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Retinal effects of Sildenafil in diabetic patients

Background
Sildenafil has been used in the treatment of erectile dysfunction (ED). However it has the disadvantage of many visual disturbances. The aim of this work is to study the effect
of sildenafil on diabetic patients which might have ocular problems due to diabetes mellitus.
Materials and Methods:
A total of 30 subjects were enrolled in the study, they were divided into two groups. The control group consisted of 10 healthy subjects but complaining of ED only and the
other (20 patients) had diabetes mellitus and ED as well. All subjects had ocular tests done before and after sildenafil intake. It was obvious that sildenafil changed visual tests from totally normal for controls, before treatent, to visual abnormality in some of the tests after treatment, such as in colour Fac Med Baghdad sense , diplopia & intra ocular pressure ( IOP ).
Results:
While certain percentage of diabetic patients had visual disturbances even before sildenafil intake. The abnormalities were in visual acuity, visual field and, in fundus
appearance. Post – treatment led to increase the percentage of patients with already existing ocular problems and extend them to include some other new ones like change in colour
sense , diplopia and increased ( IOP ).
Conclusions:
Comparing the patient group with the control , pre – treatment tests revealed that diabetic patients had already pre – existing ocular problems due to diabetes such as in the
visual acuity , visual field which were statistically not significant ( p>0.05). The only significant (p<0.05) difference was in the fundus appearance. Post – treatment results indicated more ocular damage in diabetic patients as all tests were abnormal compared to control subjects. So, although not significant but ocular complications do exist and might cause unpredictable eye damage to certain percentage of patients which should be taken into consideration.

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Publication Date
Fri Jan 13 2023
Journal Name
World Academy Of Sciences Journal
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Publication Date
Sun Apr 01 2007
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Predictive values of risk factors in management of diabetic foot

Background: Outcome of management of patients with diabetic foot is difficult to predict. Assessment of variables in history , examination and investigations were analyzed with outcome of management and whether can be assigned as prognostic factors .
Methods: prospective study of 300 patients with diabetic foot in Baghdad teaching hospital during the period from April 2000 to March 2004,certain criteria was taken in history and examination, these were investigated and treated either by conservative procedure or amputation.
Results: most common age group was 50-59 years ( 33.3%). The male to female ratio was 2:1. Conservative debridement was performed in ( 60%) of patients while amputation was employed in&nb

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Publication Date
Mon Oct 17 2022
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Relationship of the quality of life in capecitabine-treated colorectal cancer patients to sociodemographic characteristics and drug-related adverse effects

Background: Colorectal cancer (CRC) is the third most prevalent cancer worldwide with 1.80 million new
cases and 862,000 deaths in 2018. Depending on the stage, upfront surgery is the main form of treatment,
followed by adjuvant chemotherapy. Many drugs were approved by the U.S. Food and Drug Administration
for the treatment of CRC, one of which is Capecitabine. During cancer treatment, patient-reported symptoms
and quality of life parameters can provide additional information to evaluate and compare the efficacy and
toxicity of the treatments. Despite the importance of this issue, there is no published data that evaluates this
vital parameter in Iraqi patients receiving anti-cancer drugs, in general,

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Publication Date
Tue May 01 2018
Journal Name
Journal Of Physics: Conference Series
The study of Bacteriocin of Pseudomonas fluorescens and Citrus limon effects against Propionibacterium acnes and Staphylococcus epidermidis in acne patients

Research was carried out antibacterial of (Citrus limon) juice on Acnevulgaris. Samples were obtained from individuals having (Pimples) by swabbing their faces. Substances natural from plants are promising to treat disease cause Acnevulgaris, the study in vitro biological activity of the juice, as well as bacterocin cultivated and fruits was investigated on two strain bacteria (Propionibacterium acnes, Staphylococcus epidermidis). The new antimicrobial (bacteriocin and Citrus juice) is ongoing search. This study used s juice at different concentrations at (20%, 30%, 40%, 60%, 80% and 100%). The Bacteriocin produced from local P. fluorescens isolates from wound infection and majority of isolates were found to produce crude Bacteriocin were (

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Publication Date
Wed Apr 01 2009
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Possible Cytoprotective Effects of Antioxidant Drugs (Vitamin E and C) Against the Toxicity of Doxorubicin in Breast Cancer Patients

Background: Breast cancer is the culmination of a multi-step process that occurs over a period of several years or decades and as a cause of death, is a salient "free radical" disease. Aim: The present study aims on investigating the possible protective role of antioxidant drugs (vitamins E and C) to cardiac cells against the oxidative stress induced damage during doxorubicin chemotherapy in patients with breast cancer.
Patients and methods: Thirty two patients with different stages of breast carcinoma attending to Baghdad Teaching Hospital and ten healthy control subjects with age range between (29-61) years, mean (43.6±1.37) were included in this study. The patients were randomized into 3 groups, they

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Publication Date
Sun Oct 03 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Genitourinary tract infection in diabetic women: Bacteriological study

Background: The influence of glucose metabolism is seen in many infectious diseases, making  diabetic patients more vulnerable to sepsis and other serious sequelae of bacterial invasion such as UTI and vaginitis.
Patients and method: sixty two patients (women) were suffering from GUTIs consulting Al-Elwya hospital from November- 2009 to March -2010. Two samples were taken from those patients (urine samples and vaginal swabs); these samples were cultured on Blood, Chocolate, and MacConkey's agar for isolation of bacteria.
Results: The study group consists of sixty two women suffering from (GUTI), their ages range from 18-55 years. Thirty eight of them were diabetic women and twenty four of them were non

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Publication Date
Thu Sep 15 2022
Journal Name
Journal Of Baghdad College Of Dentistry
The effect of sweet and salty taste sensitivity on gin-gival health in relation to salivary serotonin among type1 diabetic patients aged 12-14 years

Background: This study was conducted among diabetic persons to assess the sweet and salty taste sensitivity with its effect on gingival health in relation to salivary serotonin levels. Materials and methods: A cross-sectional comparative study design was used. All patients with diabetes aged 12-14 years that attend the Paediatric hospital at Baghdad medical city with specific inclusion criteria were involved in the sample of the present study (patients group 50 patients) compared with non-diabetic persons matched in age and gender of the study sample (control group 70 patients) who were attending dental unit in the college of dentistry/university of Baghdad. A two-alternative forced choice question including each component presented at f

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Publication Date
Tue Jan 01 2019
Journal Name
Journal Of Global Pharma Technology
Serum levels of cross-linked n-telopeptide of Type i collagen before and after non-surgical periodontal therapy in type 2 diabetic patients with chronic periodontitis

Background: Diabetes mellitus is a major risk factor for chronic periodontitis (CP) and hyperglycemia has an important role in the enhancement of the severity of the periodontitis. It has been reported that the progression of CP causes shifting of the balance between bone formation and resorption toward osteoclastic resorption, and this will lead to the release of collagenous bone breakdown products into the local tissues and the systemic circulation. Cross-linked N-telopeptide of type I collagen (NTx) is the amino-terminal peptides of type I collagen which is released during the process of bone resorption. This study was conducted to determine the effects of nonsurgical periodontal therapy on serum level of NTx in type 2 diabetic patients

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Publication Date
Tue Apr 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Bacterial profile of urinary tract infections in Diabetic postmenopausal women

Background: Urinary tract infection (UTI) is the most common bacterial infection in women in general and in postmenopausal women in particular. Bacteriuria occurs more often in elderly functionally impaired women but in general many of it are asymptomatic.However the risk factors associated with recurrent UTI in elderly women are not widely described.Bacteuria in elderly women is associated with high mortality rates ,however many of thus bacteriuria are asymptomatic (Assel et al.,2009).The belief that diabetes ,a common metabolic disorder is associated with ahigher risk of UTI is widespread,diabetes result in several abnormalities of the host defense system that might result in a higher risk of certain infection.
Patient and Method: T

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Publication Date
Sun Nov 07 2021
Journal Name
Iraqi Journal Of Embryos And Infertility Researches
Histochemical Study of Human Placental Tissues in Gestational Diabetic Mellitus

Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder that found during gestation and is define as hyperglycemia of variable severity with onset or first recognition during gestation that does not clearly characterize any form of the preexisting diabetes (American Diabetes Association [1]). It affects approximately 16.5% of pregnancies worldwide (Plows, et al.[2]). The placenta is an organ that connects the mother and her fetus during pregnancy (Gul, et al.[3]). In the placenta, glucose can be transformed into glycogen for storage by either glycogen synthase or using glycogenin as a prime. However, the function of glycogen deposition stays a matter of debate, it may be the source of fuel for placenta itself or the storag

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