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Evaluation of the Role of Serum Malondialdehyde in the Pathogenesis of Diabetic Retinopathy

Background:  The most typical consequence of diabetes mellitus is diabetic retinopathy. An important part of the etiology of diabetes and diabetic retinopathy is played by oxidative stress. Malondialdehyde is a dialdehyde that is moderately toxic and is frequently used as a marker for oxidative stress as well as lipid peroxidation.                    

Objectives: To assess the serum malondialdehyde levels in diabetic patients with and those without retinopathy and to compare these levels to controls .In additions to, investigate the relationship between serum malondialdehyde level and long glycemic control, the glycated hemoglobin (HbA1c).

Patients and Methods: This case-control study included (120) individuals from 40 to 70 years of age. They were divided into three groups: Group 1: 40 type 2diabetic patients with retinopathy, Group 2 :40 type 2 diabetic patients without retinopathy, and Group 3 40 controls .The biochemical testes included fasting blood glucose measured by Cobas c 311 systems, glycated hemoglobinHbA1c measured by Cobas c 111 systems, and serum malondialdehyde (MDA) measured by enzyme linked immunosorbent assay (ELISA).

Results: A higer mean value of (MDA) was found serum diabetic patients with and without retinopathy as compared to control (p=0.0001). As well as a significantly higher mean value of serum (MDA)  in diabetic patients with retinopathy as compared to those without (p=0.0001).A significant positive correlation was found between serum(MDA)  and HbA1C in diabetic patient with retinopathy group (r=0.931,p=0.0001) .

Conclusion: Higher serum levels of malondialdehyde is an indicator of increased lipid peroxidation that may be involved in pathogeneses of retinopathy in uncontrolled type 2 diabetic patients.

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Publication Date
Tue May 30 2023
Journal Name
Iraqi Journal Of Science
The Suitability of Fatha Clay Deposits for Clay Bricks Industry in Zurbatiya Area, Eastern Iraq

     This research aims to study the suitability of the Fatha Formation clay deposits for the brick industry in the Zurbatiya area, Wasit Government. Two sites (Al-Salam police station and Al-Taff station) were selected. The clay deposits were subjected to particle size analysis, atterberg limits, chemical and mineralogical analyses. The samples have 31.45% clay, 52.91% silt, and 15.64% sand. Chemical analyses revealed that SiO2 and CaO are the clay deposits' main components, indicating the high content of quartz and calcium carbonate. The mineralogical analysis by XRD techniques indicated that quartz, calcite, feldspar, gypsum, and dolomite are the non-clay minerals; Kaolinite, illite, palygorskite and chlorite are the mo

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Publication Date
Wed Apr 01 2020
Journal Name
Journal Of Physics: Conference Series
An Integrated Model of The Relation Between E-Service Quality and User Satisfaction in IHL
Abstract<p>Quality of e-service is one of the critical factors that decide the success or failure of organizations. It may increase competitive advantages as well as enhance the relationships with the customers. Achieving high e-service quality and user satisfaction are challenging since they depend fundamentally on user perception and expectation which can be tricky at times. To date, there is no agreement as to what service quality is, and how it should be measured, whether it is a function of statistical measures of quality including physical defects or managerial judgment, or it is a function of customer perception about the services. This paper deep-dived the quality of e-services offered b</p> ... Show More
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Publication Date
Sun Jan 01 2023
Journal Name
Ibero- American Journal Of Exercise And Sports Psychology
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Publication Date
Wed May 10 2023
Journal Name
International Journal Of Emerging Technologies In Learning
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Publication Date
Wed Jul 22 2020
Journal Name
International Journal Of Research In Pharmaceutical Sciences
Cloud point extraction method for the sensitive determination of metoclopramide hydrochloride in pharmaceutical dosage forms

In this work, a simple and very sensitive cloud point extraction (CPE) process was developed for the determination of trace amount of metoclopramide hydrochloride (MTH) in pharmaceutical dosage forms. The method is based on the extraction of the azo-dye results from the coupling reaction of diazotized MTH with p-coumaric acid (p-CA) using nonionic surfactant (Triton X114). The extracted azo-dye in the surfactant rich phase was dissolved in ethanol and detected spectrophotometrically at λmax 480 nm. The reaction was studied using both batch and CPE methods (with and without extraction) and a simple comparison between the two methods was performed. The conditions that may be affected by the extraction process and the sensitivity of m

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Publication Date
Tue Feb 28 2023
Journal Name
Iraqi Journal Of Science
Facies Architecture And Depositional Marine Systems of the Yamama Formation in Selected Wells, Southern Iraq

      The Yamama Formation is characterized by a wide geographic extension of southern Iraq. Microfacies analysis of this formation was studied in six wells distributed in six fields: Fayhaa, Sindbad, Siba, Zubair, Ratawi and West Qurna. This research aims to determine paleoenvironments by diagnosing biofacies and lithofacies. Miscellaneous marine fauna of foraminifera and calcareous algae, mainly green algae (dasycladacean.) and skeletal bioclasts from gastropods, pelecypods, bryozoans, sponge spicules, and echinoderms were found. Petrographic studies and well logs interpretations led to the identification of five main Microfacies ( Mudstone, Wackestone, Packestone, Grainestone and Rudstone and twelve submicrofacies (Foraminiferal-

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Publication Date
Mon Sep 10 2018
Journal Name
Iraqi Journal Of Physics
The influence of magnetic field and cathode dimensions on plasma characteristics in hollow cathode system

Experimental study on the effect of cylindrical hollow cathode, working pressure and magnetic field on spatial glow distribution and the characteristics of plasma produced by dc discharge in Argon gas, were investigated by image analyses for the plume within the plasma. It was found that the emission intensity appears as a periodic structure with many peaks appeared between the electrodes. Increasing the pressure leads to increase the number of intensity peaks finally converted to continuous form at high pressure, especially with applied of magnetic field, i.e. the plasma is more stable with the presence of magnetic field. The emission intensity study of plasma showed that the intensity has a maximum value at 1.07 mbar pressure and decre

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Publication Date
Tue Jan 01 2019
Journal Name
Indian Journal Of Public Health Research &amp; Development
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Publication Date
Fri Mar 29 2024
Journal Name
Iraqi Journal Of Science
Biological versus Topological Domains in Improving the Reliability of Evolutionary-Based Protein Complex Detection Algorithms

     By definition, the detection of protein complexes that form protein-protein interaction networks (PPINs) is an NP-hard problem. Evolutionary algorithms (EAs), as global search methods, are proven in the literature to be more successful than greedy methods in detecting protein complexes. However, the design of most of these EA-based approaches relies on the topological information of the proteins in the PPIN. Biological information, as a key resource for molecular profiles, on the other hand, acquired a little interest in the design of the components in these EA-based methods. The main aim of this paper is to redesign two operators in the EA based on the functional domain rather than the graph topological domain. The perturb

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Publication Date
Fri Aug 28 2020
Journal Name
Iraqi Journal Of Science
The Relationship Between Infertility and Infection with Clarithromycin Resistant Strain of Helicobacter Pylori in Iraq

The relationship between infertility and Helicobacter pylori infection was investigated; samples from thirty-five infertile patients (aged 20-49 years) were collected from Kamal Al-Samaraei hospital , Baghdad, Iraq during the period from the first of February until April 2018. These patients were compared with 10 apparently fertile individuals who served as a control. The study was carried out to detect the DNA of H.pylori in both serum and seminal fluid of male infertile patients and for the control group by Real-Time Polymerase Chain Reaction (RT-PCR) technique. The results revealed that there was a significant difference (P<0.01) in the detection of DNA of H.pylori between pa

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