Preferred Language
Articles
/
chilcJQBVTCNdQwCqBcW
Enhancing the therapeutic potential of curcumin: a novel nanoformulation for targeted anticancer therapy to colorectal cancer with reduced miR20a and miR21 expression
...Show More Authors
Abstract<p>Curcumin (Cur) possesses remarkable pharmacological properties, including cardioprotective, neuroprotective, antimicrobial, and anticancer activities. However, the utilization of Cur in pharmaceuticals faces constraints owing to its inadequate water solubility and limited bioavailability. To overcome these hurdles, there has been notable focus on exploring innovative formulations, with nanobiotechnology emerging as a promising avenue to enhance the therapeutic effectiveness of these complex compounds. We report a novel safe, effective method for improving the incorporation of anticancer curcumin to induce apoptosis by reducing the expression levels of miR20a and miR21. The established method features three aspects that, to our knowledge, have not been formally verified: (1) use of a novel formula to incorporate curcumin, (2) use of all biocompatible biodegradable materials to produce this formula without leaving harmful residues, and (3) an incorporation process at temperatures of approximately 50 °C. The formula was prepared from lecithin (LE), and chitosan (CH) with an eco-friendly emulsifying agent and olive oil as the curcumin solvent. The formula was converted to nanoscale through ultrasonication and probe sonication at a frequency of 20 kHz. Transmission electron microscopy showed that the nano formula was spherical in shape with sizes ranging between 49.7 nm in diameter and negative zeta potentials ranging from 28 to 34 mV. Primers miR20a and miR21 were designed for molecular studies. Nearly complete curcumin with an encapsulation efficiency of 91.1% was established using a straight-line equation. The nano formula incorporated with curcumin was used to prepare formulations that exhibited anticancer activities. The apoptosis pathway in cancer cells was activated by the minimum inhibitory concentration of the nano formula. These findings suggest the potential of this nanoformulation as an effective and selective cancer treatment that does not affect the normal cells.</p>
Scopus Clarivate Crossref
View Publication
Publication Date
Thu Jul 01 1999
Journal Name
Bulletin Of The Iraq Natural History Museum (p-issn: 1017-8678 , E-issn: 2311-9799)
Hydrophilidae of Iraq (insect , Coleopterws)
...Show More Authors

This work reports thirty three Iraqi species and one subspecies of Hydrophilidae, distributed in eleven genera under four subfamilies. Of them two species namely Laccobius gracilis Motsch and Laccobius syriacus Guilleb. Are new records for Iraq. The locality data were mentioned for each species.

View Publication Preview PDF
Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
phylogentic study of cephalopharyngeal selerites
...Show More Authors

drosophila larvare of diffrent speces were subjected to this in order study the structure of cephalopharyngeal armature and mouth more hooks dentition the lines number among

View Publication Preview PDF
Publication Date
Tue Jul 31 2018
Journal Name
العلوم السياسية
Legal regulation of electronic contracting
...Show More Authors

The use of legislation related to electronic contracting, through the adoption of the method of enactment of legislation and legislative intervention, and to be careful and cautious in the issuance of legislative texts that do not adversely affect the business activity, which is taking its steps for the first time on the path of electronic commerce in this new world by the new knowledge of the subject theoretically and practically , With the necessary assistance of legal expertise so that legislation does not constitute barriers and obstacles to the development of electronic commerce.

View Publication
Publication Date
Sun Oct 01 2023
Journal Name
Baghdad Science Journal
Biological peculiarities of Leucozonella retteri
...Show More Authors

The aim of the research is to study the biology, life cycles, distribution and structure of the reproductive organ of Leucozonella retteri in natural conditions. Zoological and malacological methods are used in the work. The collection of the material was carried out according to A.A. Shileiko method. According to the results of the conducted studies, the differences between Leucozonella retteri and other species in the structure of the reproductive organ were manifested in the following. The lower part of the sperm is straight, the ovary is slightly curved. The paw pad is 8, located in 4x2 positions. The stylophore is large spherical. The vagina is cylindrical, its length is 5-6 times greater than the width. The penis is large and conve

... Show More
View Publication Preview PDF
Scopus (1)
Scopus Crossref
Publication Date
Tue Jun 01 2010
Journal Name
Al-khwarizmi Engineering Journal
Kinetic Study of Esterification Reaction
...Show More Authors

The Esterification kinetics of acetic acid with ethanol in the presence of sulfuric acid as a homogenous catalyst was studied with isothermal batch experiments at 50-60°C and at a different molar ratio of ethanol to acetic acid [EtOH/Ac]. Investigation of kinetics of the reaction indicated that the low of [EtOH/Ac] molar ratio is favored for esterification reaction, this is due to the reaction is catalyzed by acid. The maximum conversion, approximately 80% was obtained at 60°C for molar ratio of 10 EtOH/Ac. It was found that increasing temperature of the reaction, increases the rate constant and conversion at a certain mole ratio, that is due to the esterification is exothermic. Activity coefficients were calculated using UNIFAC progra

... Show More
View Publication Preview PDF
Publication Date
Fri Jan 01 2010
Journal Name
Journal Of Collage Of Education
Some Generalizations of Continuity Functions
...Show More Authors

In this paper we define and study new generalizations of continuous functions namely, -weakly (resp., w-closure, w-strongly) continuous and the main properties are studies: (a) If f : X®Y is w-weakly (resp., w-closure, w-strongly) continuous, then for any AÌX and any BÌY the restrictions fïA : A®Y and fB : f -1(B)®B are w-weakly (resp., w-closure, w-strongly) continuous. (b) Comparison between deferent forms of generalizations of continuous functions. (c) Relationship between compositions of deferent forms of generalizations of continuous functions. Moreover, we expanded the above generalizations and namely almost w-weakly (resp., w-closure, w-strongly) continuous functions and we state and prove several results concerning it.

Preview PDF
Publication Date
Sat Jan 01 2022
Journal Name
Journal Of Kufa Legal And Political Science
Civil Rights Protection of Minorities
...Show More Authors

The protection of the rights of minorities is primarily an internal issue that depends on the nature of the political system of the state, and it is one of the internal means to reassure minorities and ensure their enjoyment of those rights. It can be a safety valve against the problems that these minorities may raise. that live in our society, but rather work on developing a legal system that can serve as a role model to protect our minorities, which contributed to drawing a picture that reflected the diversity of our society

Publication Date
Mon Jan 01 2024
Journal Name
Pakistan Journal Of Life And Social Sciences (pjlss)
Mental Durability of Postgraduate Students
...Show More Authors

View Publication
Scopus Crossref
Publication Date
Wed Jun 01 2022
Journal Name
Political Sciences Journal
Radical democracy of Axel Honneth
...Show More Authors

In contemporary discourses the debate of most Western thinkers is about the efforts to clarify the normative foundations of democracy. And then, some political thinkers have adopted other models differ in terms of standards for traditional liberal democracy. Be the common goal of democracy will give the formation of a greater role than usual in political liberalism rather than limiting the participatory activity of citizens on the function to give permanent legitimacy to the exercise of state authority. The activity is to be permanently enshrined in the democratic public sphere and the issue must be understood as the source of all political decisions.

 

View Publication Preview PDF
Crossref
Publication Date
Tue Nov 20 2018
Journal Name
Infection And Immunity
Acknowledgment of ad hoc reviewers
...Show More Authors

View Publication