Coronary artery disease (CAD) is the leading cause of death worldwide. Certain genetic polymorphisms play an important role in this multifactorial disease, being linked with increased risk of early onset CAD.
To assess six genetic polymorphisms and clinical risk factors in relation to early onset nondiabetic Iraqi Arab CAD patients compared to controls.
This case–control study recruited 40 Iraqi patients with early onset CAD and 20 healthy controls. Demographic and clinical data were reported. Six genetic variants were tested:
The majority of patients were older males (85%), nonsmokers (52.5%), hypertensives (57.5%), had dyslipidemia (100%), and had a family history of ischemia (77.5%). This contrasts the findings in the control group (
This study aids in CAD risk stratification. There is a need for longitudinal studies assessing more genetic risks to CAD as a national CAD preventive program for high-risk Iraqi people.
