Cerebellum (cb) is the most important and sensitive part of the central nervous system (CNS) after cerebrum. The exposure to any infection during embryogenesis produces abnormalities in the cerebellum function and morphology that effect on behavioral of offspring later. In the present study we used 30 mature female pregnant albino rats divided in to three groups, each group contain 10 females: G1 was considered the control group received D.W only, while G2 group treated orally with (2mg/kg /day) suspension of silver nanoparticles (AgNPs) and G3 group treated orally with (20mg/kg/day) AgNPs. The embryos retrieved in different embryonic days from ED12 to ED21. In this study morphometric analysis was measured in the developing albino rats cerebellum after maternal exposure to two concentrations of AgNPs from preimplantation period until delivery . we measured the morphometric parameters (area, perimeter, anterior-posterior diameter APD and transverse diameter TD) of the selected embryonic days; ED12,ED15,ED18, and ED21 and retrieved the embryos from these days. The morphometric results in the control group(G1) showed that increased significantly (P≤ 0.05) in the area of the developing cerebellum from ED12 until reach the optimal level in the end of gestation at ED21 (14.0815mm2 to 18.969 mm2 respectively), perimeter (9.804 mm2 to 16.267 mm2) and TD (52.6308μm to 431.6 μm),while the APD value was increased significantly (P≤ 0.05) at ED12 and ED15 only (367.0041 μm, 454.011 μm )respectively but the orientation growth of the cerebellum decreased significantly (P≤ 0.05) at the later stage of the development at ED18 and ED21(364.48 μm, 225μm) respectively. In the present research both concentrations of the AgNPs (2mg and 20 mg/kg/ B.Wt) showed changes in the dimensions of the developing cerebellum cortex according to the studied morphometric parameters; in the 2 mg/kg/ B.Wt, the area of the developing cerebellum cortex was increased significantly (P≤0.05) from ED12 (47.437mm 2) and reached to maximum growth at ED18 (130.220 mm2), while it is growth inhibited at ED21( 68.909 mm2) compared to control group, the values of the developing cerebellum cortex perimeter increased significantly (P≤0.05) from ED12 until ED15 (0.964 mm 2, 2.548 mm 2) respectively compared to control group; TD values of the developing cerebellum cortex increased significantly (P≤0.05) from ED12 until ED15 also (259.341 μm,436.203 μm) respectively compared to control group. While the APD of the developing cerebellum cortex was decreased significantly (P≤0.05) during late development of the cortex at ED18 and ED21(330.415 μm, 131.5 μm) respectively as in the control group. In G3 group which treated with 20mg/kg/ B.Wt concentration of AgNPs, the similar results of area were showed as in the lower concentration, area of the developing cortex increased significantly (P≤0.05) from ED12(80.11mm 2) and reached to maximum growth at ED18(140.56 mm2) and lower after that. the values of the developing cerebellum cortex perimeter increased significantly (P≤0.05) from ED12 until ED15 (0.256 mm2, 0.543 mm2) respectively compared to control group; while in the APD and TD values the effect of the higher concentration of the AgNPs was more effect on these dimensions; APD values decreased significantly (P≤0.05) at ED15 (360.48 μm ) and not reach to the complete growth, also in TD values decreased at ED15 (400.5744 μm) and do not reach to maximum growth at end embryonic development compared to the embryonic development timing in the control group.
Sustainable development (SD) is an improvement that meets present needs but jeopardizes the ability of new populations to do the same. It is vital to acquaint EFL students with the terminology and idiomatic expressions of this discipline. Nowadays, sustainable development and the environment have been prioritized in every aspect of life. Since culture and the teaching of Foreign language English cannot be separated, the English language becomes the mean of communication in health, economics, education, and politics. Thus, integrating sustainable development goals within language learning and teaching is very important. This descriptive quantitative study aims to investigate the perception of EFL pre-service teachers of sustainable develo
... Show MoreBackground: Morphological and histological examination of the testes can provide a suitable insight into the health of the reproductive system. Aim: The objective of the current study was to investigate the morphological and histological features of the testes of local pigeons (Columba livia domestica) at mature and immature stages of age. Methods: Two groups of collected specimens underwent macroscopic and microscopic investigation to evaluate and compare the main general properties of their testes. Results: The findings indicated that the testis has an oval shape in both pre-puberty and post-puberty stages, situated on the inner side of the kidney towards the caudal extreme of the lungs. However, the left testis was bigger than those on t
... Show MoreThe primitive streak and notochord and previously the anterior marginal crescent (AMC), anterior visceral endoderm (AVE) and the anterior hypoblast (AHB) are embryonic entities which identify main body axes and thus establish body plan in the early stages of embryonic development. All of the anterior pre-gastrulation differentiation structures are addressed terminology as anterior pre-gastrulation differentiation (APD). These structures are defined morphologically and are called in mouse (AVE), in rabbit (AMC) and in the pig (AHB). The anterior hypoblast cells of APD are higher and denser than at the opposite pole of the embryo. Moreover, the APD stretches variously between species and has different shapes in the mammalian embryos, for exam
... Show MoreDrug –induced nephrotoxicity is an important cause of renal failure. Aminoglycoside antibiotics, such as amikacin, which causes ototoxicity and nephrtotoxicity as a main side effects, this is focused on the use of natural materials as antioxidants against the toxic oxidative action that exert a cell damaging effect. The most important one of these materials is the honey. The aim of this work is to evaluate the antioxidant effects of honey against amikacin – induced nephrotoxicity.18 albino rats divided into 3 groups (6 rats per each group), group 1 received I.P daily dose of normal saline (control), group 2 received (35 mg/kg/day) I.P dose of amikacin ,and group 3 received (35mg/kg/day) of amikacin I.P dose in combina
... Show MoreDrug-induced acute kidney injury is a serious disorder. Oxidative stress has a key role in its initiation and progression. In this study, the possible ameliorative effect of fimasartan against methotrexate-induced nephrotoxicity was investigated in comparison with α-tocopherol in rats. Wistar rats were allocated into six groups and treated as follows: group Ӏ received water on a daily basis for 8 successive days; group ӀӀ received methotrexate (20 mg/kg) on day 1, followed by water for 7 successive days; group ӀӀӀ received fimasartan (3 mg/kg/day) for 7 successive days; group IV received α-tocopherol (1 g/kg/day) for 7 successive days; group V re
... Show MoreA great deal of attention has recently been given to the use of polyvinyl alcohol and its suitably modified derivatives as aqueous and coating phase corrosion inhibitors because of their polymeric nature, relatively high aqueous phase solubility, and biodegradable properties. The purpose of this study was to investigate the thermal stability and inhibition efficiency of modified polyvinyl alcohol/carboxymethyl cellulose. Gold or silver nanoparticles were used to accomplish this goal. In the current study, polyvinyl alcohol reacted with newly synthesized compounds [I-VI] in DMF to produce modifications of polyvinyl alcohol [VII-XII]. To create [XIII-XVIII], modified polyvinyl alcohol is blended with carboxymethyl cellulose. Then, ble
... Show MoreThe present study aimed to explain the dose-dependent possible deleterious effects of 30 day administration of Tramadol on some hematological and biochemical parameters of laboratory male rats (Rattus norvegicus), the study consisted of eighteen adult male rats randomly divided into three equal groups (each of six). Group 1 (control) were treated by intraperitoneal injection of normal saline solution (0.2 ml), group two (low dose) was treated by intraperitonealy (i.p) injection of Tramadol at a dose of 50 mg/kg/day, group three (high dose) was treated by intraperitonealy injection of Tramadol at a dose of 100 mg/kg/day for 30 days. At the end of experimental period, rats were sacrificed. Blood were collected by cardiac puncture to inv
... Show MoreIt is obvious that the constitutional- political structures which has been emerged in Iraq after the occupation in 2003 frame worked by many sectarian, ethnic, tribal and political orientations, pushing forewords to escalating the contradictions between social- political powers, however, these changes unfortunately result not just destroy and taking apart the political regime and his authority, but the state and his institutions as well, although, did not stamped as wise and rational change for better future to new Iraq and its political, civil and military institutions. Finally, as quick as Iraq start to bisects to sectarian, ethnic and national components according to the new political – social components of Iraq. Indeed, what is req
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