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Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism
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Background: Hypothyroidism is the most abundant thyroid disorder worldwide. For decades, levothyroxine was the main effective pharmacological treatment for hypothyroidism. A variety of factors can influence levothyroxine dose, such as genetic variations. Studying the impact of genetic polymorphisms on the administration of medications was risen remarkably. Different genetic variations were investigated that might affect levothyroxine dose requirements, especially the deiodinase enzymes.  Deiodinase type 2 genetic polymorphisms’ impact on levothyroxine dose was studied in different populations. Objective: To examine the association of the two single nucleotide polymorphism (SNP)s of deiodinase type 2 (rs225013 and rs225014) and levothyroxine dose requirements. Subjects and Methods: A cross-sectional study was conducted at Baghdad Center for Nuclear Medicine and Radiation Therapy located in Baghdad/ Iraq, from March to June 2022. Based on levothyroxine dose, the enrolled patients were divided into two groups: low dose group < 1.7 µg/kg/day and high dose group ≥ 1.7 µg/kg. Then genotyping analysis was done for both groups of the study. Results: The mean age of the participants was 40.35 ± 9.5 years with a mean body mass index of 30.61 ± 5.72 kg/m2. The mean levothyroxine doses in the low- and high-dose groups were 81.67 ± 30.74 µg/day and 161.67 ± 35.19 µg/day, respectively. Significant differences existed in the levels of TSH and TT4 between the study’s groups. Conclusion: This study indicated that the differences in levothyroxine dose, TSH, TT4 and TT3 levels were not associated with the DIO2 rs225013. Similarly, the differences in TSH, TT3 and TT4 levels revealed a non-significant association with DIO2 rs225014 except for levothyroxine dose which was higher in the patients who carried the wild type allele (TT).

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Publication Date
Thu Sep 13 2018
Journal Name
Baghdad Science Journal
On Soft Turning Points
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The soft sets were known since 1999, and because of their wide applications and their great flexibility to solve the problems, we used these concepts to define new types of soft limit points, that we called soft turning points.Finally, we used these points to define new types of soft separation axioms and we study their properties.

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Publication Date
Tue Mar 01 2011
Journal Name
Journal Of Economics And Administrative Sciences
Notes on Weibull Distribution
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Weibull Distribution is one of most important distribution and it is mainly used in reliability and in distribution of life time. The study handled two parameter and three-parameter Weibull Distribution in addition to five –parameter Bi-Weibull distribution. The latter being very new and was not mentioned before in many of the previous references. This distribution depends on both the two parameter and the three –parameter Weibull distributions by using the scale parameter (α) and the shape parameter (b) in the first and adding the location parameter (g)to the second and then joining them together to produce a distribution with five parameters.

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Publication Date
Mon Mar 01 2021
Journal Name
Journal Of Physics: Conference Series
On Small Semiprime Submodules
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Abstract<p>Let R be a commutative ring with identity, and M be unital (left) R-module. In this paper we introduce and study the concept of small semiprime submodules as a generalization of semiprime submodules. We investigate some basis properties of small semiprime submodules and give some characterizations of them, especially for (finitely generated faithful) multiplication modules.</p>
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Publication Date
Sun Sep 04 2011
Journal Name
Baghdad Science Journal
On Primary Multipliction Modules
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Let R be a commutative ring with identity and M be a unitary R- module. We shall say that M is a primary multiplication module if every primary submodule of M is a multiplication submodule of M. Some of the properties of this concept will be investigated. The main results of this paper are, for modules M and N, we have M N and HomR (M, N) are primary multiplications R-modules under certain assumptions.

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Publication Date
Sun Mar 01 2020
Journal Name
Baghdad Science Journal
On S*-Supplemented Modules
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The main goal of this paper is to introduce and study a new concept named d*-supplemented which can be considered as a generalization of W- supplemented modules and d-hollow module. Also, we introduce a d*-supplement submodule. Many relationships of d*-supplemented modules are studied. Especially, we give characterizations of d*-supplemented modules and relationship between this kind of modules and other kind modules for example every d-hollow (d-local) module is d*-supplemented and by an example we show that the converse is not true.

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Publication Date
Fri May 01 2020
Journal Name
Journal Of Physics: Conference Series
On J–Lifting Modules
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Abstract<p>Let R be a ring with identity and M is a unitary left R–module. M is called J–lifting module if for every submodule N of M, there exists a submodule K of N such that <inline-formula> <tex-math><?CDATA ${\rm{M}} = {\rm{K}} \oplus \mathop {\rm{K}}\limits^\prime,\>\mathop {\rm{K}}\limits^\prime \subseteq {\rm{M}}$?></tex-math> <math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="block" overflow="scroll"> <mrow> <mi mathvariant="normal">M</mi> <mo>=</mo> <mi mathvariant="normal">K</mi></mrow></math></inline-formula></p> ... Show More
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Publication Date
Sun Dec 05 2010
Journal Name
Baghdad Science Journal
ON M- Hollow modules
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Let R be associative ring with identity and M is a non- zero unitary left module over R. M is called M- hollow if every maximal submodule of M is small submodule of M. In this paper we study the properties of this kind of modules.

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Publication Date
Wed Mar 30 2022
Journal Name
Iraqi Journal Of Science
On Annihilator-Extending Modules
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    Throughout this work we introduce the notion of Annihilator-closed submodules, and we give some basic properties of this concept. We also introduce a generalization for the Extending modules, namely Annihilator-extending modules. Some fundamental properties are presented as well as  we discuss the relation between this concept and some other related concepts.

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Publication Date
Sun Dec 07 2008
Journal Name
Baghdad Science Journal
On CSO-Compact Space
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The aim of this paper is to introduces and study the concept of CSO-compact space via the notation of simply-open sets as well as to investigate their relationship to some well known classes of topological spaces and give some of his properties.

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Publication Date
Mon Apr 04 2016
Journal Name
Journal Of Advances In Mathematics
ON CJ-TOPLOGICAL SPACES
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