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bijps-2030
Cytotoxic Evaluation of Doxorubicin Combination with Baicalein and Resveratrol Against Hct116 and Hepg2 Cancer Cell Lines (Conference Paper) #
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Combination of natural poly-phenolic compounds with chemotherapeutic agents is recently being a novel strategy in cancer therapy researches owing to their potential antioxidant and anti-inflammatory properties that modulate several intracellular signaling pathways.

Resveratrol and Baicalein are well known poly-phenolic compounds that belong to stilbene and flavone subclasses, respectively.

This study aims to investigate the possible enhancement effect of resveratrol and Baicalein when combined with doxorubicin using a different combination ratio and applied on two cancer cell lines: HCT116 (colorectal cancer cells) and HepG2 (hepatocellular cancer cells). It also investigates the possibility of such natural compounds to provide a protection effect on cardiocytes (H9C2) when resveratrol and Baicalein treatment followed by doxorubicin is used. 

The two cancer cell lines were treated with different combination groups, including the combination between doxorubicin and Baicalein or resveratrol and the combination between the three compounds using a different combination ratio for both treatment groups (i.e., two drugs or three drugs combination). Treatment applied on cells, using cell density of 7000 cells /well and incubation time was 48 hrs. MTT test was performed to assay the cell viability.

The results obtained showed that the cytotoxicity of doxorubicin in the two cancer cell lines has increased when combined with Baicalein and resveratrol. Doxorubicin IC50 decreased from 4.99 µg/ml to 0.3657 µg/ml and from 7.3 µg/ml to 0.676 µg/ml on HCT116 and HepG2 cells, respectively, using constant combination ratio (1:1:1).

The combination of doxorubicin, Baicalein, and resveratrol has resulted in a less cardiotoxic effect compared to treatment with doxorubicin alone. This decrease was obviously seen when the three compounds were combined using a low concentration range and with a constant combination ratio.

Conclusion: combinations of Baicalein and resveratrol with doxorubicin chemotherapeutic drug In Vitro had enhanced the cytotoxic activity of such a chemotherapeutic drug, while simultaneously eliminating its cardio-toxicity side effect.

 

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Publication Date
Sat Sep 01 2007
Journal Name
Journal Of Economics And Administrative Sciences
Operations Strategy and Technological Change
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This research aims to deal with contemporary knowledge  methodology to correlate between operations strategy and technological change or modernization in productive paths for industrial organizations depend on practical indicators for competitive  priorities that is objectives of operations performance.

The research is based on main hypothesis, concentrates on determination of technological change which is decided by the level of technology deterioration in current operations path compared with the competitors leaders-technology leaders.

We apply these concepts on hypothetical case to two similar companies in their production nature and te

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Publication Date
Tue Jan 01 2013
Journal Name
Baghdad: Al-farahihdi Publishing House
Studies in Translation and Culture
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Publication Date
Fri Mar 02 2018
Journal Name
Vitiligo
Therapeutic Needling and Needling Micrografting
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Publication Date
Fri Feb 01 2019
Journal Name
Journal Of The College Of Education For Women
ABU OBAYDA and Syntax Studies
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ABU OBAYDA and Syntax Studies

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Publication Date
Thu Jun 10 2021
Journal Name
Neuroquantology
Atmospheric Emissions Effects and Mechanism
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Humanity's relationship with the environment is a delicate balance. Since the industrial revolution, the world's population has grown at an exponential rate, and this has a major environmental effect. Deforestation, pollution, and global climate change are just a few of the negative consequences of population and technological growth. Particulates, Sulphur dioxide (SO2), and nitrogen oxides (NOx) are the primary pollutants that harm our health. These contaminants may be directly emitted into the atmosphere (primary pollutants) or formed in the atmosphere from primary pollutants reacting (secondary pollutants. Tropospheric ozone is created When water reacts with volatile organic compounds (VOC) and nitrogen oxides (NOx) in the presen

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Publication Date
Mon Jan 01 2001
Journal Name
Iraqi Journal Of Science
C.F Modules and C.P Modules
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Let R be a commutative ring with identity. R is said to be P.P ring if every principle ideal of R is projective. Endo proved that R is P.P ring if and only if Rp is an integral domain for each prime ideal P of R and the total quotient ring Rs of R is regular. Also he proved that R is a semi-hereditary ring if and only if Rp is a valuation domain for each prime ideal P of R and the total quotient Rs of R is regular. , and we study some of properties of these modules. In this paper we study analogue of these results in C.F, C.P, F.G.F, F.G.P R-modules.

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Publication Date
Thu May 31 2018
Journal Name
الاستاذ للعلوم الانسانية والاجتماعية
Tolerance between Christianity and Islam
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The Christian religion came in love and co-existence with all human beings, united in the minds of its people, including the great creation to form a strong unit of high ethics that contributes to the unity among the members of society and coexistence in security, peace and love of harmony.

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Publication Date
Mon Aug 01 2022
Journal Name
Baghdad Science Journal
Semihollow-Lifting Modules and Projectivity
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Throughout this paper, T is a ring with identity and F is a unitary left module over T. This paper study the relation between semihollow-lifting modules and semiprojective covers. proposition 5 shows that If T is semihollow-lifting, then every semilocal T-module has semiprojective cover. Also, give a condition under which a quotient of a semihollow-lifting module having a semiprojective cover. proposition 2 shows that if K is a projective module. K is semihollow-lifting if and only if For every submodule A of K with K/( A) is hollow, then K/( A) has a semiprojective cover.

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Publication Date
Sat May 16 2009
Journal Name
Journal Of Planner And Development
Investment policy and regional development
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The unbalanced distribution of investments in the economic fields of the 1950s had a negative impact on the overall economic life of the country in that period and subsequent periods. Since the 1960s, the planning agencies have tried to reduce the negative impact of imbalance in regional development and the emergence of disparities in development between the regions of the country and to identify disparities in levels of spatial development. At the planning level, there have been many studies and mathematical and statistical models to analyze variance and clarify its dimensions and to measure the degree of developmental disparity between Regions and means of narrowing this problem and the development of policies and strategies for develo

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Publication Date
Thu Jan 31 2019
Journal Name
Journal Of The College Of Education For Women
Reading Comprehension: Theory and Application
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This study aims at discussing the theoretical and applicable parts of the reading comprehension to help the teachers of Arabic. This study shows that the students have a general weakness in reading comprehension. The researcher handles issues related to reading comprehension and to practicing exercises of the training strategies such as: dialogue, discussion, discussion questions, continuous training, group works. Such skills will be used to analyze a poem to see the level of the students’ reading comprehension and to develop the students’ skills. The study answers two questions:
1- What is the reading comprehension from a theoretical perspective?
2- How can we develop the skills of the reading comprehension from the practical

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