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Fumonisin B1 is toxic secondary metabolites compound produced by Fusarium spp. on maize and maize products
causes health problems to human and animal. Therefore, this research is planned to study the effect of FB1 on the expression
of TLR-2 & 4 in liver and kidney cells of mice. Four group of male mice were orally administrated with single dose of FB1 toxin
as the following: 0 ppb, 800 ppb, 1200 ppb and 1600 ppb. After two weeks all animals were sacrificed, liver and kidney autopsies
were taken and the level of TLR-2 & 4 detected in each four group by immunohistochemistry technique (IHC). According to the
IHC examination of groups (1, 2, 3 and 4) strong expression of TLR2 in liver and kidney were (0%, 33.3%, 100%, 100%),
respectively. This
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