Background: This study was conducted to evaluate the hard palate bone density and thickness during 3rd and 4th decades and their relationships with body mass index (BMI) and compositions, to allow more accurate mini-implant placement. Materials and method: Computed tomographic (CT) images were obtained for 60 patients (30 males and 30 females) with age range 20-39 years. The hard palate bone density and thickness were measured at 20 sites at the intersection of five anterioposterior and four mediolateral reference lines with 6 and 3 mm intervals from incisive foramen and mid-palatal suture respectively. Diagnostic scale operates according to the bioelectric impedance analysis principle was used to measure body weight; percentages of body fat, water, and muscle; bone mass; and basal and active metabolic rates. Results: No significant difference in overall bone density and thickness of hard palate during 3rd and 4th decades. The gender should be considered in regard to bone thickness. Cortical bone density and thickness showed a tendency to decrease posteriorly, while the cancellous bone density showed a tendency to increase posteriorly. In the mediolateral areas, no specific patterns were observed. With increasing BMI, the cortical bone density was increased. The relationships of bone density and thickness with most scale measurements were not significant. Conclusion: Mini-implants for orthodontic anchorage can be effectively placed in most areas of hard palate regarding the bone density. While regarding bone thickness, care should be taken during the planning of their placement in hard palate. A new classification for bone thickness of hard palate has been developed.