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Effects of Vitamin E and Q10 Supplementation against Doxorubicin-Induced Neurotoxicity in Rats
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Doxorubicin (DOX) is a chemotherapeutic agent; it is widely used in human malignancies. Its long-term use can cause neurobiological side-effects. Vitamin E and Coenzyme Q10may possess neuroprotective effects. This work was designed to investigate the effect of vitamin E and the coenzyme Q10(CoQ10) supplementation on neurotoxicity induced by doxorubicin(DOX) in rats. Forty nine adult rats of both sexes were used in this study; the animals were randomly enrolled into seven groups of 7 rats each. Group I: negative control (rats administered corn oil); Group II: Vitamin E at a dose of 100mg/kg/d for 3 weeks ; Group III: CoQ10 at a dose of 50 mg/kg/d for 3 weeks; Group IV: positive control (Doxorubicin 2.5 mg/kg)every other day for 2 weeks; Group V: vitamin E at a dose of 100mg/kg/d for 3 weeks administered prior to Doxorubicin at dose2.5 mg/kg every other day for 2 weeks; Group VI: CoQ10 at a dose of 50 mg/kg/d for 3 weeks administered prior to Doxorubicin at dose 2.5 mg/kg every other day for 2 weeks. Group VII: CoQ10 (50mg/kg/day), Vitamin E (100mg/kg) for 3 weeks administered prior to Doxorubicin at dose 2.5mg/kg every other day for 2 weeks. On day twenty two of the study, brain of each animal was excised and part of it to be utilized to prepare homogenate for estimation interleukin-1 beta (IL-1β),andinterleukin-10 (IL-10); the other part of brain was used for histological examination. Vitamin E and CoQ10significantly (P<0.05) decreased IL-1beta, and only combination vitamin E and CoQ10significantly (P<0.05) increased IL-10 and there was an improvement in the histopathological lesions of the brain in group V, group VI and group VII compared to group IV. In conclusion both Vitamin E and CoQ10 may have protective effect against DOX-induced neurotoxicity in rats.

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Publication Date
Thu Jun 10 2021
Journal Name
Neuroquantology
Atmospheric Emissions Effects and Mechanism
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Humanity's relationship with the environment is a delicate balance. Since the industrial revolution, the world's population has grown at an exponential rate, and this has a major environmental effect. Deforestation, pollution, and global climate change are just a few of the negative consequences of population and technological growth. Particulates, Sulphur dioxide (SO2), and nitrogen oxides (NOx) are the primary pollutants that harm our health. These contaminants may be directly emitted into the atmosphere (primary pollutants) or formed in the atmosphere from primary pollutants reacting (secondary pollutants. Tropospheric ozone is created When water reacts with volatile organic compounds (VOC) and nitrogen oxides (NOx) in the presen

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Publication Date
Sun Mar 13 2011
Journal Name
Baghdad Science Journal
Antibody response in Hamsters Immunized against experimental Leishmaniasis
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Direct agglutination test was used to evaluate the immunogenicity of three different antigens inoculated in hamsters as one , two and three doses which were: Group (1) inoculated with autoclaved killed Leishmania tropica , Group (2) inoculated with BCG vaccine alone while Group (3) inoculated with mixed antigens (autoclaved killed Leishmania "AKL"+ BCG).(4) Control animals inoculated with phosphate buffer saline. The maximum level of antibody titers were evaluated in animal inoculated with one , two or three dose of mixed antigens (320 , 640 and 1280) respectively when it compared with animals inoculated with corresponding doses of AKL antigen (80 , 160 and 320) respectively. While the minimum level of antibody titers were observed in ani

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Publication Date
Thu Dec 09 2021
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Study The Anti-Asthmatic Activity of Guggulsterone In Ovalbumin-Induced Asthma In Rat
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Asthma is a chronic in?ammatory respiratory disease associated with the changes of asthmatic airway structural that result from interact remodeling and in?ammatory processes lead to obstruction of airway. Guggulsterone (GS) is a bioactive compound and plant steroid present in  guggul gum of Commiphora wightii, which has anti-inflammatory and antioxidant activities. This study designed to investigate of anti-inflammatory activity of gugglsterone in improvement of asthma. Forty eight healthy albino male rats divided to six groups, Group I: Control group (distal water), Group II: Positive control group (distal water) with sensitization, Group III: Guggulsterone (25 mg/kg/day) with sens

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Publication Date
Tue Apr 15 2025
Journal Name
Journal Of Neonatal Surgery
Resveratrol Administration Reverses The Osteoporotic Bone In Independent-Manner Of Ahr-Esr1 Axis In Rats
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The objective  of this work was to analyze the involvement of AhR in bone metabolism using a rat model of experimental osteoporosis and to analyze the mechanisms behind its activity. Rats were assigned randomly to the subsequent groups; Control, received no treatment; ovariectomized (OVX) rats; Sham; Sham+RES received resveratrol; OVX+RES and OVX+CH received AhR’s antagonist, CH223191 (CH); and finally OVX+CHR group received both AhR antagonist along with resveratrol. Resveratrol and AhR antagonist treatment started 7 days after surgery and continued to 45 days. The serum of osteocalcin (OC) and Ca+2  was measured by ELISA and spectrophotometer, respectively. X-ray was used to estimate bone density of rats. In molecular levels,

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Publication Date
Sun Dec 31 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences( P-issn 1683 - 3597 E-issn 2521 - 3512)
Evaluation of The Genoprotective Effect of Curcumin Against Methotrexate in Bone Marrow and Spleen Cells in Mice
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Curcumin is a yellow pigment produced from the rhizomes of the Curcuma longa plant and a primary chemo preventive component of turmeric is used as a spice and food coloring ingredient. Curcumin has a large number of pharmacological activities, such as anticancer, anti-diabetic, antioxidant, anti-infectious, and anti-inflammatory properties.Investigation of the geno-protective effect of curcumin on methotrexate induces chromosomal aberrations of spleen and bone marrow cells. In this study, 32 mice were used and divided into four groups (eight mice at each group) as follows: Group1 (negative control): Dimethyl sulfoxide was given intraperitoneally to mice every day for ten days.Group2 (positive control): Mice were received a single do

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Publication Date
Thu Apr 30 2020
Journal Name
Journal Of Economics And Administrative Sciences
The impact of e-governance on achieving creative performance
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The research aims to investigate the relationship and impact of e-governance as an independent variable in achieving creative performance as a dependent variable. These variables have been studied in the Directorate of Passports Affairs, and seek to come up with a set of recommendations that help in promoting e-governance in the researched organization, and the researcher adopted the descriptive-analytical approach, included The sample (122) of the total (194) individuals distributed in several administrative levels (officers, associates, and administrative staff). By adopting the questionnaire, which included (49) paragraphs as the main tool for the collection of data and information, as well as personal interviews and field obs

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Publication Date
Wed Feb 05 2025
Journal Name
Bulgarian Journal Of Veterinary Medicine
The immunomodulatory role of clove and cinnamon extracts on Klebsiella pneumoniae infected rats.
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This study aimed to investigate the ability of clove and cinnamon extracts to make pathogenic multidrug-resistant (MDR) Klebsiella pneumoniae more sensitive to the host’s immune system and thereby interrupt the bacterial infection process in the rat model. Therefore, 60 Wistar male rats were used in this study. The phytochemical constituents of the plant extract were analysed using the gas chromatography-mass spectrometry (GC-MS) technique. Then, the capability of the plant extracts, as prophylactic and treatment, against K. pneumoniae in rats was studied by estimating the complete blood counts (CBCs) and the serum concentrations of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) before and after the treatment. The results showed that

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Anti-bacterial Properties of Melatonin against Mycobacterium Tuberculosis in Vitro
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         57 isolates of Mycobacterium tuberculosis and Mycobacterium bovis were identified; they were isolated from different clinical sources which included sputum, bronchial wash, abscess, pleural fluid, gastric fluid, eye fluid, and CSF, also urine and ear swab. This investigation was carried out on 198 patient attended National Reference Laboratory for T.B during September 2009. Also the study declared that the ratio of separation of this bacterium from male was (67.6%) and it’s higher than the ratio of separation this bacterium from females which was (32.3%). The susceptibility of Mycobacterium tuberculosis to melatonin was evaluated. Many concentrati

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Publication Date
Fri Dec 03 2021
Journal Name
Sys Rev Pharm
Evaluation Of Histological Changes In Kidney Of Male Albino Rats Treated With Silver Nanoparticles
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Publication Date
Fri Mar 20 2026
Journal Name
Baghdad Science Journal
Determination of Trace Pyridoxine Hydrochloride (Vitamin B6) in Dosage Forms and Redbull Samples Using Dispersive Liquid-Liquid Microextraction Technique Coupled with Spectrophotometry
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