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Effects of Vitamin D3 on Methotrexate- Induced Jejunum Damage in Rats
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Both methotrexate and vitamin D3 are used in combination for the treatment of various diseases. The aim of this study is to highlight the effect of vitamin D3 on methotrexate-induced jejunum damage using biochemical and   histopathological  studies. Seven groups of both sexes of rats were selected and treated as follows: (Group I and Group II) : control 1,control 2 (I.P normal saline) daily for 14 and 21 days respectively ; (Group III and Group IV) :vitamin D3 groups (500 IU/rat/day) orally for 14 and 21 days, respectively;(Group V): once daily dose of methotrexate 20mg/kg, I.P injected for 4 days;(Group VI):vitamin D3 (500 IU/rat/day) once daily for 14 days and methotrexate (20 mg/kg I.P) injected only at day 10;.(Group VII) vitamin D3 (500 IU/rat/day) orally for 21 days and methotrexate (20 mg/kg I.P) injected only at day 17; then the jejunum was removed and used for measuring malondialdehyde (MDA) content, total antioxidant capacity (TAOC) level; in addition histopathological study of jejunum tissue. Administration of vitamin D3 for 21 days and a single dose of methotrexate at day 17 resulted in non-significant difference (P>0.05) in MDA; while significant reduction (P<0.05) in the TAOC level in jejunum tissue; furthermore , sever villi damage ,crypts abscess, epithelial atrophy , mixed inflammatory cells infiltrate and goblet cells depletion were observed in comparison with methotrexate group. So the study demonstrates that vitamin D3 plays a synergistic role with methotrexate therefore the combined use of vitamin D3 and methotrexate may be used as a strategy to overcome dose limitations and side effects when use for the treatment of cancer, rheumatoid arthritis and psoriasis.

Key words: Jejunum damage, Methotrexate, Oxidative stress, Rats, Vitamin D3.

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Publication Date
Tue Mar 01 2011
Journal Name
Journal Of Economics And Administrative Sciences
Notes on Weibull Distribution
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Weibull Distribution is one of most important distribution and it is mainly used in reliability and in distribution of life time. The study handled two parameter and three-parameter Weibull Distribution in addition to five –parameter Bi-Weibull distribution. The latter being very new and was not mentioned before in many of the previous references. This distribution depends on both the two parameter and the three –parameter Weibull distributions by using the scale parameter (α) and the shape parameter (b) in the first and adding the location parameter (g)to the second and then joining them together to produce a distribution with five parameters.

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Publication Date
Mon Mar 01 2021
Journal Name
Journal Of Physics: Conference Series
On Small Semiprime Submodules
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Abstract<p>Let R be a commutative ring with identity, and M be unital (left) R-module. In this paper we introduce and study the concept of small semiprime submodules as a generalization of semiprime submodules. We investigate some basis properties of small semiprime submodules and give some characterizations of them, especially for (finitely generated faithful) multiplication modules.</p>
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Publication Date
Wed Oct 01 2014
Journal Name
Journal Of Economics And Administrative Sciences
ON DISCRETE WEIBULL DISTRIBUTION
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Most of the Weibull models studied in the literature were appropriate for modelling a continuous random variable which assumes the variable takes on real values over the interval [0,∞]. One of the new studies in statistics is when the variables take on discrete values. The idea was first introduced by Nakagawa and Osaki, as they introduced discrete Weibull distribution with two shape parameters q and β where      0 < q < 1 and b > 0. Weibull models for modelling discrete random variables assume only non-negative integer values. Such models are useful for modelling for example; the number of cycles to failure when components are subjected to cyclical loading. Discrete Weibull models can be obta

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Publication Date
Sun Sep 04 2011
Journal Name
Baghdad Science Journal
On Primary Multipliction Modules
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Let R be a commutative ring with identity and M be a unitary R- module. We shall say that M is a primary multiplication module if every primary submodule of M is a multiplication submodule of M. Some of the properties of this concept will be investigated. The main results of this paper are, for modules M and N, we have M N and HomR (M, N) are primary multiplications R-modules under certain assumptions.

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Publication Date
Mon Apr 04 2016
Journal Name
Journal Of Advances In Mathematics
ON CJ-TOPLOGICAL SPACES
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Publication Date
Fri May 01 2020
Journal Name
Journal Of Physics: Conference Series
On µ-Semiregular Module
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Abstract<p>Let R be an associative ring with identity and let M be right R-module M is called μ-semi hollow module if every finitely generated submodule of M is μ-small submodule of M The purpose of this paper is to give some properties of μ-semi hollow module. Also, we gives conditions under, which the direct sum of μ-semi hollow modules is μ-semi hollow. An R-module is said has a projective μ-cover if there exists an epimorphism <italic>f</italic>:P→M Where P is a projective R-module and ker (<italic>f</italic>)<sub>≪</sub> P.And study some properties of Projective μ-cover of M. Were studied Moreover, An module M is μ-semiregular module if every cyclic</p> ... Show More
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Publication Date
Sun Mar 02 2008
Journal Name
Baghdad Science Journal
On New Algebraic Systems
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The purpose of this paper is to give some results theorems , propositions and corollaries concerning new algebraic systems flower , garden and farm with accustomed algebraic systems groupoid , group and ring.

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Publication Date
Fri May 01 2020
Journal Name
Journal Of Physics: Conference Series
On J–Lifting Modules
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Abstract<p>Let R be a ring with identity and M is a unitary left R–module. M is called J–lifting module if for every submodule N of M, there exists a submodule K of N such that <inline-formula> <tex-math><?CDATA ${\rm{M}} = {\rm{K}} \oplus \mathop {\rm{K}}\limits^\prime,\>\mathop {\rm{K}}\limits^\prime \subseteq {\rm{M}}$?></tex-math> <math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="block" overflow="scroll"> <mrow> <mi mathvariant="normal">M</mi> <mo>=</mo> <mi mathvariant="normal">K</mi></mrow></math></inline-formula></p> ... Show More
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Publication Date
Wed Mar 30 2022
Journal Name
Iraqi Journal Of Science
On Annihilator-Extending Modules
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    Throughout this work we introduce the notion of Annihilator-closed submodules, and we give some basic properties of this concept. We also introduce a generalization for the Extending modules, namely Annihilator-extending modules. Some fundamental properties are presented as well as  we discuss the relation between this concept and some other related concepts.

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Publication Date
Fri Sep 30 2022
Journal Name
College Of Islamic Sciences
Shariah ruling on advice
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Abstract

Research title: The legal ruling of advice.

This research deals with the topic of advice, as the research included the following:

Preamble: I explained in it the meaning of advice in the Qur’an and Sunnah, and that what is meant by it is a good performance of the duty, then explaining its importance, importing it, and the difference between advice and what is similar to it, from enjoining good, denial, reproach and reprimand, backbiting and the will.

The first topic: It dealt with the ruling on advice, whether it is recommended or disliked, or forbidden, because what is meant by it is to give advice to others may be an obligation in kind, or it may be desirable or dislike

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