Breast cancer is the most common malignancy affecting women's health, with an increasing incidence worldwide. This study aimed to measure the intracellular concentration of the hypoxia-inducible factor 1 α (HIF-1α), tumor suppression protein p53, and estradiol (E2) in tumor tissues of adult females with breast cancer and their relation to tumor grade, tumor size, and lymph node metastases (LNM). The study was conducted on 65 adult female participants with breast mass admitted to the operating theater in Al-Hussein Teaching Hospital and Al-Habboby Teaching Hospital in Nasiriyah, Iraq, from January to November 2021. Fresh breast tumor tissues were collated and homogenized for intracellular biochemical analysis using the enzyme-linked immunosorbent assay method. In total, 44 (58%) out of 65 patients, in the age range of 18-42 years and the mean±SD age of 32.55±6.40 years, had fibroadenomas, and other 21 (42%) cases, in the age range of 32-80 years and the mean±SD age of 56±14.4 years had invasive ductal carcinoma (IDC) breast cancer. Intracellular levels of HIF-1α, p53, and E2 were elevated significantly (P<0.001) in IDC cases compared to the benign group. The most malignant tumors of IDC cases were in grade III and sizes T2 and T3. The tissue concentrations of HIF-1α, P53, and E2 were significantly elevated in patients with tumor stage T3 compared to T2 and T1. A significant elevation was found in the levels of HIF-1α, p53, and E2 in the positive LNM subgroup compared to the negative LNM group. Based on the obtained results, the prognostic value of the intracellular HIF-1α is considered to be a useful prognostic factor in Iraqi women with ICD and the combination of a HIF-1α protein with the nonfunctional p53 and E2 tends to indicate the proliferation, invasiveness, and metastases of the breast tumors.
A total of 109 fish specimens belonging to six species (Barbus grypus, B. luteus, B. xanthopterus, Cyprinion macrostomum, Cyprinus carpio and Liza abu) were collected from Tigris river passing through Salah Al-Deen province during the period from September 2008 till January 2009. These fishes were infected with nine parasite species which included two sporozoans (Myxobolus mülleri and Dermocystidium percae), three ciliates (Trichodina cottidarum, T. elegini and T. murmanica) and four monogenetic trematodes (Dactylogyrus rhodeianus, D. vastator, Paradiplozoon cyprini and Microcotyle donavini). Among these parasites, two trichodinids (T. elegini and T. murmanica) were reported for the first time from fishes of Iraq. Also, B. grypus is c
... Show MoreThe present work included study of the effects of weather conditions such as solar radiation and ambient temperature on solar panels (monocrystalline 30 Watts) via proposed mathematical model, MATLAB_Simulation was used by scripts file to create a special code to solve the mathematical model , The latter is single –diode model (Five parameter) ,Where the effect of ambient temperature and solar radiation on the output of the solar panel was studied, the Newton Raphson method was used to find the output current of the solar panel and plot P-V ,I-V curves, the performance of the PV was determined at Standard Test Condition (STC) (1000W/m2)and a comparison between theoretical and experimental results were done .The best efficiency
... Show MoreDemodex species are external parasites; they are transmitted via direct contact, and when present in elevated numbers it may induce several ocular diseases. However, the symptoms are very similar to other diseases; hence, its’ role is often neglected. Therefore, an accurate diagnosis is important in order to avoid mistreatment. In this study, infestation rates in both blepharitis and chalazia were compared to an asymptomatic group, with relation to gender, age, personal hygiene, time of year, and residency. All specimens were examined immediately after collection. The aim of this study was to investigate the relationship between Demodex mites and ocular diseases. These mites were predominantly found in patie
... Show MoreA skin condition known as chronic spontaneous urticaria (CSU), which lacks an obvious triggering factor, is characterized by recurrent transient wheals, angioedema, or both for longer than six weeks. the current study was focused to study compared and diagnosis CSU by using heamatological and immunological parameters as (White blood cell count, eosinophils (EO), IL-6 and Total-IgE, in Chronic Urticaria patients were Clinically diagnosed by dermatologists in Specialized Center of Allergy in Baghdad/Al-Rusafa with age ranged between (11-60), as well as a control group included 40 with age ranged between (11-60). The results of demographic and clinical characteristics displayed the rate of female patients was higher than male which repr
... Show MoreMany of researchers have written about social responsibility and business strategy and competitive advantage, and they have given particular attention to the relationship between economic and social responsibility , but what is missing in this aspect is how the economic units that use their core competencies to advance social responsibility initiatives so that they can achieve a significant competitive advantage and create value for it ?
The current research aims to verify the view that "the economic and social objectives in the long term is not contradictory in nature but complementary objectives essential", as well as make sure that the s
... Show MoreThe present research aims to know the relation of Violence on academic Failed and School s’ Drop - out among Intermediate stage Pupils. The sample of the research reached (400) male and female pupils (failed and not failed ), and (69) male and female that Drop – out from Intermediate stage. The researcher used scale of Violence that constructed by (AL- qaysi , 2004) after she got Validity and Reliability to it . So that she used t- test for one sample, t- test for two independent sample, and Person correlation coefficient as a statistical means. The research reached to the results that indicates raising of level of Violence among the Intermediate stage pupils (failed and not failed) and the male and female that Drop – out from Inte
... Show MoreAbstract
Objectives: The study aims to: (1) Find out the relationship among participants’ age, body mass index (BMI), and Health Belief Model (HBM) related to colorectal examinations among graduate students. (2) Investigate the differences in Health Belief Model constructs between the groups of age, gender, marital status, and education level among graduate students.
Methodology: A descriptive correlational study design which conducted in the College of Fine Arts – University of Baghdad. A convenience sample of 80 graduate students were included in this study. The data were collected by using a self-reported questionnaire which consisted of two parts (I) socio-demographic characteristics (II) Colorectal Cancer Screening Beliefs
In this research, the concentration of radon gas has been calculated in the classrooms of schools in Diyala Governorate by using the nuclear track detector (CR-39), which was one of the organic solid-state nuclear detectors (SSNTDs). After calculating the radon gas concentration, the lung cancer cases were calculated. The results showed that the lowest value was found in (Alshumue) school (4.753) people. In contrast, the highest value was found in (Habhib) school (20.421). The average values of lung cancer cases in Diyala governorate were equal to (9.319) per person. The results showed that the number of lung cancer cases per year per million persons in Diyala Governorate schools was below the allowed limit from (ICRP) agency (170-230) p
... Show MoreAims: Because of the high incidence of cancer in females, we need to identify an accurate therapy to deal with the treatment of different types and stages of cancer. Histopathology acts as an important step to foresee the stage in which the cancer is present, its risk of metastasis, and the health outcomes after completion of treatment. Histopathology grading acts as an important criterion to determine the treatment pattern to be adopted, the prognosis in patients and other possible future risks. Hence conducting novel histopathologcial studies in major female cancers is necessary in determining the treatment plan to be chosen for the patient.
Study design: Retrospective Observational study
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