5-Fluorouracil is one of the commonly used chemotherapy drugs in anticancer therapy; unfortunately treatment with 5-FU by solely has many drawbacks  low lipophilicity, low permeability, low molecular weight, and its relatively poor plasma protein binding; also a brief half-life therefore frequent administration is required to maintain the optimal therapeutic plasma level which in addition to its poor selectivity, drug resistance and limited penetration to cancer cells; leads to increased incidence of side-effects to healthy cells/tissues and low response rates. In order to minimize these drawbacks; 5-FU was chemically  conjugated with pyrrolidine dithiocarbamate (PDTC) in a mutual prodrug moiety (S-(9H-purin-6-yl) 3-(

A new (Reversed Phase- High Performance Liquid chromatography) RP-HPLC method with Ultraviolet-Visible spectrophotometry has been optimized and validated for the simultaneous extraction and determination of antioxidants present in Iraqi calyces of Hibiscus Sabdraffia Linn. The method is based on using ultrasonic bath for extracting antioxidants. Limit of detection in μg/ml of Vitamin C, Sabdaretine, Gossypetine, Hibiscetine, Anthocyanins, Dephinidin-3-glucoside were113.8294×10-6,123.0453×10-6,70.3681×10-6,59.6730×10-6,148.1710×10-6,and125.3481×10-6 respectively. The concentration of antioxidants found in dry spacemen of calyces of Iraqi Hibiscus Sabdraffia Linn. under study: Vitamin C, Sabdaretine, Gossypetine, Hibiscetine, Anthoc

      In this paper, a modified three-step iteration algorithm for approximating a joint fixed point of non-expansive and contraction mapping is studied. Under appropriate conditions, several strong convergence theorems and Δ-convergence theorems are established in a complete CAT (0) space. a numerical example is introduced to show that this modified iteration algorithm is faster than other iteration algorithms. Finally, we prove that the modified iteration algorithm is stable. Therefore these results are extended and improved to a novel results that are stated by other researchers. Our results are also complement to many well-known theorems in the literature. This type of research can be played a vital role in computer programming

The main purpose of this work is to introduce some types of fuzzy convergence sequences of operators defined on a standard fuzzy normed space (SFN-spaces) and investigate some properties and relationships between these concepts. Firstly, the definition of weak fuzzy convergence sequence in terms of fuzzy bounded linear functional is given. Then the notions of weakly and strongly fuzzy convergence sequences of operators  are introduced and essential theorems related to these concepts are proved. In particular, if ( ) is a strongly fuzzy convergent sequence with a limit  where linear operator from complete standard fuzzy normed space  into a standard fuzzy normed space  then  belongs to the set of all fuzzy bounded linear operators

     Internet technology has revolutionized the landscape of communication technologies in the modern era. However, because the internet is open to the public, communication security cannot be guaranteed. As a result, data concealment approaches have been developed to ensure confidential information sharing. Various methods have emerged to achieve the goal of secure data communication via multimedia documents. This study proposes a method, which is both adaptable and imperceptible, for concealing a secret text in a color image. From an adaptivity perspective, image corners are detected using the Harris corner detection algorithm and utilized as anchor points for picking the optimal hiding regions of interest using Bezier curve interp

The goal of this work is demonstrating, through the gradient observation of a   of type linear ( -systems), the possibility for reducing the effect of any disturbances (pollution, radiation, infection, etc.) asymptotically, by a suitable choice of related actuators of these systems. Thus, a class of  ( -system) was developed based on finite time  ( -system). Furthermore, definitions and some properties of this concept -system and asymptotically gradient controllable system ( -controllable) were stated and studied. More precisely, asymptotically gradient efficient actuators ensuring the weak asymptotically gradient compensation system ( -system) of known or unknown disturbances are examined. Consequently, under convenient hypo

Extractive multi-document text summarization – a summarization with the aim of removing redundant information in a document collection while preserving its salient sentences – has recently enjoyed a large interest in proposing automatic models. This paper proposes an extractive multi-document text summarization model based on genetic algorithm (GA). First, the problem is modeled as a discrete optimization problem and a specific fitness function is designed to effectively cope with the proposed model. Then, a binary-encoded representation together with a heuristic mutation and a local repair operators are proposed to characterize the adopted GA. Experiments are applied to ten topics from Document Understanding Conference DUC2002 datas

     Optimization is the task of minimizing or maximizing an objective function f(x) parameterized by x. A series of effective numerical optimization methods have become popular for improving the performance and efficiency of other methods characterized by high-quality solutions and high convergence speed. In recent years, there are a lot of interest in hybrid metaheuristics, where more than one method is ideally combined into one new method that has the ability to solve many problems rapidly and efficiently. The basic concept of the proposed method is based on the addition of the acceleration part of the Gravity Search Algorithm (GSA) model in the Firefly Algorithm (FA) model and creating new individuals. Some stan

This research depends on the relationship between the reflected spectrum, the nature of each target, area and the percentage of its presence with other targets in the unity of the target area. The changes occur in Land cover have been detected for different years using satellite images based on the Modified Spectral Angle Mapper (MSAM) processing, where Landsat satellite images are utilized using two software programming (MATLAB 7.11 and ERDAS imagine 2014). The proposed supervised classification method (MSAM) using a MATLAB program with supervised classification method (Maximum likelihood Classifier) by ERDAS imagine have been used to get farthest precise results and detect environmental changes for periods. Despite using two classificatio