Background:Ovulation constitutes a central event in ovarian physiology, and ovulatory dysfunction which is a relevant cause of female infertility. Mammalian ovulation is comparable to aninflammatory reaction since many of the molecules responsible for inducing the inflammatorycascade including PGs, leukotrienes and various cytokines have been describedin the ovary.
Objectives:This study was designed to compare between the effects of some NSAIDs(aspirin,diclofenac sodium and meloxicam)on the ovulatory process and the reproductive tract of female mice.
Materials and methods:Twenty four female mice were subdivided into 4groups (6 animals/group).The first received distilled water serve as control group, the second receivedaspirin (7.5 mg/kg.B.W) ,thethird received diclofenac sodium(2mg/kg.B.W) and the fourth received meloxicam(0.001mg/kg.B.W) subcutaneously at proestrous phase,Blood was collected at metestrousfor subsequent hormonal assay. The whole reproductive tract was excised out, examined, weighed and ova were flushed.
Results :Female mice that received 7.5 mg/kg.B.W of aspirin,showedenlarged, congested ovaries with cystic appearance and congested uteri with prominent blood vessels.Mice that received 2mg /kg.B.W.diclofenac and those received 0.01 mg/kg.B.W. meloxicam showed more congestion and more obvious cystic appearance of ovaries with uteri more bulky compared to controls that showed no congestion and no cystic appearance of the ovaries with thin non congested uteri.Highly significant (P < 0.001) increase in the ovarian weight and highly significant decrease in number of ova flushedwhile no significant changes (P > 0.05) were seen in the uterine weight nor in hormonal levels of LH and FSH between controls and each of animals that received aspirin, diclofenac and meloxicam respectively.
Conclusion:Short -term administration of low-dose (aspirin, diclofenac& meloxicam) to female mice at proestrous cause a highly significant increase in the ovarian weight with morphological changes of ovaries and uteri and a highly significant decrease in the ovulatory rate as compared to controls .Greater effect were produced by meloxicam with a lower dose compare to diclofenac and aspirin.
The Administrative agency enjoys certain privileges when issuing disciplinary actions on a public servant. As the only entity conferred with the authority to issue disciplinary action to actualize certain aims, like establishment of, or amendment or repealing of certain legal provisions. Public service is regarded as the most widespread sector due to the employer-employee working relationship between the administrative agency and the public servant. The aim of disciplinary action is to serve deterrent to the employee from committing similar offence in the future and guaranteeing of smooth running of the organization and effective delivery of work. Therefore, the administrative agency must commit to achieving this aim, without being outra
... Show MoreThe possible effect of the crude aqueous extract of soy bean seeds on some blood parameters (total count of red blood cells, white blood cell , (total and differential) blood platelates, packed cell volume and concentration of blood hemoglobin) was studied in 20 albino female mice which were allocated in four experimental groups (5 mice/group). The first group was orally treated with distilled water (control group) while the second, third and fourth group were given a concentration of 4%, 6% and 8% of the extract, respectively. At the end of the daily gavaging, which lasted for 4 weeks, the animals were killed, after recording their life body weight, and blood samples were collected from each mice to study the effect
... Show MoreThe present study aimed to investigate the histological changes of heart, lung, liver and kidney which caused by different concentrations (10, 20 and 40 mg/kg) of Ivabradine. Results of the study revealed some histological changes represented by aggregation of the lymphocytes around respiratory bronchioles of the lung. In the liver, the drug caused hepatocyte necrosis and infiltration of the lymphocytes. In Kidney, there are no histopathological modifications in the tissue after the animals treated with 10 mg\kg of Ivabradine. When the animals treated with Ivabradine drug at 20mg/kg of bw, dose showed vascular congestion between myocardial fibers of heart. Emphysematous c
... Show MoreIn the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addition to the control groups (F) exposed to fresh air only. A special inhalation chamber designed locally has been used to expose the animals. The exposure to brake pad particles was (2.228) µg/m³ for 30 min/day, 5 days/week for (4,8and12) weeks respectively.
The examination in group (A) of the histological sections of the lung showed the thickness of interalveolar septa. Also, a congestion of alveolar capillary was marked indicat
... Show MoreThe major countries have a lot of financial burdens as a result of their public expenditure to run their public facilities and implement their obligations in this regard. Countries may need to maximize their public revenues to meet their expenditures and increase the privatization policy according to the legal concept of selling their facilities or public companies. That the public revenues of the state and the shortcomings of the view of the pro-privatization as a means to increase the financial revenues of the state and the loss suffered by the States because of the fertility of its facilities and companies to the public and especially the elites of them because it will deprive them of the revenue fixed constant It flows into the state
... Show MoreCarbamazepine (CBZ) is one of many anticonvulsants used to treat trigeminal neuralgia and epilepsy. Antiepileptic drugs (AED`s) are the second most important class of medications that lead to hepatotoxicity and induced liver injury, this study was conducted to evaluate the effects of CBZ on the liver. A total of 40 female mice were taken and divided into four groups (A/treated for 14 days, B/ control, C/ treated for 30 days, D/ control), the drug was given as an oral suspension formula 100mg/5ml at dose 20 mg/kg/mouse via gastric gavage daily for 14 and 30 days. Statistical analysis revealed that there were no significant differences in the white female mice body weight (P>0.05) in the treated group for 14 days as well
... Show MoreMethotrexate (MTX) was used for treatment of malignancies and now is widely used in treatment of rheumatoid arthritis. In this research the evaluation of the effects of MTX on some liver enzymes and lipid profile was studied. Twenty four adult female mice divided into three groups (8 mice each). The first two groups were treated with MTX while the third group was used as a control. MTX was intraperitoneally given at 50 µg/ml and 75 µg/ml to the first and second groups respectively for 35 days ,whereas the control group was intraperitoneally injected with normal saline. The results showed a significant (p<0.05) increase in serum levels of glutamic oxaloacetate transaminase (GOT) , glutamic pyruric transaminase (GPT), Alkaline pho
... Show MoreThe right of the owner of the floor or apartment over his detached unit is a full ownership right, which simplifies to its owner the powers of use, exploitation and disposal, provided that the owner’s powers in the system of ownership of floors and apartments, as well as their adherence to the general restrictions of ownership, remain also restricted by agreement restrictions, the source of which is title deeds And the building bylaws, which are drawn up by the Building Owners Association.
Epilepsy is the most common neurological disorder after Alzheimer and other cerebrovascular diseases. Antiepileptic drugs (AED's) are one of the most important methods to prevent epileptic seizers. Antiepileptic drugs can cause damage to the liver which is the largest and most important glandular organ in the body with many other drugs. Carbamazepine (CBZ) is a known anticonvulsant that is widely used and known for a decade, it was used to treat trigeminal neuralgia, bipolar disorder and epilepsy and it can cause hepatotoxicity. In this study female white mice received CBZ suspension at a dose of 20 mg/kg/mouse via gastric gavage for 30 days, tissue samples were collected for scanning electron microscopy. We observed the adverse effects of
... Show MoreEffect of zinc chloride on the immune functions was studied in male albino mice aged 6-7 weeks. It was administrated orally (1ml) in three concentrations (0.5ppm, 1ppm, 2ppm) for 9 days. The results showed that the first concentration was not effective comparing with control while the second concentration increased the enhancement of immune system and the cell third one killed the mice 6 hours post administration, so we can conclude that the high dose of ZnCl2 could be harmful for all metabolism.