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Evaluation of the Role of Serum Malondialdehyde in the Pathogenesis of Diabetic Retinopathy

Background:  The most typical consequence of diabetes mellitus is diabetic retinopathy. An important part of the etiology of diabetes and diabetic retinopathy is played by oxidative stress. Malondialdehyde is a dialdehyde that is moderately toxic and is frequently used as a marker for oxidative stress as well as lipid peroxidation.                    

Objectives: To assess the serum malondialdehyde levels in diabetic patients with and those without retinopathy and to compare these levels to controls .In additions to, investigate the relationship between serum malondialdehyde level and long glycemic control, the glycated hemoglobin (HbA1c).

Patients and Methods: This case-control study included (120) individuals from 40 to 70 years of age. They were divided into three groups: Group 1: 40 type 2diabetic patients with retinopathy, Group 2 :40 type 2 diabetic patients without retinopathy, and Group 3 40 controls .The biochemical testes included fasting blood glucose measured by Cobas c 311 systems, glycated hemoglobinHbA1c measured by Cobas c 111 systems, and serum malondialdehyde (MDA) measured by enzyme linked immunosorbent assay (ELISA).

Results: A higer mean value of (MDA) was found serum diabetic patients with and without retinopathy as compared to control (p=0.0001). As well as a significantly higher mean value of serum (MDA)  in diabetic patients with retinopathy as compared to those without (p=0.0001).A significant positive correlation was found between serum(MDA)  and HbA1C in diabetic patient with retinopathy group (r=0.931,p=0.0001) .

Conclusion: Higher serum levels of malondialdehyde is an indicator of increased lipid peroxidation that may be involved in pathogeneses of retinopathy in uncontrolled type 2 diabetic patients.

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Publication Date
Wed Apr 11 2018
Journal Name
Acta Neuropathologica Communications
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Publication Date
Sun Dec 01 2013
Journal Name
Toxicon
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Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
Impact of replacing the old chicken and add soy protein in Alvezaawih qualities Barker beef

The purpose of this study was to determine the impact of added soy protein humidifier concentration of different ratios of bovine Alberkr mix that was to bring the old chicken shop pure beef in five ratios

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Publication Date
Thu Jun 30 2011
Journal Name
Al-kindy College Medical Journal
THE PREVALENCE AND CLINICAL SIGNIFICANCE OF PERINUCLEAR ANTINEUTROPHIL CYTOPLASMIC ANTIBODY IN PATIENTS WITH INDETERMINATE COLITIS

Background: Indeterminate colitis (IC), a term
originated by pathologists to characterize confounding
histopathlogic appearance of resected mucosa, has
become catch phrase for cases in which diagnostic
criteria at all levels elude classification as Crohn's
disease (CD) or ulcerative colitis (UC).
OBJECTIVES: evaluate the prevalence of pANCA
expression in the sera and its isotypes.
Patients and methods: PATIENTS GROUP
consisted of 60 patients (40 males and 20 females)
with indeterminate colitis and their age range was (19-
84 years). CONTROL GROUP consisted of 30 (15
males and 15 females) healthy volunteers and their
age range was (20- 66 years).
Antineutrophil cytoplasmic ( pANCA and cANCA)
te

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Publication Date
Fri Jan 01 2016
Journal Name
Journal Of Pharmaceutical, Chemical And Biological Sciences
Relationship between Chronic Hepatitis B Virus and Pathogenicity of Celiac Disease in the Iraqi Patients

To determine the relationship between chronic hepatitis B virus and autoimmune celiac disease, seventy five patients with chronic hepatitis B virus of ages (8-70) years have been investigated and compared with 50 healthy individuals. All the studied groups were carried out to measure antiGliadin antibodies IgA and IgG by ELISA test and anti-reticulin antibodies IgA and IgG by IFAT. There were significant elevation (P<0.05) in the concentration of AGA IgA and IgG antibodies compared to control group. The prevalence of AGA antibodies IgA and IgG was 8% and 9.33% respectively. There were a highly significant differences (P<0.01) between studies groups. The prevalence of antireticulin antibodies ARA IgA and IgG was 6.67% and 4.0% respectively i

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Publication Date
Thu May 04 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Morphological and Histological Study Of The Cerebrum In A Nocturnal Bird Species (Barn Owl)TytoAlba

Morphological and histoarchitecture aspects on the cerebrum of (barn owl) were made
to find outthe cerebrum size, design and the description of cerebral region components at the
light microscopic level by using Haematoxylin – Eosin and periodic acid schift (PAS)
stain methods. The result of the morphological aspects revealed that the cerebrum was large
and an obtuse triangle in shape, its surface had a slight furrow. Sagittal sections revealed
the location, arrangement and size of pallial and subpallial cerebral divisions. The result of
the microscopic examinations indicated that the large and massive hyperpallium (wulst) was
thick,hypertrophied wired, and multilaminate structure reflect their wider ste

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Publication Date
Fri Oct 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Studying the Gene Expressions of Bla OXA-51Like and Bla OXA-23Like in Acinetobacter baumannii

        Genotypic detection of some Antibiotics Resistant genes by using polymerase chain reaction (PCR). (20) Isolates of Acinetobacter baumannii that showed resistance to (Ceftaxim, Cefotaxim, Cefepim and Imipenim) were selected. The results showed that 20 isolates of A. baumannii possess the bla-OXA23 like gene, and that all isolates possess this gene with a percentage (100%). With molecular weight 605 bp. The current study showed that A. baumannii isolates carry 100% bla-OXA51like gene when studied with (20) isolates that are resistant to antibiotics (Imipenim Ceftazidime, Cifepime, Cifexime) that belong to this group of β-lactame with molecular weight 382 bp.   Gene exp

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Publication Date
Wed Dec 26 2018
Journal Name
Iraqi Journal Of Science
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Publication Date
Tue Mar 15 2022
Journal Name
Journal Of Baghdad College Of Dentistry
Effect of melatonin supplementation on the gingival health and lipid profiles in obese periodontitis patients

Background: Obesity increases the host’s susceptibility by modulating the immune and inflammatory systems in a manner that predisposes to inflammatory tissue destruction and leaves an individual at greater risk of periodontitis. Melatonin is a pineal secretory product involved in numerous actions, such as regulation of internal biological clocks and energy metabolism, and it functions as an antioxidant and anti-inflammatory agent. There exists a substantial amount of evidence supporting the beneficial effect of melatonin supplementation on obesity and its complications. Aim of the study: To investigate the effects of systemic melatonin intake on periodontal health status and lipid profiles in obese periodontitis patients. Subjects and met

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Publication Date
Wed Jan 13 2021
Journal Name
Iraqi Journal Of Science
Cost Effective Open Educational Platform to Face the Challenge of Massification in Cadi Ayyad University

This work presents the UC@MOOC project as a pedagogical innovation to face the effects of massification that are making Moroccan universities endure many constraints for the past ten years, as well as other African universities. It aims, among its objectives, to cope with the massification factor and to overcome the language difficulties encountered by students. In this project, our top priority is to reduce academic failure then we will get to the point of responding to the training' needs. Courses are scripted and posted online which did not require many resources, so their production cost is relatively low. Audiovisual digital content also helps us to save time, and go to a hybrid teaching or even flipped classrooms in some cases. The

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