Drug solubility and dissolution remain a significant challenge in pharmaceutical formulations. This study aimed to formulate and evaluate repanglinide (RPG) nanosuspension-based buccal fast-dissolving films (BDFs) for dissolution enhancement. RPG nanosuspension was prepared by the antisolvent-precipitation method using multiple hydrophilic polymers, including soluplus®, polyvinyl alcohol, polyvinyl pyrrolidine, poloxamers, and hydroxyl propyl methyl cellulose. The nanosuspension was then directly loaded into BDFs using the solvent casting technique. Twelve formulas were prepared with a particle size range of 81.6-1389 nm and PDI 0.002-1 for the different polymers. Nanosuspensions prepared with soluplus showed a favored mean particle size o

Chemotherapy is one of the most efficient methods for treating cancer patients. Chemotherapy aims to eliminate cancer cells as thoroughly as possible. Delivering medications to patients’ bodies through various methods, either oral or intravenous is part of the chemotherapy process. Different cell-kill hypotheses take into account the interactions of the expansion of the tumor volume, external drugs, and the rate of their eradication. For the control of drug usage and tumor volume, a model based smooth super-twisting control (MBSSTC) is proposed in this paper. Firstly, three nonlinear cell-kill mathematical models are considered in this work, including the log-kill, Norton-Simon, and hypotheses subject to parametric uncertainties and exo

      As a new technology, blockchain provides the necessary capabilities to assure data integrity and data security through encryption. Mostly, all existing algorithms that provide security rely on the process of discovering a suitable key. Hence, key generation is considered the core of powerful encryption. This paper uses Zernike moment and Mersenne prime numbers to generate strong prime numbers by extracting the features from biometrics (speech). This proposed system sends these unique and strong prime numbers to the RSA algorithm to generate the keys. These keys represent a public address and a private key in a cryptocurrency wallet that is used to encrypt transactions. The benefit of this work is that it provides a high degree

Robots have become an essential part of modern industries in welding departments to increase the accuracy and rate of production. The intelligent detection of welding line edges to start the weld in a proper position is very important. This work introduces a new approach using image processing to detect welding lines by tracking the edges of plates according to the required speed by three degrees of a freedom robotic arm. The two different algorithms achieved in the developed approach are the edge detection and top-hat transformation. An adaptive neuro-fuzzy inference system ANFIS was used to choose the best forward and inverse kinematics of the robot. MIG welding at the end-effector was applied as a tool in this system, and the wel

The use of online social network (OSN) has become essential to humans' lives whether for entertainment, business or shopping. This increasing use of OSN motivates designing and implementing special systems that use OSN users' data to provide better user experience using machine learning and data mining algorithms and techniques. One system that is used extensively for this purpose is friend recommendation system (FRS) in which it recommends users to other users in professional or entertaining online social networks.

For this purpose, this study proposes a novel friend recommendation system, namely Hybrid Friend Recommendation (FR) model. The Hybrid model applies dual-stage methodology on unlabeled data of 1241 users collected fro

The Internet of Things (IoT) is an information network that connects gadgets and sensors to allow new autonomous tasks. The Industrial Internet of Things (IIoT) refers to the integration of IoT with industrial applications. Some vital infrastructures, such as water delivery networks, use IIoT. The scattered topology of IIoT and resource limits of edge computing provide new difficulties to traditional data storage, transport, and security protection with the rapid expansion of the IIoT. In this paper, a recovery mechanism to recover the edge network failure is proposed by considering repair cost and computational demands. The NP-hard problem was divided into interdependent major and minor problems that could be solved in polynomial t

Orthogonal polynomials and their moments serve as pivotal elements across various fields. Discrete Krawtchouk polynomials (DKraPs) are considered a versatile family of orthogonal polynomials and are widely used in different fields such as probability theory, signal processing, digital communications, and image processing. Various recurrence algorithms have been proposed so far to address the challenge of numerical instability for large values of orders and signal sizes. The computation of DKraP coefficients was typically computed using sequential algorithms, which are computationally extensive for large order values and polynomial sizes. To this end, this paper introduces a computationally efficient solution that utilizes the parall

       In recent years, encryption technology has been developed rapidly and many image encryption methods have been put forward. The chaos-based image encryption technique is a modern encryption system for images. To encrypt images, it uses random sequence chaos, which is an efficient way to solve the intractable problem of simple and highly protected image encryption. There are, however, some shortcomings in the technique of chaos-based image encryption, such limited accuracy issue. The approach focused on the chaotic system in this paper is to construct a dynamic IP permutation and S-Box substitution by following steps. First of all, use of a new IP table for more diffusion of al