Breast cancer is one of the comments malignant tumors worldwide especially in Iraq; it is a leading cause of death in Iraqi women. Determination of estrogen and progesterone receptors status is helpful in selecting the patients most likely to receive benefit from endocrine therapy, and provide prognostic information on recurrence and survival since their expression is related to the degree of the tumor differentiation. From November 2012 to March 2013, 150 breast cancer patients at Al-Amal Hospital in Baghdad were attended to start treatment of disease for the first time. All patients included in this study did not receive chemotherapy. Patients were asked to bring their paraffin embedded tissue blocks to participate in estrogen, progesterone and Her-2/nue receptors estimation. Blood samples were also collected from the patients to estimate positive Her-2nue cases in serum. Age distribution in women with breast cancer showed that 44%of cases at age group (40 – 49) years. 23% of the patients had a positive family history (first and second degree). Histological types of breast carcinoma showed that 82%, 14% and 4% were ductal, lobular and mixed carcinoma respectively. The Makee classification showed that Grade I, II, and III were detected in 10%, 64% and 26% respectively. TNM staging revealed that 16% of the patients were recorded in stage I, 44% in stage II, 32% in stage III and 8% in stage IV. It was demonstrated that 72% and 70% of breast carcinomas were positive for ER and PR respectively; both markers correlated with age, family history, type, histological grade and stage of the disease. Her-2/neu showed 28% expression in Iraqi breast cancer cases. HER2/neu over-expression (>15 ng/ml) was observed in 36 out of 150 patients (24%) Her-2/neu serum level at ELISA diagnosis and in 42 out of 150 (28%) at immunohistochemistry method (IHC).There were significant (P <0.001) association between tissue HER-2/neu and serum HER-2 levels. Detection Her-2/neu in serum by ELISA technique could be used as a method for detection with high rate reached to 78% after mastectomy, also it considered as an excellent method for follow up.
Immunosuppressive cytokines are the main components of the tumor microenvironment and perform a vital function in controlling the immune response to malignant neoplasms.The objective: to study the influence of interleukin-4 (IL-4) and transforming growth factor-β3 (TGF-β3) on the development of breast tumors in women.Materials and methods. The concentration of cytokines IL-4 and TGF-β3 in blood serum was determined in 40 women with benign breast tumors, 40 women with malignant breast tumors, and 40 healthy patients without breast pathology, who were included in the control group.Breast cancer (BC) patients were divided into two groups; the first group included patients with the II stage of BC, who were considered to have a low le
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This research deals with a shrinking method concernes with the principal components similar to that one which used in the multiple regression “Least Absolute Shrinkage and Selection: LASS”. The goal here is to make an uncorrelated linear combinations from only a subset of explanatory variables that may have a multicollinearity problem instead taking the whole number say, (K) of them. This shrinkage will force some coefficients to equal zero, after making some restriction on them by some "tuning parameter" say, (t) which balances the bias and variance amount from side, and doesn't exceed the acceptable percent explained variance of these components. This had been shown by MSE criterion in the regression case and the percent explained v
... Show MoreSome of metal compounds have been synthesized of record ligand from aldehid interaction of a substance which is salicyladehyde with another material which is urea. During the analysis of the metal component, The prepared complexes were characterized by elemental analysis, IR ,UV-visible , conductivity and magnetic susceptibility measurements. this confirms the ratio[1:1] between the metal and ligand. It is found that theortical values agree with practical values All the studied complexes are suggested as an octahedral stereochemistry.
Many consumers of electric power have excesses in their electric power consumptions that exceed the permissible limit by the electrical power distribution stations, and then we proposed a validation approach that works intelligently by applying machine learning (ML) technology to teach electrical consumers how to properly consume without wasting energy expended. The validation approach is one of a large combination of intelligent processes related to energy consumption which is called the efficient energy consumption management (EECM) approaches, and it connected with the internet of things (IoT) technology to be linked to Google Firebase Cloud where a utility center used to check whether the consumption of the efficient energy is s
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The radial wavefunctions of transformed harmonic-oscillator in the local scale transformation technique are used to calculate the root-mean square proton, charge, neutron and matter radii, nuclear density distributions and elastic electron scattering charge form factors of stable (10,11B) and (unstable) exotic (8,14,17B) Boron isotopes. For 10B and 11B, the transformed harmonic-oscillator wavefunctions are applied to all subshells in no-core shell model approach using wbp interaction. For 8,14,17B, the radial wavefunctions of harmonic-oscillator and THO are used to calculate the aforementioned quantities for the core and halo parts, respectively. The calculate
... Show MoreThe emergence of staphylococci, either coagulase negative (CNS) or coagulase positive (CPS), as important human pathogens has implied that reliable methods for their identification are of large significance in understanding the diseases caused by them. The identification and characterization of staphylococci from biopsies taken from human breast tumors is reported here. Out of 32 tissue biopsies, a total of 12 suspected staphylococci grew on mannitol salt agar (MSA) medium, including 7 fermenters and 5 non-fermenter staphylococci based on traditional laboratory methods. Polymerase chain reaction (PCR) successfully identified seven isolates at the genus level as methicillin resistant St
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Background: Bone is essentially a highly vascular, living, constantly changing mineralized connective tissue. It is remarkable for its hardness, resilience and regenerative capacity, as well as its characteristic growth mechanisms. This study aimed to: 1. To evaluate the effect of bone morphogenetic protein7 (BMP7) on bone healing in artificially created intrabony defect in rabbits upper diastema, histologically. 2. To study the immunohistochemical expression of TGF-β3 and IGF-1R as bone formation markers in experimental and control groups during bone healing. Material and method: Forty male rabbits, was used in this study, 8 rabbits for each healing interval (3 days, 1,2 ,4 and 6 weeks). In each rabbit two bone holes were created on th
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