DNA methylation is one of the main epigenetic mechanisms in cancer development and progression. Aberrant DNA methylation of CpG islands within promoter regions contributes to the dysregulation of various tumor suppressors and oncogenes; this leads to the appearance of malignant features, including rapid proliferation, metastasis, stemness, and drug resistance. The discovery of two important protein families, DNA methyltransferases (DNMTs) and Ten-eleven translocation (TET) dioxygenases, respectively, which are responsible for deregulated transcription of genes that play pivotal roles in tumorigenesis, led to further understanding of DNA methylation-related pathways. But how these enzymes can target specific genes in different malignancies;

Analytical Hierarchy Process (AHP) belongs to the family of Multiple Criteria Decision Making (MCDM)  and has, recently, received a wide popularity in decision making regarding supplier selection.  The objective of this study is to apply the methodology of AHP on selecting suppliers to supply materials for the  Geological Survey and Mining  Company (GSMC).  Criteria for rating the suppliers and pairwise comparisons were identified by the members of the Tenders Analysis Committee (TAC). In order to judge the internal validity of the AHP, it was applied manually on a sample of fourteen tenders that were analyzed  and executed between 2004-2007, then an interactive computerized  package was developed 

The research aims to diagnose the level of reflection of uncertainty management strategies (Ignoring uncertainty, knowledge generation , interaction , coping) managing of Organizational change strategies (power coercive, rational empirical, Normative reductive) to the importance of the two subjects and the importance of the expected results has been selected sample size (65) managers from Zain , Asia Cell Telecommunication (32 Zain and 33 company Asia),which alignment for the such a study being heavily dependent on the certainty or uncertainty subject . The researchers are attain there is the effect of uncertainty management strategies in Organizational change management strategies on the overall level in the two companies but have tended t

Cost is the essence of any production process for it is one of the requirements for the continuity of activities so as to increase the profitability of the economic unit and to support the competitive situation in the market. Therefore, there should be an overall control to reduce the cost without compromising the product quality; to achieve this, the management should have detailed credible and reliable information about the cost to be measured, collected, understood and to analyze the causes for the spread of deviations and obstacles the management faces, and to search for the factors that trigger the emergence of these deviations and obstacles

يتمثل الهدف الأساس للبحث بالتعرف على دور عناصر المزيج التسويقي (المنتج، السعر، الترويج، التوزيع، العاملون، الدليل المادي، العملية) في تعزيز ولاء الزبون (الولاء السلوكي، الولاء الموقفي، الولاء الادراكي)، ولغرض تحقيق الهدف اعتمد الباحث المنهج الوصفي التحليلي لتحليل فرضيات الارتباط والتأثير للبحث، تم جمع المعلومات من خلال الاستبانة التي عدت لهذا الغرض، وجرى استطلاع آراء (300) زبون من زبائن الأسواق، واستعم

    ان الهدف من البحث الحالي هو للتعرف على أهمية دور تخطيط التعاقب الوظيفي في تنمية رأس المال البشري في المنظمات في ظل الاحداث والمتغيرات المتسارعة والديناميكية في بيئة العمل ، وقد اشارت مشكلة البحث إلى خطورة تقاعد أو مغادرة الموظفين لمناصبهم لأي سبب كان ومدى تأثيره على المنظمة في خلق فجوات في القيادة ومشاكل في إدارة ضخ المواهب ، لأنه سيحدث نقص في المواهب ، الأمر الذي سيؤثر بدوره على الأداء العام للأعمال

The Iraqi non profit governmental units are facing great financing challenges in providing the money required for reconstructing the damages occurred after 9^th of April 2003.

Related to that, This research, which is contained of studying the self – financing experiment in non profit governmental units which is considered one of the financing alternatives that contribute in providing the required money to meet the shortage of central finance; and creating the economic exploitation for the resources and possibilities achieved by the non profit governmental units themselves for the purpose of employ them in reconstruction and to reduce the burden on the public budget which is responsible of fin

Pollution of the aquatic environment and the depletion of the natural resource cause imbalance in the natural balance of the river environment and contributes to the deterioration of life and the killing of living organisms. Most of the old and modern cities and urban centers were set up close to the rivers because water enters the main lifeblood and all its facilities. The proximity of cities to rivers caused environmental problems resulting from the dumping of residues of these cities to a large and continuous, these wastes include all uses of the city (industrial, agricultural, residential and commercial) and others. The accumulation of these wastes inside the rivers water kills life and makes them unsuitable for various uses to bury

السخرية والمفارقة في شعر احمد مطر

فن الزخرفة في حياة وادي الرافدين