Background: Polycystic ovary syndrome (PCOS) is
the most common form of chronic anovulation
associated with androgen excess; it occurs in about 5
– 10% 0f reproductive age women. Metabolic
syndrome is characterized by insulin resistance,
hypertension, obesity, abnormalities of blood clotting
and dyslipidemia.
Adult women with PCOS have an increased
prevalence of the metabolic syndrome(MBS).
Objectives: To detect the prevalence of metabolic
syndrome in women with proved PCOS, attending the
Specialized Center for Endocrinology and Diabetes, in
Baghdad.
Materials and methods : A total number of 40
women with proved PCOS were included in this study
which was conducted in the Specialized Center for
Endocrinology and Diabetes-Baghdad, over a period
of 5 months(from April till September 2005).In
addition to measuring waist circumference and body
mass index(BMI),all patients were tested for the
levels of C-peptide, Fasting plasma glucose(FPG),
Serum luteinizing hormone(LH), Follicle st –
imulating hormone(FSH), Prolactin(PRL),
Progesterone, estradiol(E2), testosterone,T3,T4 and
TSH .
Also lipid profile, glycated hemoglobin(HbA1c) were
estimated to all patients. Glucose tolerance test(GTT)
using 75 gm of glucose was performed on all patients.
Results: Out of 40 women with PCOS,eleven
patients(27.5%) have impaired GTT. Twenty patients
(50%) out of 40 fulfil the criteria of the International
Diabetes Fideration(IDF)
Consensus Definition of the metabolic
syndrome(MBS)-2005.
Thirty-Seven patients(92.5%) have a waist
circumference more than 80 cm.
Thirty-two patients(80%) have secondary amenorrhea.
Hirsuitism and increased BMI(body mass index) were
present in 33 patients(82.5%)
The mean C-peptide level was higher in those patients
who had impaired GTT(11 patients),meaning that
GTT can be used to detect insulin resistance specially
in Labs. where measurements of insulin levels are not
available.
Conclusions :
1. Metabolic syndrome is present in 50% of our
patients,using the IDF Consensus Definition of
the metabolic syndrome-2005.
2. Glucose tolerance test can be used to detect the
presence of insulin resistance specially in Labs.
where measurements of insulin levels are not
available.
3. Insulin resistance is present in 27.5% in women
with PCOS who were included in our study.
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This is an autosomal dominant disease. The gene STK11 on chromosome 19 has been found in proportions of patients with this condition, this consists of: A-Intestinal hamartomatosis. B-Melanosis of the oral mucous membrane and the lips.
The high mobility group A1 gene (HMGA1) rs139876191 variant has been related to metabolic syndrome and type 2 diabetes, but data are lacking in Middle Eastern populations. The study aimed to assess whether the HMGA1 rs139876191 variant is associated with metabolic syndrome risk and whether this variant predicts the risk of insulin resistance. This case-control study was carried out at single center in Kirkuk city/ Iraq from February to August 2022. Polymorphisms in HMGA1 and genotyping were identified by Sanger sequencing of genomic DNA obtained from 91 Iraqi participants (61 patients with metabolic syndrome and 30 control). Lipid profile, serum (glucose and insulin), glycated hemoglobin, blood pressure, body mass index, and waist circumfer
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Aim: The purpose of this study is to compare the effect of epineurotomy of median nerve with just division of the transverse carpal ligament in the treatment of carpal tunnel syndrome. Patients & Methods: We conducted a prospective, random study to evaluate the effect of epineurotomy on the outcome of operative treatment of established median-nerve compression in the carpal canal. Fifty hands (forty-four patients) were selected randomly into two groups: group I had a release of the transverse carpal ligament alone, and group II had a release and adjuvant epineurotomy of the median nerve. The groups were similar with regard to age group, gender, duration of symptoms, and preoperative physical findings. All patients had electrophysiological e
... Show MoreBackground : The hepatopulmonary syndrome (HPS) is defined as the triad of liver disease, arterial deoxygenation, and pulmonary vascular dilatation. The reported prevalence of HPS in cirrhotic patients varies between 5% -17.5%.Objective : To estimate the prevalence of hepatopulmonary syndrome among patients with chronic liver disease and portal hypertension and to study the correlation between HPS and the severity of liver disease.Patients and methods : Thirty patients were studied for the presence of HPS using transthoracic contrast echocardiography for detection of pulmonary vasodilatation. Arterial oxygen saturation (SaO2) was determined in erect and supine position using a pulse oximeter , (SaO2 ≤ 92 % in supine position and/or a d
... Show MoreObjective(s): To assess mothers' practices toward children with steroid – sensitive Nephrotic Syndrome (SSNS) who
are visiting nephrology consultation units, and to find out the relationships between their practices and the
demographical data for mother and child.
Methodology: A descriptive study was carried out at nephrology consultation units of Baghdad pediatrics hospitals
(Child's Central Pediatric Teaching Hospital, Al-kadimiyia Teaching Hospital, and Welfare Teaching Hospital) started
from February 18th to the end of July 2009. A purposive sample of (80) mothers who company their children were
selected. The data were collected through a constructed questionnaire, with two parts; the first part is concerned with<
Background: Acute coronary syndrome (ACS) is a common disease, and a major determinant of morbidity and mortality in all races. The pleiotropic effects of the receptor activator of nuclear factor-kappa B ligand (RANKL) such as modulation of cell survival, mineralization and inflammation, make it an interesting candidate mediator in the progression and destabilization of atherosclerotic lesions.Objectives: This study was performed to investigate the role of RANKL in the pathogenesis of ACS.Methods: The levels of RANKL were measured by ELISA method in sera of 60 ACS patients, 31 patients with unstable angina (UA) and 29 patients with myocardial infarction (MI) in comparison with 20 apparently healthy controls.Results: Current data indicate
... Show MoreBackground: Joubert syndrome (JS) is a very rare autosomal recessive disorder characterized by agenesis of cerebellar vermis, abnormal eye movements, respiratory irregularities, and delayed generalized motor development. Retinal dystrophy and cystic kidneys may also be associated with this clinical syndrome. The importance of recognizing JS is related to the outcome and its potential complications. This syndrome is difficult to diagnose clinically because of its variable phenotype. Its neuroimaging hallmarks include the characteristic molar tooth sign and bat wing-shaped fourth ventricle
Background: Genetic factors play an important role in susceptibility to Guillain Barre' syndrome. Human leukocyte antigen (HLA) as part of immune system has a role in the disease process.Aim of the study: to assess the relationship between HLA-A alleles with Guillain Barre' syndrome (GBS) compared with a healthy control group using PCR-SSOP method.Type of the study: Cross-sectional study.Patients and methods:Patient's group consisted of 30 Iraqi Arab Muslims patients with Guillain Barre' syndrome that consulted the Neurological department in Neurosciences Hospital between January-2013 to January- 2014 were genotyped for HLA-A alleles. A control group consisted of 30 healthy volunteers among the staff of AL-Kindi College of Medicine that
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