive,
and faster.

View Publication Preview PDF
Publication Date
Mon Aug 01 2022
Journal Name
Journal Of Engineering
Dynamic Behavior of Machine Foundations on layered sandy soil under Seismic Loadings
...Show More Authors

In this paper, a dynamic investigation is done for strip, rectangular and square machine foundation at the top surface of two-layer dry sand with various states (i.e., loose on medium sand and dense on medium sand). The dynamic investigation is performed numerically using finite element programming, PLAXIS 3D. The soil is expected as a versatile totally plastic material that complies with the Mohr-Coulomb yield criterion. A harmonic load is applied at the base with an amplitude of 6 kPa at a frequency of (2 and 6) Hz, and seismic is applied with acceleration – time input of earthquake hit Halabjah city north of Iraq. A parametric study is done to evaluate the influence of changing L/B ratio (Length=12,6,3 m and width=3 m), type of sand

... Show More
View Publication Preview PDF
Crossref (3)
Crossref
Publication Date
Thu Dec 31 2020
Journal Name
Political Sciences Journal
Islamic feminism is a discussion of paths for establishing an Islamic epistemology
...Show More Authors

If feminist philosophy in the context of feminist research focuses on how to produce an alternative knowledge and culture for women and forming anew awareness of their roles in the face of prevailing misconceptions then the topic of Islamic feminism is presented as a philosophical topic in the field of human knowledge to discuss how to produce an alternative knowledge of traditional knowledge prevailing in patriarchal societies to restore the balance of power and authority in the relationship between the sexes to create an effective feminist role in advocating for and defending womenś issues to achieve this Islamic feminism sought to establish an Islamic epistemology .

View Publication Preview PDF
Crossref