Preferred Language
Articles
/
uhdljJIBVTCNdQwCWbV8
Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery
...Show More Authors

Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for the treatment of schizophrenia. Its oral bioavailability is 60% due to its low solubility and pre-systemic metabolism. Hence, the present work aims to formulate and evaluate OLZ nanoparticles dissolving microneedles (MNs) for transdermal delivery to overcome the problems associated with drug administration orally. OLZ nanoparticles were prepared by the nanoprecipitation method. The optimized OLZ nanoparticle formula was utilized for the fabrication of dissolving MNs by loading OLZ nanodispersion into polydimethylsiloxane (PDMS) micromould cavities, followed by casting the polymeric solution of polyvinylpyrrolidone(PVP-K30) and polyvinyl alcohol (PVA) to form MN matrix. The results revealed that the optimized OLZ nanoparticle formula (NP-5) exhibited particle size 115.76±5.45 nm, entrapment efficiency 78.4±5.46, and zeta potential -19.01±1.6 mV. The results of MNs revealed that MN-4 exhibits a high drug content of 98.52%, and ex vivo permeation through rabbit skin exhibited that MN-4 permeates more effectively than a simple patch by approximately 5.16 fold. In vivo pharmacokinetics study revealed that the area under curve AUC 0-∞ of MN-4 was 6054.56±376 ng. h/ml as compared with AUC0-∞ of marketed OLZ tablet was 3975.77±373 ng. h/ml. It can be concluded that the dissolving MN-4 patch is considered a promising formula to overcome the problems associated with drug administration orally and could improve drug bioavailability, in addition to the ease of administering the medication to schizophrenic patients.

Scopus Clarivate Crossref
View Publication
Publication Date
Thu May 05 2022
Journal Name
Al-kindy College Medical Journal
Possible role of Spironolactone in a sample of Iraqi patients with acute central serous chorioretinopathy: Spironolactone in acute csr
...Show More Authors

Background: Central serous chorioretinopathy (CSCR) is an idiopathic condition aggravated by exogenous or endogenous glucocorticoids. Vascular deregulation in the choroid is a new hypothesis regarding central serous chorioretinopathy occurrence. The inhibition of choroidal mineralocorticoid receptors has a great role in shortening the duration of CSCR by inhibiting choroidal vasodilatation and leak.

Objective:  To assess the effect of oral spironolactone on subretinal fluid, central macular thickness and visual acuity in patients with acute CSCR compared to observation.

Subjects and Methods:  a hospital based, randomized clinical trial carried out at outpatient clinic in Ibn-Alhaitham Teaching E

... Show More
View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Tue Jun 16 2020
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Spectrum of Chest Computed Tomography findings of Novel Coronavirus disease 2019 in Medical City in Baghdad, a case series
...Show More Authors

Background: Native chest Computed Tomography (CT) is a quick, non-invasive and practical investigation & plays an important role in evaluation of Coronavirus Disease 2019.

Objective: to describe the chest CT findings in patients with confirmed coronavirus disease 2019 (COVID-19) in sample from Baghdad population.

Patients & methods: Study sample consisted of 55 patients with laboratory confirmed COVID-19 from 1st March through 15th April 2020. Native chest CT was performed in radiology departments in Medical City Teaching Complex (MCTH). The chest CT images were reviewed & analyzed.

Results: The most frequent CT findings were ground-glass opacities (47.3%) & mixed ground glass

... Show More
View Publication Preview PDF
Crossref (2)
Crossref
Publication Date
Mon Jan 28 2019
Journal Name
Journal Of The College Of Education For Women
The measurement of Ibn Abi al-Rabee (688 AH) in his book (Abstract in the regulation of Arabic laws)
...Show More Authors

The book of the summary in the control of the laws of Arabic is one of the most important books of Andalusian grammar, the resonance of which is clearly evident among the mother of the language books in the seventh century AH because of the character of the educational style easy and simplified service for anyone who wants the Nile Arabic grammar, that end through what is pursued in his book (Summary) on according to visual standards, as was Ibn Abi Al-Rabeea of first- type, and illustrated in which he addressed the analogies, and he followed the modalities expressed and its consequences relating to each attachment in which a (illness and reasoning factor) And what he said in the framework of each service for the study material in his ha

... Show More
View Publication Preview PDF
Publication Date
Wed May 08 2024
Journal Name
Babylon: Abjad Publising House
“Translation is the Art of Negotiating with Words”, in Hassad aS-Sineen(Harvest of Years): Essays in Teaching Translation
...Show More Authors

Publication Date
Sat Sep 01 2018
Journal Name
International Journal Of Heat And Mass Transfer
Accelerated melting of PCM in energy storage systems via novel configuration of fins in the triplex-tube heat exchanger
...Show More Authors

View Publication
Scopus (242)
Crossref (235)
Scopus Clarivate Crossref
Publication Date
Sun Aug 30 2020
Journal Name
Journal Of Economics And Administrative Sciences
Comparison of the performance of some r- (k,d) class estimators with the (PCTP) estimator that used in estimating the general linear regression model in the presence of autocorrelation and multicollinearity problems at the same time "
...Show More Authors

In the analysis of multiple linear regression, the problem of multicollinearity and auto-correlation drew the attention of many researchers, and given the appearance of these two problems together and their bad effect on the estimation, some of the researchers found new methods to address these two problems together at the same time. In this research a comparison for the performance of the Principal Components Two Parameter estimator (PCTP) and The (r-k) class estimator and the r-(k,d) class estimator by conducting a simulation study and through the results and under the mean square error (MSE) criterion to find the best way to address the two problems together. The results showed that the r-(k,d) class estimator is the best esti

... Show More
View Publication Preview PDF
Crossref
Publication Date
Wed Feb 01 2023
Journal Name
Baghdad Science Journal
Bacterial Diversity in Different Positions in the Iraqi Marine Area
...Show More Authors

Microorganisms establish both structural and functional construction in the marine environment, despite scientific advances, the identification of marine bacterial species is still considered as a common challenge in microbiology. Nevertheless, the present study aims to make an effort, although it seems modest, but it could establish a basis for studying the bacterial diversity in the Iraqi marine area, because of what this aspect entails of the poverty of studies related to this aspect in the studied area. The current results show the marine studied area are classified within worming area, where the average temperature ranged from 23.17 to 26.17 ºC. The recorded number of bacteria was increased with temperature increasing (0.210, 0.250

... Show More
View Publication Preview PDF
Scopus Clarivate Crossref
Publication Date
Wed Jan 02 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Physiological Changes In Spirometric Parameters During Pregnancy In Iraqi Women
...Show More Authors

Background: The events in pregnancy elicit one of the best examples of selective anatomical, physiological and biochemical adaptations, with profound changes in respiratory physiology. The changes in respiratory  physiology are due to increased  size of the fetus with advance  gestation which constitutes a mechanical impediment to normal process of ventilation.

.Patients and methods: This study started from the 1st of Nov.  2009 till the 30th of Oct. 2010. pregnant women aged (16-44 years) of different weight, height and different conception from 1st, 2nd, 3rd trimester and post term were included. Spirometry was performed in Baghdad teaching hospital( pulmonary fun

... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon Oct 01 2018
Journal Name
Journal Of Economics And Administrative Sciences
Knowledge Management in Saudi Universities Applied study in Shaqra University
...Show More Authors

  This research aims  to know the reality of  implementation of  Knowledge Management in Saudi Universities Applied  in Shaqra University and to study the difficults whish encountered in applying the Knowledge Management approach.

The study investigated the university staff  in Shaqra, Thadig, and Huraymila branches,  using a questionnaire designed by the researcher to collect the data, sample of (260) members was used, applying the descriptive analytical approach to test the hypothesis by using (SPSS) program.

The study revealed that the first four zero hypothesis are rejected because there is medium approval of the university members on the fo

... Show More
View Publication Preview PDF
Crossref
Publication Date
Tue Jan 01 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Respiratory Distress Syndrome in Neonatal Care Units in Medical City
...Show More Authors

Introduction:
Neonatal Respiratory distress syndrome (RDS) remains one of the major cause's neonatal morbidity and mortality despite advances in perinatal care especially in developed
countries.
Objectives:
The aims of this study were to find out me risk factors of mothers and newborns (NB) which increase the incidence, morbidity, and mortality of RDS.
Patients & Methods:
A prospective descriptive cross-sectional study was conducted on 100 live NR infants born at neonatal care units in Baghdad hospital & private nursing home (medical city
complex) / Baghdad in the period from the first of March to the end of June 2006. They were presented with RDS, which was diagnosed clinically and radio-

... Show More
View Publication Preview PDF
Crossref