A group of amino derivatives [4-aminobenzenesulfonamide,4-amino-N¹ methylbenzenesulfonamide, or N¹-(4-aminophenylsulfonyl)acetamide] bound to carboxyl group of mefenamic acid a well known nonsteroidal anti-inflammatory drugs (NSAIDs) were designed and synthesized for evaluation as a potential anti-inflammatory agent.  In vivo acute anti-inflammatory activity of the final compounds (9, 10 and 11) was evaluated in rat using egg-white induced edema model of inflammation in a dose equivalent to (7.5mg/Kg) of mefenamic acid. All tested compounds produced a significant reduction in paw edema with respect to the effect of propylene glycol 50% v/v (control group). Moreover, the 4-amino-N-methylbenzenesulfonamide derivative (c

Background: Ulcerative colitis has been reported to be associated with autonomic dysfunction, mainly of vagal involvement.

Objectives: To Determine whether there is a parasympathetic dysfunction in ulcerative colitis patients in remission state or not.
Results: For all of the three tests, patients group gave significantly lower results (P˂ 0.05) which was the least level of significance.  Materials and methods: Three standardized tests of parasympathetic function, based on heart rate variation in response to certain stimuli (heart rate response to Valsalva maneuver, to deep breathing and to standing from supine  position) were used on 54 ulcerative

Compaction curves are widely used in civil engineering especially for road constructions, embankments, etc. Obtaining the precise amount of Optimum Moisture Content (OMC) that gives the Maximum Dry Unit weight g_dmax. is very important, where the desired soil strength can be achieved in addition to economic aspects.

In this paper, three peak functions were used to obtain the OMC and g_dmax. through curve fitting for the values obtained from Standard Proctor Test. Another surface fitting was also used to model the Ohio’s compaction curves that represent the very large variation of compacted soil types.

The results showed very good correlation between the values obtained from some publ

This study included the preparation of the dihalogens -1,3 metalla-2[3] ferrocenophanes
like Cp2NbS2Fc,(tBuCp)2NbS2Fc,Cp2NbSe2Fc and (tBuCp)2NbSe2Fe where (Fc=ferrocence)
These complexes has been prepared from the reaction of (R)2 NbCl2 with FCLiM2 ,
where(R=Cp,tBuCp) (M = S,Se) under refluxing in toluene,the reaction was carried under
Argon atmosphere .
These complexes were characterized by elemental microanalysis ,Masse spectra scopy,
nuclear magnetic resonance (
1
HNMR) and melting points .

 A new series of Sulfamethoxazole derivatives was prepared and examined for antifibrinolytic and antimicrobial activities. Sulfamethoxazole derivatives bear heterocyclic moieties such as 1,3,4-thiadiazine {3},  pyrazolidine-3,5-diol {4} 6-hydroxy-1,3,4-thiadiazinane-2-thione {5} and [(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)diazenyl] {8}. Their structures were elucidated by spectral methods (FT-IR, H¹-NMR). Physical properties are also determined for all compound derivatives.  Recently prepared compounds were tested for their antimicrobial activity in the laboratory. Each screened compound showed good tendency to moderate antimicrobial activity.

In this paper, we define two operators of summation and summation-integral of q-type in two dimensional spaces. Firstly, we study the convergence of these operators and then we prove Voronovskaya- type asymptotic formulas for these operators.

        In this paper, the necessary optimality conditions are studied and derived for a new class of the sum of two Caputo–Katugampola fractional derivatives of orders (α, ρ) and( β,ρ) with fixed the final boundary conditions. In the second study, the approximation of the left Caputo-Katugampola fractional derivative was obtained by using the shifted Chebyshev polynomials. We also use the Clenshaw and Curtis formula to approximate the integral from -1 to 1. Further, we find the critical points using the Rayleigh–Ritz method. The obtained approximation of the left fractional Caputo-Katugampola derivatives was added to the algorithm applied to the illustrative example so that we obtained the approximate results for the stat

Cumulative lifetime lead (Pb) exposure has been associated with accelerated declines in cognition through the free radical generation and epigenetic effects. Several pieces of literature have identified a correlation between exposure to lead and neurodegenerative disorders. Harwich strain Drosophila melanogaster was exposed to lead acetate for two weeks, and changes in pulse transmission by acetylcholinesterase and systemic redox were evaluated. Besides, molecular docking studies of acetylcholinesterase against Quercetin and its most common derivatives contained in food have been performed. Pharmacokinetic studies on Quercetin and its derivatives have also been performed in silico toxicity. The data obtained showed alterations in antioxi