Spectrophotometric Estimation of Methyldopa Drug in pure and pharmaceutical formulations

Saba Salman; Husam Saleem Khalaf

doi:10.21608/EJCHEM.2024.248561.8873

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Publication Date

Wed Feb 07 2024

Journal Name

Egyptian Journal Of Chemistry

Issue Number

8

DOI

10.21608/EJCHEM.2024.248561.8873

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Spectrophotometric Estimation of Methyldopa Drug in pure and pharmaceutical formulations

Methyldopa

Spectrophotometry

Sodium nitrite

Metoclopramide

Sulfamic acid.

Saba Salman

Husam Saleem Khalaf

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Publication Date

Sun Mar 26 2017

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

Bioequivalence and Pharmacokinetics Comparison of Two Formulations of Extended-Release Pentoxifylline Tablets in Healthy Subjects after Fasting and Fed Conditions

Jaafar

...Show More Authors

The pharmacokinetics and bioequivalence of a newly developed extended-released (ER) tablet containing 400 mg pentoxifylline as a test product was compared with the reference brand product Trental^Â® 400 mg ER tablet produced by Sanofi-Aventis. Two separate studies were conducted simultaneously. The first study was conducted under fasting condition, whereas, the second study was conducted under fed condition; using the same batches of the test and reference products in both studies. In each study, both products were administered to 32 healthy male adult volunteers applying a single-dose, two-treatment, two-period, two-sequence, randomized crossover design with one-week washout period between dosing. Twenty two blood samples we

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(3)

Publication Date

Sun Sep 06 2009

Journal Name

Baghdad Science Journal

Spectrophotometric Study of ?-Irradiated PM-355

"PM-355

Spectrophotometric study-irradiated PM-355

High doses dosimeters"

Nahida J.H.

Nada F.

Mohammed T. Abdul

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The aim of the present work is concerned with the effect of ?-irradiation on PM-355 with absorbed dose of (30-160Mrad) range. This polymer is evaluated spectrophotometrically for use as high dose dosimeters. The absorption spectra of irradiated samples showed radiation induced absorption changes. There is an increment in absorption proportional with absorbed dose. This increment is attributed to interfaces traps which, are formed by irradiation. Calibration curve was drawn .The linear relation was found in calibration curve, and dosimeter range was determined from the linear part. The linearity in response curve suggested that PM-355 could be used as dosimeter within (30-160Mrad) rang. Energy gap shift was used as a second tool to determin

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Publication Date

Mon Dec 30 2002

Journal Name

Iraqi Journal Of Chemical And Petroleum Engineering

Aerobic Filter Treatment of Pharmaceutical Waste

Nahidh W

Hammodi A

Kassim H

Abbas H

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Publication Date

Mon Feb 14 2022

Journal Name

Proceedings Of The National Academy Of Sciences

Pharmaceutical pollution of the world’s rivers

John L.

Alistair B.A.

Dana W.

Kenneth M. Y.

Racliffe W. S.

Cristóbal

Aiko D.

Julie

Marc

Robert A.

Alejandra

Aida

Anja

Pedro

Macarena

Chris

Magdalena

Monique

Thais

Vahagn

Yekaterina

Clare S.

Christopher J.

Thilo

Tapos

Volga

Jessica

Jean L.

Francisco

Maria T. P.

Victorien

Gildas

Oumar

Jules M.

Linda E.

Michelle

Donald

Romaric

Jaime

Guang-Guo

Chang-Er

Martha

Jina

Jean-Paul

John

Suspense A.

Penelope

Silvia

Nikolina

Milena

Despo

Lida

Vladimíra

Jan

María

Bayable A.

Jeanne

Arnaud

Peter

Ilia

Sven

Gerasimos

Halldór P.

Molly

Thatikonda

Manisha

Anindrya

Adee

Nima

Ali

Omar

Salem S.

Francesco

Benny

Tom

Koffi Marcellin

Bakhyt

Raikhan

Lydia

Jemimah K.

Peter

Victor

Nathaniel T.

Sheck

Ahmad Zaharin

Ley Juen

Mahamoudane

Seydou T.

Rik

Olatayo

Muhammad

Ziad

Aaron

Jorge Manuel

María

Heidi

Ian

Fabio

Alhaji Brima

Bashiru M.

Vesna

Mitja

Melusi

Kyungho

Habyeong

John L. Celestino

Andreu

Priyanie

Anna

Gisela

Armin K.

Alex C.

Jheng-Jie

Rebecca

Madaka

Ulas

Turgut T.

Julius B.

Yuliya

Yuriy

Horacio

Andrés

Douglas B.

Maritza

David

Charles

...Show More Authors

Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across

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Publication Date

Mon Mar 25 2019

Journal Name

Al-academy

The Effectiveness of Implication in New Formulations of the Contemporary Industrial Product: زياد حاتم حربي

Effectiveness of Implication

Contemporary Industrial Product

Ziad

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The current research aims at transforming the concept of implication from the rhetoric into the industrial design in order to have a new term (the design implication) in which the industrial designer takes all or part of another's design to imply his design in it and acknowledge that, and if he did not do so, it would be (design theft) parallel to the literary plagiarism.
In order to show the potentials of the industrial design in the production of new formulations of the industrial products forms, as the design is the carrier of language that addresses the recipients, it is possible to use the implication as a the tool of literature in the design and as a design strategy as it is one of the concepts that takes its course in e

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Publication Date

Fri Dec 01 2023

Journal Name

Baghdad Science Journal

Simultaneous Determination of Binary Mixture of Estradiol and Progesterone Using Different Spectrophotometric Methods

Absorbance ratio method

Derivative spectrophotometry

Estradiol

Progesterone

Ratio subtraction.

Dashty K.

Nabil A.

Chnar M.

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Four rapid, accurate and very simple derivative spectrophotometric techniques were developed for the quantitative determination of binary mixtures of estradiol (E2) and progesterone (PRG) formulated as a capsule. Method I is the first derivative zero-crossing technique, derivative amplitudes were detected at the zero-crossing wavelength of 239.27 and 292.51 nm for the quantification of estradiol and 249.19 nm for Progesterone. Method II is ratio subtraction, progesterone was determined at λmax 240 nm after subtraction of interference exerted by estradiol. Method III is modified amplitude subtraction, which was established using derivative spectroscopy and mathematical manipulations. Method IIII is the absorbance ratio technique, absorba

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(1)

Publication Date

Sun Jan 01 2023

Journal Name

Journal Of Complementary Medicine Research

Principles and Advantages of New Drug Delivery Technologie

Hussein

Ahmed

Salam

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Advanced drug delivery systems offer undeniable benefits for drug delivery. In the past three decades, new methods have been proposed to develop a novel carriers for drug delivery. Nowadays, the major goal is to maximize therapeutic benefit while minimizing side effects. Drug delivery technique is clearly shifting from the micro to nanoscale. Nano-drug delivery systems (NDDSs) are the most promising approach utilized to improve the accuracy of drug delivery and the efficacy of drugs.In this narrative review article, we evaluate how delivery challenges associated with commercial marketed products and discuss newer DDS is being carried out to overcome these challenges .Different colloidal carrier systems such as carbon nanotube ,li

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(2)

Publication Date

Thu Dec 01 2022

Journal Name

Baghdad Science Journal

Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form

Caffeine

Ibuprofen

Paracetamol

Peak area

Ratio derivative

Khalaf F.

Suham Tawfeq

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A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and second ratio derivative spectrum using a double devisor. Par, Ibu, and Caf showed many useful peaks for their quantified determination. The validity of all analysis modes for determination of the three compounds, peak to baseline, peak area and peak to peak were according to ICH. The linearity of two methods was between 5 µg/ml as a lower concentration and 50 µg/ml as the highest concentration for three compounds. Recovery percentage was around 100% and relative standard deviation was less than 2.6%. The methods were applied successfully in the

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Publication Date

Wed Jan 01 2025

Journal Name

Journal Of Advanced Pharmacy Education And Research

Ultra HPLC method development and validation for the determination of meclizine in pharmaceutical formulation

Omar Saeb

Saba Abdulhadi

Halah Talal

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(1)

Publication Date

Wed Feb 01 2023

Journal Name

Baghdad Science Journal

Spectrophotometric Method Combined with HPLC for Bisphenol F Determination in Plastic Bottled Water and Thermal Paper

Bisphenol F

Diazotization-Coupling Reaction

HPLC

Metoclopramide

Spectrophotometric Technique

Narjes Mohanad

Maha

Mohanad Lateef

Nahlah Kadhim

Hawraa Mahmood

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Based on the diazotization-coupling reaction, a new, simple, and sensitive spectrophotometric method for determining of a trace amount of (BPF) is presented in this paper. Diazotized metoclopramide reagent react with bisphenol F produces an orange azo-compound with a maximum absorbance at 461 nm in alkaline solution. The experimental parameters were optimized such as type of alkaline medium, concentration of NaOH, diazotized metoclopramide amount, order additions, reaction time, temperature, and effect of organic solvents to achieve the optimal performance for the proposed method. The absorbance increased linearly with increasing bisphenol F concentration in the range of 0.5-10 μg mL^-1 under ideal conditions, with a correlati

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