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Cytotoxic potential activity of quercetin derivatives on MCF-7 breast cancer cell line

Many previous investigations have found quercetin to be a powerful antioxidant and antitumor flavonoid, but its poor bioavailability has limited its use. This current study investigated the effects of two newly synthesized Quercetin Schiff bases containing 2-amino thiadiazole-5-thiol (Q1), and its benzyl derivatives (Q2) on MCF-7 human breast cancer cells. Cell viability and apoptosis were assessed to determine the toxic effects of Q1 and Q2. Cytotoxicity valuation showed that both compounds inhibited MCF-7 cell growth, and lactate dehydrogenase (LDH) activity increased in a dose-dependent aspect compared to the control group. Comet assay results observed that Q1 and Q2 induce more serious DNA damage than the control (untreated cell); however, in all curried experiments, Q2 showed higher effects than Q1. Hence two synthesized quercetin Schiff bases can take action as a promising anticancer agent. Keywords: quercetin derivatives, Schiff base, breast cancer, MCF-7 Cytotoxic.

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Publication Date
Thu Jun 29 2017
Journal Name
College Of Islamic Sciences
The prohibition of cheating in the Sunnah of the Prophet

In The Name of Allah Most Gracious Most Merciful

Cheating is one of the forbidden actions and reprehensible morals that are forbidden by Islamic law, because it involves an assault on rights, whether they are the rights of God Almighty or the rights of God.

people, or self-rights, and because it involves harming others.

Since the Sunnah of the Prophet is the second source of Islamic law, many of the noble hadiths of the Prophet forbid and prohibit cheating.

This study sheds light on it.

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Publication Date
Fri Jun 30 2023
Journal Name
College Of Islamic Sciences
The Role Of Atheism In The Demolition Of Societal Security

The enemies of religion are still following the approach of undermining the Islamic faith in various ways through the diversity of methods of smear campaigns by raising suspicions to obliterate the Islamic identity and threaten security and stability of social life under the Islamic religion in Islamic societies, as we find that they have employed the doctrine of atheistic thought in order to distance people from the path of truth, distort the features of religion, destabilize psychological security and family stability, and thus destroy societal security by questioning the tolerant faith at times, and by raising suspicions at other times.

Hence, this research came to review the legal duty that requires Islamic scholars to protec

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Publication Date
Sun Jul 11 2021
Journal Name
Sustainable Civil Infrastructures
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Publication Date
Sun Dec 31 2023
Journal Name
Iraqi Geological Journal
Biostratigraphy of Shiranish Formation from Selected Wells, Central of Iraq

The Quantitative high-resolution planktonic foraminiferal analysis of the subsurface section in three selected wells in the Ajeel Oil Field (Aj-8, Aj-12, and Aj-15) in Tikrit Governorate, Central Iraq has revealed that Shiranish Formation deposited in Late Campanian- Latest Maastrichtian age. This formation consists mainly of marly and marly limestone yielding diverse planktonic foraminiferal assemblages and calcareous benthic foraminifera, with a total of 46 species that belong to 23 genera, Three zones and four subzones, which cover the Late Campanian to the Latest Maastrichtian, were identified based on the recorded planktonic foraminifera and their ranges. They are as follows:1. Globotruncana aegyptiaca Zone that dated to be Lat

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Publication Date
Thu Jun 30 2022
Journal Name
Iraqi Geological Journal
Assessment of the Contamination of Baghdad Soils with Lead Element

The present study aims to study the content and spatial distribution of lead (Pb) contamination in the soils of some Baghdad cities (Middle of Iraq). Twenty soil samples were randomly collected from different land-use in the studied area at a depth between 5 to 30 cm. Ten samples are collected from Al-Rissafa side areas (Adhamiya, Al-Wazeeria (Battery Manufacturer), Shikh Omer, Ziyouna, Karada, Shaab, Sadr city, Al-Za’franiya, Al-Dora expressway, and Alselikh ) and other ten samples are collected from Al-Krakh side areas Al-Dora, Al-Masafi junction, Al-Dora, Sayidia, Al-Salam university college, Al-Bayaa (Industrial District), Jehad, Amirya, Abu Ghraib, Al-hurriya, and Kadhimiya. The soil samples have been analyzed for the lead (P

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Publication Date
Mon Mar 08 2021
Journal Name
Baghdad Science Journal
Development of six-degree of freedom strapdown terrestrial INS algorithm

Many of accurate inertial guided missilc systems need to use more complex mathematical calculations and require a high speed processing to ensure the real-time opreation. This will give rise to the need of developing an effcint

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Publication Date
Wed Dec 30 2020
Journal Name
Iraqi Journal Of Science
Gastropods of Aptian- Cenomanian of Qamchuqa Formation from Northern Iraq

Gastropod species belonging to Qamchuqa Formation (Aptian-Cenomanian) in the North of Iraq are studied. These species  are Harpagodes nodosus (J.de C. Sowerby,1823),  Ampullina sp.1 (Hannaa and Furisch, 2011), Ampullina sp.2 (Hannaa and Furisch, 2011), Tylostoma pallaryi (Peron and Fourtau, 1904), Calliomphalus orientalis (Douville,1916), and Pyrgulifera (Meek, 1871). They are recorded in the Upper Cretaceous succession of Northern Iraq for the first time. Most of these species are internal moulds and not abundant at any stratigraphic level but irregularly scattered in the formation.

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Publication Date
Tue Jan 02 2018
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Hydatid cyst of the spine a study of 25 patients

Background: The spine is rarely affected by Hydatid cyst with incidence of (1%) of all cases. Despite
advances in imaging as well as surgical and medical treatment, spine Hydatid cyst (H.C) is associated
with high degree of morbidity, disability, and mortality.
Objective: To assess the clinical presentation, imaging of spine H.C. & the outcome of surgical
management regarding neurological recovery, recurrence and mortality.
Patients and Methods: This is a retrospective study of the 25 patients of spine Hydatid cyst during
five years period (Jan.2010 to Jan.2015), where diagnosed and treated at medical city. All patients
after proper clinical assessment, imaging and laboratory tests had underwent posterior decompr

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Publication Date
Wed Oct 07 2020
Journal Name
Journal Of Legal Sciences
The legal nature of nullity in a period of suspicion

Represents the period of suspicion period between start date stop payment and date of issuance of the rule of bankruptcy, and that behavior performed by the merchant debtor in this period is the behaviors suspicious. Once to stop the merchant debtor to pay its debts makes his action marred by disorder. as it may harm creditors or a preference for each of other because it feels along of bankruptcy or it may oversaw  so distrust legislator of his action in this period which is the most dangerous periods and most dangerous on creditors , the legislator stipulated that action issued by the debtor during this period should be null void the aim of the legislator is to protect the creditor community and that the non-exhaustion of the dispo

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Publication Date
Sun Feb 03 2019
Journal Name
Journal Of The College Of Education For Women
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