The aim of this work is the synthesis of new derivatives of barbiturate of D-erythroascorbic acid. To obtain these derivatives, the 5,6-O-isopropylidene-L-ascorbic acid (4) was chosen, which was prepared from the reaction of L-ascorbic acid (3) as a starting material with dry acetone in the presence of hydrogen chloride. The esterification of hydroxyl groups at C-2 and C-3 positions with excess of benzoyl chloride in dry pyridine was obtained compound (5). Hydrolysis for compound (5) in acetic acid (65%) gave the compound (6). Oxidation of the product (6) with sodium periodate results an Aldehyde (7), which was reacted with dimethyl malonate in the presence of potassium hydroxide to give the malonate (8). The cyclocondensation reaction for compound (8) with urea, thiourea and guanidine hydrochloride gave the following compounds (9), (10) and (11) respectively. All these compounds were characterised by Thin Layer Chromatography (TLC) and FTIR spectra and some were characterised by (U.V-Vis) spectra, 1HNMR spectra and 13CNMR spectra.
Mixed spinel Mg1-xZnxFe2O4 ferrites (where x = 0, 0.2, 0.4, and 0.6) nanoparticles were synthesized by using microwave-assisted combustion route. As-synthesized powdered samples were checked by XRD analysis, field emission-scanning electron microscopy, and vibration sample magnetometer to investigate the structural, morphology, and magnetic properties, respectively. XRD results exhibited that the crystallite size increases with the decrease of Zn+2 ion concentration for series of mixed spinel Mg1-xZnxFe2O4 ferrite expect x=0.2. All the mixed spinel Mg1-xZnxFe2O4 ferrite has different gr
... Show MoreEthanol as a solvent, a precursor of titanium isopropoxide and a stabilizer of either hydrochloric acid or ammonium hydroxide was used to prepare a titanium dioxide aqueous solution. The aqueous solutions with different values of pH and the morphology of the resultant reaction of the nanoparticles of titanium dioxide were investigated. The X-ray diffraction showed that at low temperatures and with acidic solutions, rutile structures are more favorable to grow on titanium dioxide synthesized, while at low and average temperatures and with base solutions, anatase phase is more pronounced. The crystalline form and the re-confirmation of the crystallite size growth were observed by the scanning electron microscopy. The atomi
... Show MoreBackground: In this study, a targeted drug delivery system has been developed based on nanoporous particles covered with cadmium sulfide and loaded with 5-flourouracil. The nanoparticles loaded drug exerts a cooperative antineoplastic activity.
Results: The development of nanoparticles loaded anticancer agent for possible application in targeted treatment of cancer where the drug release is triggered by externally applied UV irradiation. In addition, the treatment of cancer cells with drug loaded magnetic material leads to a decrease in viability of the cells due to the activity of cadmium nanoparticles. Upon exposure to low power UV light (365 nm) the loaded 5-flourouracil is released which indu
... Show MoreIncrease in unconventional resources of calcium (Ca+2) for fowls, aquaculture and native animals was improved. This work was planned to define the most polymorph of calcium carbonate (CaCO3) that take place in the two types of chicken eggshells (local and imported type). In this research, the comparative analysis of calcium carbonate (CaCO3) content was approved for nominated eggshells of native strain and imported chicken via Field Emission Scanning Electron Microscope (FESEM), Transmission Electron Microscope (TEM), Fourier-Transform Infrared Spectroscopy (FTIR) and Powder X-Ray Diffraction (PXRD) analysis. The results demonstrate that native and imported chicken eggshells comprise calcite morph that ha
... Show MoreAbstract :- In this paper, silver nanoparticles had been prepared by chemical reduction method. Many tests had been done to it such as UV-Visible spectrophotometer, XRD, AFM&SEM test. finally an attempt had been done to get the optimum condition to control the grain size of silver Nanoparticles by variation the heating period and other parameters which has an effect in silver Nanoparticles synthesis process. in this method we can get a silver nanoparticles in the size range from 52 to 97 nm.
Nitrogen-comprising heterocyclic compounds and their derivatives have empirically been invaluable as therapeutic agents. Fundamentally, 4-chloro-6-nitro-2-amino-1,3-benzothiazole 1 was synthesized via bromination of 2-chloro-4-nitro aniline with ammonium thiocyanate. This new heterocyclic haloorganoamino-1,3-benzothiazole derivative, was a starting material, which condensed and tethered with three different aromatic aldehyde pendant arm in presence of ethanol and glacial acetic acid isolating an interesting sequence of tridentate Schiff bases 2-4. These compounds were used for complexation reactions in 1:1 (metal: ligand) stoichiometry to obtain heteroleptic Al(III), Ni (II) and K(I) benzothiazole chelat
... Show MoreThe new Schiff base (L) “4‐[(2,4‐dimethoxy‐benzylidene)‐amino]‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydro‐pyrazol‐3‐one” was synthesized from 2,4‐dimethoxy‐benzaldehyde and 4‐amino‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydropyrazol‐3‐one, and the geometry of Schiff base was characterized and determined by proton nuclear magnetic resonance (1H‐NMR), mass, Fourier transform infrared (FT‐IR), and ultraviolet‐visible (UV‐vis) spectroscopy. Schiff complexes of Ni(II), Pd(II), Pt(IV), Zn(II), Cd(II), and Mg(II) have been prepared by reaction of ion metals with as‐prepared Schiff base. The results showed that synthesized complexes offered 1:2 m
1,3- Oxazepines, benz [1,2-e] [1,3]-oxazepines, and 3- nitrobenz [1,2-e] [1,3] - oxazepines were reacted with ammonia derivatives, H2N-Z .. to give 1,3 – diazepine -4,7- dione, benzodiazepine - 4,7- dione, and 3 – nitrobenzo -1,3- diazepine - 4,7- dione, respectively.
The integer simulation and development finite impulse response (FIR) filters taking into account the possibilities of their realization on digital integer platforms are considered. The problem statement and solution of multifunctional synthesis of digital FIR filters such a problem on the basis of the numerical methods of integer nonlinear mathematical programming are given. As an several examples, the problem solution of synthesis FIR-filters with short coefficient word length has been given. The analysis of their characteristics is resulted. The paper discusses issues of modeling and synthesis of digital FIR filters with provision for the possibilities of their implementation on digital platforms with integer computation arithme
... Show MoreNew nano composites containing Schiff bases have been synthesized and presented in this paper. All compounds have been categorized through FT-IR and some of them by H-NMR spectroscopy. The antibacterial performance of the prepared compounds has been investigated according to the agar diffusion method. The compounds (P1,P2,C1, and C2) have shown, in general, significant inhibition against bacterial.