Coumarins have been recognized as anticancer competitors. HDACis are one of the interesting issues in the field of antitumor research. In order to achieve an increased anticancer efficacy, a series of hybrid compounds bearing coumarin scaffolds have been designed and synthesized as novel HDACis, In this review we present a series of novel HDAC inhibitors comprising coumarin as a core e of cap group of HDAC inhibitors that have been designed, synthesized and assessed for their enzyme inhibitory activity as well as antiproliferative activity. Most of them exhibited potent HDAC inhibitory activity and significant cytotoxicity
The basic solution to overcome difficult issues related to huge size of digital images is to recruited image compression techniques to reduce images size for efficient storage and fast transmission. In this paper, a new scheme of pixel base technique is proposed for grayscale image compression that implicitly utilize hybrid techniques of spatial modelling base technique of minimum residual along with transformed technique of Discrete Wavelet Transform (DWT) that also impels mixed between lossless and lossy techniques to ensure highly performance in terms of compression ratio and quality. The proposed technique has been applied on a set of standard test images and the results obtained are significantly encourage compared with Joint P
... Show MoreA frequently used approach for denoising is the shrinkage of coefficients of the noisy signal representation in a transform domain. This paper proposes an algorithm based on hybrid transform (stationary wavelet transform proceeding by slantlet transform); The slantlet transform is applied to the approximation subband of the stationary wavelet transform. BlockShrink thresholding technique is applied to the hybrid transform coefficients. This technique can decide the optimal block size and thresholding for every wavelet subband by risk estimate (SURE). The proposed algorithm was executed by using MATLAB R2010aminimizing Stein’s unbiased with natural images contaminated by white Gaussian noise. Numerical results show that our algorithm co
... Show MoreIntrusion-detection systems (IDSs) aim at detecting attacks against computer systems and networks or, in general, against information systems. Most of the diseases in human body are discovered through Deoxyribonucleic Acid (DNA) investigations. In this paper, the DNA sequence is utilized for intrusion detection by proposing an approach to detect attacks in network. The proposed approach is a misuse intrusion detection that consists of three stages. First, a DNA sequence for a network traffic taken from Knowledge Discovery and Data mining (KDD Cup 99) is generated. Then, Teiresias algorithm, which is used to detect sequences in human DNA and assist researchers in decoding the human genome, is used to discover the Shortest Tandem Repeat (S
... Show MoreImportance of Arabic language stemming algorithm is not less than that of other languages stemming in Information Retrieval (IR) field. Lots of algorithms for finding the Arabic root are available and they are mainly categorized under two approaches which are light (stem)-based approach and root-based approach. The latter approach is somehow better than the first approach. A new root-based stemmer is proposed and its performance is compared with Khoja stemmer which is the most efficient root-based stemmers. The accuracy ratio of the proposed stemmer is (99.7) with a difference (1.9) with Khoja stemmer.
Most includeding techniques of digital watermark even now working through the direct inclusion in the pixel without taking into account the level of compression (attack) that can go wrong, which makes digital watermark can be discarded easily. In this research, a method was proposed to overcome this problem, which is based on DCT (after image partitioned into non overlapped blocks with size 8×8 pixel), accompanied by a quantization method. The watermark (digital image) is embedded in DCT frequency domain seeking the blocks have highest standard deviation (the checking is only on the AC coefficients) within a predetermined threshold value, then the covered image will compressed (attacked) varying degrees of compression. The suggested met
... Show MoreAdvances in digital technology and the World Wide Web has led to the increase of digital documents that are used for various purposes such as publishing and digital library. This phenomenon raises awareness for the requirement of effective techniques that can help during the search and retrieval of text. One of the most needed tasks is clustering, which categorizes documents automatically into meaningful groups. Clustering is an important task in data mining and machine learning. The accuracy of clustering depends tightly on the selection of the text representation method. Traditional methods of text representation model documents as bags of words using term-frequency index document frequency (TFIDF). This method ignores the relationship an
... Show MoreBackground: image processing of medical images is major method to increase reliability of cancer diagnosis.
Methods: The proposed system proceeded into two stages: First, enhancement stage which was performed using of median filter to reduce the noise and artifacts that present in a CT image of a human lung with a cancer, Second: implementation of k-means clustering algorithm.
Results: the result image of k-means algorithm compared with the image resulted from implementation of fuzzy c-means (FCM) algorithm.
Conclusion: We found that the time required for k-means algorithm implementation is less than that of FCM algorithm.MATLAB package (version 7.3) was used in writing the programming code of our w
Algorithms for Arabic stemming available in two main types which are root-based approach and stem-based approach. Both types have problems which have been solved in the proposed stemmer which combined rules of both main types and based on Arabic patterns (Tafealat1) to find the added letters. The proposed stemmer achieved root exploration ratio (99.08) and fault ratio (0.9).
The investigation of signature validation is crucial to the field of personal authenticity. The biometrics-based system has been developed to support some information security features.Aperson’s signature, an essential biometric trait of a human being, can be used to verify their identification. In this study, a mechanism for automatically verifying signatures has been suggested. The offline properties of handwritten signatures are highlighted in this study which aims to verify the authenticity of handwritten signatures whether they are real or forged using computer-based machine learning techniques. The main goal of developing such systems is to verify people through the validity of their signatures. In this research, images of a group o
... Show MoreIn the last decade, 3D models gained interest in many applications, such as games, the medical field, and manufacture. It is necessary to protect these models from unauthorized copying, distribution, and editing. Digital watermarking is the best way to solve this problem. This paper introduces a robust watermarking method by embedding the watermark in the low-frequency domain, then selecting the coarsest level for embedding the watermark based on the strength factor. The invisibility of the watermark for the proposed algorithm is tested by using different measurements, such as HD and PSNR. The robustness was tested by using different types of attacks; the correlation coefficient was applied for the evaluati
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