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The clinical spectrum of cutaneous leishmaniasis (CL), an intracellular parasitic pathogen, ranges from a single
sore healing to chronic crusty lesions with a manifestation of treatment resistance. The complicated interaction
between Leishmania bodies and the early immune response, including innate and adaptive mechanisms, determines
the evolution of nodules. This study examined the levels of the chemoattractant interleukin 8 (IL-8),
pro-inflammatory nitric oxide (NO), and immunoregulatory macrophage inhibitory factor (MIF) in the serum of
subjects recently diagnosed with cutaneous leishmaniasis, in parallel with patients being monitored during
consecutive sodium stibogluconate (Pentostam) treatment. A total of 161 serum samples of newly di
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