Endometriosis, an autoimmune disease is among one of the most challenging of the 21 st century that affects women in reproductive age. The aim of the present study is to highlight the role of IL-36γ, and its relationship with other cytokines (Ang-2 and TNF-α) in the pathogenesis of endometriosis . Seventy five (75) consecutive women patient of reproductive age (25-40) years were enrolled in this study , Patients were divided into three groups , group 1 (G1) included (25) newly diagnosed endometriotic patients , that were not given any treatment related to Gynecology or anti-inflammatory medications . Second group : group 2 (G2) consists of (25) endometriotic patient who were treated with zoladex for 3 to 5 months , they received zoladex injection every 28 day in the first day after diagnosis. The third group: Group 3 (G3) involved (25) patients with recurrent endometriosis , they were post treatment of zoladex and diagnosis revealed recurrence of endometriosis. Patients groups were compared with two control groups , with matched age with patients’ groups. The first control group (C) included (25) healthy women , and the second control group or pathological control group (PC) involved (25) women suffering from infertility caused by gynecological disorder unrelated to endometriosis.IL-36γ , Ang-2 and TNF-α were estimated in sera of studied groups. The results from this study revealed that IL-36γ levels were highly significant increase (p<0.001) and significant increase (p<0.05) in G1 comparing with groups C and PC respectively. While high significant decrease(p<0.001) was found in G2 comparing with G1. Also , there are no significant differences (p≥0.05) shown in G2 comparing with C group and in G3 comparing with G1.On the otherhand , Ang-2 levels were highly significant increased (p<0.001) and significant increase (p<0.05) in G1 comparing with groups C and PC respectively. While significant decrease (p<0.05) was found in G2 comparing with G1. Also , there are no significant differences (p≥0.05) in Ang-2 levels shown in G2 comparing with C group and in G3 comparing with G1 Our results also implied that TNF-α levels were highly significant increased (p<0.001) in G1 comparing with C group. While no significant differences (p≥0.05) was found in G1 comparing with PC group and in G3 comparing with G1. Also there are significant differences (p<0.05) shown in G2 comparing with G1 and C group. Our findings for endometriotic patient groups. A high significant difference was found between Ang-2 and TNF-α levels with IL-36γ for G1 , G2 and G3. The conclusion of this study reveals that IL-36γ could be considered a novel biochemical marker in endometriotic patients. Conclusion could be drawn from the results that endometriosis may be influenced on the cytokines secretion such as IL-36γ beside Ang-2 and TNF-α in G1 and G3 , suggesting that inflammatory / immunological factors associating with angiogenesis responses play crucial roles in the pathogenesis of endometriosis. Also, the results showed the role of zoladex in alteration immune responses as shown in G2
The Weibull distribution is considered one of the Type-I Generalized Extreme Value (GEV) distribution, and it plays a crucial role in modeling extreme events in various fields, such as hydrology, finance, and environmental sciences. Bayesian methods play a strong, decisive role in estimating the parameters of the GEV distribution due to their ability to incorporate prior knowledge and handle small sample sizes effectively. In this research, we compare several shrinkage Bayesian estimation methods based on the squared error and the linear exponential loss functions. They were adopted and compared by the Monte Carlo simulation method. The performance of these methods is assessed based on their accuracy and computational efficiency in estimati
... Show MoreThis article presents the results of an experimental investigation of using carbon fiber–reinforced polymer sheets to enhance the behavior of reinforced concrete deep beams with large web openings in shear spans. A set of 18 specimens were fabricated and tested up to a failure to evaluate the structural performance in terms of cracking, deformation, and load-carrying capacity. All tested specimens were with 1500-mm length, 500-mm cross-sectional deep, and 150-mm wide. Parameters that studied were opening size, opening location, and the strengthening factor. Two deep beams were implemented as control specimens without opening and without strengthening. Eight deep beams were fabricated with openings but without strengthening, while
... Show MoreThere is an interesting potential for the use of GFRP-pultruded profiles in hybrid GFRP-concrete structural elements, either for new constructions or for the rehabilitation of existing structures. This paper provides experimental and numerical investigations on the flexural performance of reinforced concrete (RC) specimens composite with encased pultruded GFRP I-sections. Five simply supported composite beams were tested in this experimental program to investigate the static flexural behavior of encased GFRP beams with high-strength concrete. Besides, the effect of using shear studs to improve the composite interaction between the GFRP beam and concrete as well as the effect of web stiffeners of GFRP were explored. Encasing the GFRP
... Show MoreIn this research, the problem of multi- objective modal transport was formulated with mixed constraints to find the optimal solution. The foggy approach of the Multi-objective Transfer Model (MOTP) was applied. There are three objectives to reduce costs to the minimum cost of transportation, administrative cost and cost of the goods. The linear membership function, the Exponential membership function, and the Hyperbolic membership function. Where the proposed model was used in the General Company for the manufacture of grain to reduce the cost of transport to the minimum and to find the best plan to transfer the product according to the restrictions imposed on the model.
Objective: The study aimed to assess the postoperative nurses' intervention for the patients with laparoscopic
cholecystectomy and to determine the relationship between Nurses' interventions and their demographic
characteristics.
Methodology: Quantitative design (a descriptive study) was started from 20th November 2012 up to 1st
September 2013. Non-probability (purposive sample) of (50) nurses, who were working in surgical wards, were
selected from Baghdad teaching hospitals (Baghdad Teaching Hospital, Digestives System and Liver Teaching
Hospital, AL-Kindy Teaching Hospital, and AL-Kadhimiyia Teaching Hospita). The data were collected through
the use of a constructed questionnaire, which consisted of two parts; the
In this paper, the dynamic behaviour of the stage-structure prey-predator fractional-order derivative system is considered and discussed. In this model, the Crowley–Martin functional response describes the interaction between mature preys with a predator. e existence, uniqueness, non-negativity, and the boundedness of solutions are proved. All possible equilibrium points of this system are investigated. e sucient conditions of local stability of equilibrium points for the considered system are determined. Finally, numerical simulation results are carried out to conrm the theoretical results.
In this study, a three-dimensional finite element analysis using ANSYS 12.1 program had been employed to simulate simply supported reinforced concrete (RC) T-beams with multiple web circular openings subjected to an impact loading. Three design parameters were considered, including size, location and number of the web openings. Twelve models of simply supported RC T-beams were subjected to one point of transient (impact) loading at mid span. Beams were simulated and analysis results were obtained in terms of mid span deflection-time histories and compared with the results of the solid reference one. The maximum mid span deflection is an important index for evaluating damage levels of the RC beams subjected to impact loading. Three experi
... Show MoreInterested current Research measuring damage currency Swap by converting The ministry of higher Education and scientific Research money The Iraqi dinar To U.S dollar by Trade Bank Of Iraq , And that The damage Generated resulting from Deferent Between the Exchange Rate adopted From Central Bank of Iraq and Market Exchange Rate adopted by The Trade Bank Of Iraq , and Which led to the greet damage ( losses ) in Bearing by the ministry, which led to the reduction of the financial allocations for licensed curriculum outside of Iraq , and this in turn leads to reduction in the number of students Sender ( scholarships ) outside Iraq.
Where the estimated loss (damage) that suffer by the Ministry of H
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