حسام سلمان جاسم
MSc
-
assistant professor
College of Education for Pure Sciences (Ibn Al-Haitham)
,
Department of Chemistry
[email protected]
Publication Date
Tue Nov 01 2022
Journal Name
Reports Of Biochemistry And Molecular Biology
(2)
Publication Date
Wed Mar 15 2023
Journal Name
Bionatura
Cytotoxic potential activity of quercetin derivatives on MCF-7 breast cancer cell line
Quercetin derivatives
Schiff base
breast cancer
MCF-7 Cytotoxic.
Many previous investigations have found quercetin to be a powerful antioxidant and antitumor flavonoid, but its poor bioavailability has limited its use. This current study investigated the effects of two newly synthesized Quercetin Schiff bases containing 2-amino thiadiazole-5-thiol (Q1), and its benzyl derivatives (Q2) on MCF-7 human breast cancer cells. Cell viability and apoptosis were assessed to determine the toxic effects of Q1 and Q2. Cytotoxicity valuation showed that both compounds inhibited MCF-7 cell growth, and lactate dehydrogenase (LDH) activity increased in a dose-dependent aspect compared to the control group. Comet assay results observed that Q1 and Q2 induce more serious DNA damage than the control (untreated cell
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