Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
تعد الضريبة مصدراً مهماً لتحقيق الاهداف الاقتصادية والاجتماعية والسياسية للدولة ولذلك فان مشكلة التهرب الضريبي تعد اهم المشاكل التي ينبغي معالجتها من خلال معرفة اسبابها . ان وجود مشكلة التهرب الضريبي في العراق يرتبط بمجموعة من الاسباب والدوافع الكامنة وراء ظهور هذه المشكلة والتي لا نستطيع ان نلقي بتباعها على تخلف النظام الضريبي من حيث تشخيص الاختلالات في الادارة الضريبية تارة بل يجب ابراز عيوب التشريع الض
... Show MoreThe urban Gentrification is an inclusive global phenomenon to restructure the cities on the overall levels, the research to propose a specific study about the concept of urban Gentrification in the cities and showcasing its, specifications, and results, and how to deal with the variables that occur on cities through improvements as part of urban renewal projects, then the general axis of the research is shrinked, choosing the urban centers as the most important areas that deal with the urban Gentrification process due to its direct connection with indivisuals and social changes, and to process the specific axis of the research theses and studies will be showcased that discuss the topic in different research directions, and emerged
... Show MoreThe wall of Eastern side considers one of the important prominence architect sign of Baghdad city through Abbasid era , it is surrounded by many shops, houses , the work had started in the period of caliph( Al-Mustathher Billah )
يعد الاهتمام بأصحاب الهمم مطلب ديني لجميع الأديان ومطلب اجتماعي لانهم جزء أساسي من المجتمع ينبغي ان يحصلوا على فرصتهم وحقوقهم كباقي افراد المجتمع، فضلا عن كونه مطلب تربوي، إذ يعاني التلاميذ أصحاب الهمم من مشكلات عديدة وذلك لا سباب ترجع لخصائصهم وصفاتهم الخاصة التي ولدوا بها أو اكتسبوها بعد الولادة لسبب من الأسباب، لذا نجدهم يعانون من صعوبات في اكتساب المهارات والخبرات الحياتية بصورة عامة والتعليمية بصورة
... Show Moreاشكالية بناء ثقافة مشاركة في الوطن العربي
Los lingüistas no árabes suelen quedar perplejos a la hora de interpretar el fenómeno de Al-ḍdad, −normalmente traducido en español como palabras autoantónimas (1)− en la lengua árabe, en el que los arabistas, y entre ellos los españoles, han quedado sombrosos ante este fenómeno. El jefe del tribunal de la defensa de mi tesis me pidió que le explicara este fenómeno según mi teoría “El esquema básico de la referencia”; pues me dijo que no podía imaginar que una palabra tuviera dos significados opuestos, y en ese momento le expliqué la palabra albayn البين que significa la separación, o la relación o el enlace que comentar
... Show MoreIn a controversy between the intellectuals and doctors of Legal and Islamic
scholars, about the legality of medication organs and human parts, comes this
study, in order to reveal the controls of Islamic in that issue above, and to show the
effectiveness of Islam and its role, and the extent needed in the treatment of
problems intractable, and the resolution of the controversy in the case above, in
order to preserve the human dignity and the right integration of physical, and
prevents from Aptmalh, and included in the financial contracts, and to achieve that
goal, presented the study to the issue of the rule of medication and look to Islam to
him, and the rule of therapeutics in human organs, and the views of Almj