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Schizophrenia (ZP) is a common devastating cognitive disorder; however, the etiology
of its incidence remains largely unclear yet. Although some evidence blames both environ
ment and genetic factor as main drivers of ZP, but the clear mechanism of their effect elusive
till now. Of interest, severe anemia conditions can lead to hypoxia in CNS which disturbs
the normal structures and functions of some area in the brain resulting in abnormalities in
the neurons communications and decrease synaptic plasticity. Additionally, modulation of
cytoskeleton constituents is thought to participate to ZP development. Recently, it has been
revealed that iron deficiency, which is the main cause of anemia, has a significant impact on
the cytoskeleton
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