Preferred Language
Articles
/
lRcCBo4BVTCNdQwCTy_c
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
...Show More Authors
Abstract<p>Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune cells from renal clear cell carcinoma (ccRCC) patients, we identify two distinct transcriptional fates for TI Treg cells, Fate-1 and Fate-2. The Fate-1 signature is associated with a poorer prognosis in ccRCC and several other solid cancers. CD177, a cell surface protein normally expressed on neutrophil, is specifically expressed on Fate-1 TI Treg cells in several solid cancer types, but not on other TI or peripheral Treg cells. Mechanistically, blocking CD177 reduces the suppressive activity of Treg cells in vitro, while Treg-specific deletion of <italic>Cd177</italic> leads to decreased tumor growth and reduced TI Treg frequency in mice. Our results thus uncover a functional CD177<sup>+</sup> TI Treg population that may serve as a target for TI Treg-specific immunotherapy.</p>
Scopus Clarivate Crossref
View Publication
Publication Date
Mon Jun 30 2003
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Study of the Factors Affecting Cells of Sodium Chlorate Production
...Show More Authors

View Publication Preview PDF
Publication Date
Mon Sep 25 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Comparison of the Suggested loss Function with Generalized Loss Function for One Parameter Inverse Rayleigh Distribution
...Show More Authors

The experiences in the life are considered important for many fields, such as industry, medical and others. In literature, researchers are focused on flexible lifetime distribution.

In this paper, some Bayesian estimators for the unknown scale parameter  of Inverse Rayleigh Distribution have been obtained, of different two loss functions, represented by Suggested and Generalized loss function based on Non-Informative prior using Jeffery's and informative prior represented by Exponential distribution. The performance of   estimators is compared empirically with Maximum Likelihood estimator, Using Monte Carlo Simulation depending on the Mean Square Error (MSE). Generally, the preference of Bayesian method of Suggeste

... Show More
View Publication Preview PDF
Publication Date
Sun Sep 22 2019
Journal Name
Baghdad Science Journal
Estimation of Survival Function for Rayleigh Distribution by Ranking function:-
...Show More Authors

In this article, performing and deriving te probability density function for Rayleigh distribution is done by using ordinary least squares estimator method and Rank set estimator method. Then creating interval for scale parameter of Rayleigh distribution. Anew method using   is used for fuzzy scale parameter. After that creating the survival and hazard functions for two ranking functions are conducted to show which one is beast.

View Publication Preview PDF
Scopus (5)
Crossref (2)
Scopus Clarivate Crossref
Publication Date
Sat Dec 24 2022
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
The Effect of TNF-Alpha Gene Polymorphisms At -376 G/A, -806 C/T, and -1031 T/C on The Likelihood of Becoming a Non-Responder to Etanercept in A Sample of Iraqi Rheumatoid Arthritis Patients
...Show More Authors

Tumor necrosis factor-alpha (TNF-α) antagonists’ therapy are expensive and has a non-responsive rate between 30% to 40% in rheumatoid arthritis patients. Genetic variation plays a vital role in the responsiveness to this type of therapy.The aim of this study is to investigate if the presence of genetic polymorphism in the TNF-α gene promoter region at locations -376 G/A (rs1800750), -806 C/T (rs4248158), and -1031 T/C (rs1799964) affects rheumatoid arthritis patient's tendency to be a non-responder to etanercept.

Eighty RA patients on etanercept (ETN) for at least six months were recruited from the Rheumatology Unit at Baghdad Teaching Hospital. Based on The European League Against Rheumatism response (EULAR) criteria, patient

... Show More
View Publication Preview PDF
Scopus (7)
Crossref (4)
Scopus Crossref
Publication Date
Mon May 11 2020
Journal Name
Baghdad Science Journal
New Concepts of Fuzzy Local Function: Types of fuzzy local function
...Show More Authors

The main idea of this paper is to define other types of a fuzzy local function and study the advantages and differences between them in addition to discussing some definitions of finding new fuzzy topologies. Also in this research, a new type of fuzzy closure has been defined, where the relation between the new type and different types of fuzzy local function has been studied

View Publication Preview PDF
Scopus (13)
Crossref (10)
Scopus Clarivate Crossref
Publication Date
Sun Oct 22 2023
Journal Name
Iraqi Journal Of Science
Brain Tumor Detection of Skull Stripped MR Images Utilizing Clustering and Region Growing
...Show More Authors

Brain tissues segmentation is usually concerned with the delineation of three types of brain matters Grey Matter (GM), White Matter (WM) and Cerebrospinal Fluid (CSF). Because most brain structures are anatomically defined by boundaries of these tissue classes, accurate segmentation of brain tissues into one of these categories is an important step in quantitative morphological study of the brain. As well as the abnormalities regions like tumors are needed to be delineated. The extra-cortical voxels in MR brain images are often removed in order to facilitate accurate analysis of cortical structures. Brain extraction is necessary to avoid the misclassifications of surrounding tissues, skull and scalp as WM, GM or tumor when implementing s

... Show More
View Publication Preview PDF
Publication Date
Thu May 18 2023
Journal Name
Journal Of Engineering
The Structural systems and expressional function for Airport Terminals' buildings
...Show More Authors

The research deals with the structures of the contemporary travelers' buildings in particular, and which is a functional complex installations where flexibility, technical and stereotypes play an important role as well as the human values These facilities must represent physiological and psychological comfort for travelers. TThose are facilities where architectural form plays a distinguished role in reversing the specialty and identity of the building. Hence the importance of the subject has been in forced, as a result for the need to study these facilities and to determine the impact and affects by the surrounding environment, to the extent of the urban, environmental, urban, social, and psychological levels. The importance of the resea

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sun Sep 05 2010
Journal Name
Baghdad Science Journal
The effect of solar cells distribution on the Performance of solar panel
...Show More Authors

Three different distribution modules of silicon solar cells in a panel are used in this study . Each module consists of five identical circular silicon solar cells of radius (5cm) and then the total panel areas are identical. The five solar cells are arranged in the panel in different shapes: circular, triangular and rectangular .The efficiency for these three panel distribution are measured indoor and outdoor. The results show that the efficiency is a function of the cells distribution.

View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Sun Jan 01 2023
Journal Name
Aip Conference Proceedings
Examining the seasonal correlation between SSN, T-Isndex, and F10.7 parameters during solar cycles 23 and 24
...Show More Authors

View Publication
Scopus (1)
Scopus Crossref
Publication Date
Sun Mar 06 2011
Journal Name
Baghdad Science Journal
The influence of Packed Cells Volume (PCV) and Temperature on Erythrocytes Sedimentation Rate (ESR)
...Show More Authors

Erythrocytes aggregation is an important physiological phenomenon in the circulation of blood, and is a basic characteristic of normal blood that plays a major role in cardiovascular system especially in the microcirculation. Blood samples have been taken from (30) volunteers (15 male, and 15 female), their ages (20-30) years. The Erythrocytes Sedimentation Rate (ESR) for those subjects was measured at different Packed Cells Volume (PCV) (10%-25%), and also it was measured at different temperature (10oC-25oC). The results show that there was a highly significant decrease (P<0.01) in ESR when the PCV increase and a highly significant increase (P<0.01) in ESR when the temperatures increase. The conclusion from these results is that the ESR va

... Show More
View Publication Preview PDF
Crossref