حسام سلمان جاسم
MSc
-
assistant professor
College of Education for Pure Sciences (Ibn Al-Haitham)
,
Department of Chemistry
[email protected]
Publication Date
Tue Nov 01 2022
Journal Name
Reports Of Biochemistry And Molecular Biology
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(2)
Publication Date
Wed Mar 15 2023
Journal Name
Bionatura
Cytotoxic potential activity of quercetin derivatives on MCF-7 breast cancer cell line
Quercetin derivatives
Schiff base
breast cancer
MCF-7 Cytotoxic.
Many previous investigations have found quercetin to be a powerful antioxidant and antitumor flavonoid, but its poor bioavailability has limited its use. This current study investigated the effects of two newly synthesized Quercetin Schiff bases containing 2-amino thiadiazole-5-thiol (Q1), and its benzyl derivatives (Q2) on MCF-7 human breast cancer cells. Cell viability and apoptosis were assessed to determine the toxic effects of Q1 and Q2. Cytotoxicity valuation showed that both compounds inhibited MCF-7 cell growth, and lactate dehydrogenase (LDH) activity increased in a dose-dependent aspect compared to the control group. Comet assay results observed that Q1 and Q2 induce more serious DNA damage than the control (untreated cell
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