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Personalised Warfarin Dosing in Children Post-cardiac Surgery
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Abstract<p>Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating CYP2C9 and VKORC1 genotype information has been developed for children. The present prospective, observational study aimed to compare the model with conventional weight-based dosing. The study involved two groups of children post-cardiac surgery: Group 1 were warfarin naïve, in whom loading and maintenance doses were estimated using the model over a 6-month duration and compared to historical case-matched controls. Group 2 were already established on maintenance therapy and randomised into a crossover study comparing the model with conventional maintenance dosing, over a 12-month period. Five patients enrolled in Group 1. Compared to the control group, the median time to achieve the first therapeutic INR was longer (5 vs. 2 days), to stable anticoagulation was shorter (29.0 vs. 96.5 days), to over-anticoagulation was longer (15.0 vs. 4.0 days). In addition, median percentage of INRs within the target range (%ITR) and percentage of time in therapeutic range (%TTR) was higher; 70% versus 47.4% and 83.4% versus 62.3%, respectively. Group 2 included 26 patients. No significant differences in INR control were found between model and conventional dosing phases; mean %ITR was 68.82% versus 67.9% (<italic>p</italic> = 0.84) and mean %TTR was 85.47% versus 80.2% (<italic>p</italic> = 0.09), respectively. The results suggest model-based dosing can improve anticoagulation control, particularly when initiating and stabilising warfarin dosing. Larger studies are needed to confirm these findings.</p>
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Publication Date
Wed Jun 14 2023
Journal Name
Al-academy
The Cultural Identity in David Gentelman’s Works
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The study of cultural identity and its data in the designer’s work is considered a cultural nature to highlight the cultural identity and link it to the national culture of their country and society. It provides a reflection and translation of the society’s culture, traditions, social and economic dimensions, the natural environment, and scientific phenomena. Within meanings translated into a variety of methods, including expressive and realistic, which defines the designer’s relationship with his society and the national culture of his country and his connection with the civilization of the country.
The research problem came with the following question: What are the data of cultural identity in the work of designer David Gent

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Crossref
Publication Date
Wed Jun 07 2023
Journal Name
Journal Of Educational And Psychological Researches
Problems Facing University Students in Distance Learning
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The current study aims to examine the level of problems faced by university students in distance learning, in addition to identify the differences in these problems in terms of the availability of internet services, gender, college, GPA, interactions, academic cohort, and family economic status. The study sample consisted of (3172) students (57.3% females). The researchers developed a questionnaire with (32) items to measure distance learning problems in four areas: Psychological (9 items), academic (10 items), technological (7 items), and study environment (6 items). The responses are scored on a (5) point Likert Scale ranging from 1 (strongly disagree) to 5 (strongly agree). Means, standard deviations, and Multivariate Analysis of Vari

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Publication Date
Fri Jun 01 2012
Journal Name
Journal Of The College Of Languages (jcl)
Purgation in Evelyn Waugh's The Scarlet Woman
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The Scarlet Woman, Waugh's only screenplay and one of the least popular among his works, says more than it really does. Despite its  crudeness in terms of plot, acting, and directing, it conveys a serious message. On a limited scale, The Scarlet Woman might be regarded as Waugh's version of  Dante's Purgatorio.  Written when he was at Oxford,  it shows symptoms of  subconscious rejection of the wild life he led without God. Five years before his conversion to Catholicism, Waugh seems to have been waiting for purgation. This is his  design in The Scarlet Woman.

                As a satirist a

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Publication Date
Sun Jul 02 2017
Journal Name
Journal Of Educational And Psychological Researches
The Mental Health among Disabled in Baghdad
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The aims of this research are : 1. To measure mental health among disabled in Baghdad. 2. To identify the statistical differences in mental health among disabled in Baghdad according to gender. 3. To identify the statistical differences in mental health among disabled in Baghdad according to age. The scale of mental health (Aljbori&abdulhussin,2015) was adopted by the researcher, A purposely sample were selected of (60) disabled at Iraqi Alliance of Disabilitiv (IAD) in academic year 2015 to 2016. Where data have analyzed by SPSS. The results found. 1. The disabled characterized with good level of mental heath. 2. There was no significant differences between ganders 3. There are no significant differences between age. Results and rec

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Publication Date
Sun Jun 01 2008
Journal Name
Journal Of The College Of Languages (jcl)
Pain and pleasure in Ibn – Zaidoon poetry
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Pain and pleasure is when a human being feels pain because one of his sensesُ organs has extremely stressed itself. Where as pleasure is when someone indulges himself as much as he could and get away from anything that causes pain to himself and hurts it. The beauty of the poetic text appears when two contradictions occur together in the same poetic line, just like when two contradictions live together in life; they live and struggle in one poem. Contradictory duet is not something new poetry was based on this duet since it was found until this day. It forms the essential source from which meanings come, and the guide lines that drawn by the personal experience of the poet are formed from it.I preferred to study the duet of Ibn- Zaido
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Publication Date
Tue Apr 18 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Glomerulogenesis and Histomorphometeric in Mus musculus Embryo
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In mammals, the kidneys originate in an embryo from the mesoderm through three excretory organs, namely: Pronephros, Mesonephros, and Metanephros. After the formation of Metanephros is completed, the kidneys begin to form nephrogenesis through mesenchymal cells located at the tip of the ureteric bud, that contribute in the formation of glomerulus and Renal tubules. The stages of glomerulus formation in the embryo of albino mice at the age of 14 to 19 days of gestation were studied. It was obtained after the sacrifice of the expectant mother and the kidneys were excised from the embryos and fixed using Aqueous Bouin's solution, Microscopic slices with a thick

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Crossref
Publication Date
Fri Jan 01 2021
Journal Name
Environment Asia 14(1) 2021 13-22
Synoptic analysis of dust storm in Iraq
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In this study, the synoptic analysis of dust storm for spring and summertime in Iraq were investigated. The images for dust provided by NASA are used to emphasize the dust storm days, while the composite maps of wind vector and geopotential 850hPa are mapped to investigate the pressure and wind direction patterns appearing with the dust condition in the same days. Spring has more dust frequency than summertime, especially in May. The frontal type of dust storm is dominant on spring, the cold air pushes the warm air that picking up the sand to the air through the vertical wind, but the southwestern high-speed wind and drought condition were controlled on the dust in summer. The northwestern wind is the main factor that carries the dust for l

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Scopus (14)
Scopus
Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Trade and commodification in contemporary world ceramics
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The research deals with the global ceramic achievement within the international forums in the past decades. As follows، showing and presenting the aesthetic and intellectual values leading to common constants that establish international artistic studies that achieve the purpose of circulation and marketing of artworks. Contemporary global plastic art has witnessed a number of technical and social transformations and changes at the technical and pragmatic levels under the pressure of the changing and accelerating tide towards technical، cognitive، social and cultural concepts.
The second chapter came to the first topic: deliberative and commoditization، and the second topic: the deliberativeness of contemporary global ceramics.

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Crossref
Publication Date
Wed Jun 30 2010
Journal Name
Al-kindy College Medical Journal
Frozen Shoulder in Type 2 Diabetes Mellitus
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Background: Frozen shoulder affects 2-5% of the
general population, and around 10-30% of diabetic
patients. It affect mainly the non-dominant shoulder,
and has more incidence in patients with poor
glycemic control.
Objective: To detect the incidence of frozen
shoulder in type 2 diabetic patients attending the
Specialized Center for Endocrinology and Diabetes
in Baghdad.Patients and methods: One hundred
patients with frozen shoulder were included in the
study from a total number of 580 type 2 diabetics
over a period of six months. 70 patients were
females and 30 patient were males. All were
investigated for fasting blood
glucose and HbA1c.
Results: The non-dominant shoulder was
involved in

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Publication Date
Tue Jun 30 2009
Journal Name
Al-kindy College Medical Journal
Serum Zinc in Iraqi Acute Leukemic Patients
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Background: Leukemia is a group of malignant disorders
associated with increased numbers of blood white blood
cells. Acute leukemia occurs at all ages. Because zinc
influences many body systems and functions, zinc is an
essential nutrient for tissue growth, cellular division,
protein synthesis DNA and RNA replication it also ought to
play a critical role in the growth of tumor. In this study,
serum zinc was estimated in leukemic patients and
compared with healthy subjects.
Methods: The subjects in the present study were; fourtyfour depressed patients aged (14-48 year), thirty-one
apparently healthy subjects were selected as control group.
Their sex and age were comparable to that of patients.
Determin

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