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Improved oral bioavailability of lipophilic substances can be achieved using self-emulsifying drug
delivery systems. However, because the properties of self-emulsifying are greatly influenced by surfactant
amount and type, type of oil used, droplet size, charge, cosolvents, and physiological variables, the synthesis
of self-emulsifying is highly complex; consequently, only a small number of excipient self-emulsifying formulations has been developed so far for clinical use. This study reports a highly effective procedure for developing
self-emulsifying formulations using a novel approach based on the hydrophilic-lipophilic difference theory.
Microemulsion characteristics, such as the constituents and amounts of oil and surfactant electrolyte
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