Background: The repair of bone defects remains a major clinical orthopaedic challenge. Bone is a highly vascularised tissue reliant on the close spatial and temporal connection between blood vessels and bone cells to maintain skeletal integrity. Angiogenesis thus plays a pivotal role in skeletal development and bone fracture repair. The role of angiogenic and osteogenic factors in the adaptive response and interaction of osteoblasts and endothelial cells during the multi step process of bone development and repair will be highlighted in this study. This study aimed to identify the role of local exogenous vascular endothelial growth factor in bone healing and to analyze the expression of VEGF by immunohistochemistry in created bone defect after application with different biomaterials in a rat model. Materials and methods: In this experimental study eighteen male Albino rats, weighing (300-400) gram, aged (6-8) months were used and maintained under control conditions of temperature, drinking and food consumption. The animals were subjected for a surgical operation of medial sides of both tibiae bone ( right side was considered as experimental site ,while left be the control one), in control group the bone defect treated with local application of 1µm of normal saline, while experimental treated with local application of 1µm of VEGF .The rats were sacrificed at 3,7,10 days after surgery(six rats for each period). Bone healing was histologically examined with immunohistochemical localization of VEGF Results: Bone defect treated with local application of VEGF shows an early osteoid tissue deposition with high cell count for osteoblast, osteocyte and osteoclast. Immunohistochemical evaluation for VEGF by stromal cells, reported to be higher with significant difference in VEGF group in comparison to control. Conclusion: The study illustrated that low application of VEGF could be an effective therapeutic expression for bone injuries; these data are promising for a possible future clinical usage.
Manganese is considered as one of heavy metals with high toxicity .This element has been used widely in various industries and it is spread with huge quantities in polluted industries areas. As a result the concentrations of this element in the environment have increased and consequently producing acute toxic effects in different tissues and organs of all organisms. A study has been conducted on (30) female of Swiss albino mice, to find out the effect of manganese chloride in histopathological changes of ovaries. The study includes, giving the manganese chloride with concentrations (150, 200 and 250 mg/kg) for (15, 30 and 45 day) for each concentration. The
... Show MoreThe objectives of this paper was the development of a novel ligand, L, which was achieved in two stages: ligand is synthesised by reducing the result of the reaction between cyclohexane-1,2-diamine and 4-hydroxy-3,5-dimethoxycy clohexane-1-carbaldehyde, followed by the production of the 4,4’-((1E,1’E)-(1,2 phenylenebis(azanylylidene))bis(methanylylidene))bis(2,6-dimethoxyphenol) precursor (P). While studying corrosion inhibition (copper alloy) in acid solution by weight loss, compounds were characterised using 1H, 13CNMR (for ligand (L) and (P)), FT-IR and UV spectra, melting point, molar conductivity, %C, %H and %N, %M, and magnetic susceptibility. The complex’s octahedral structure is inferred from the bidentate coordination
... Show MoreThe results of this study showed that the tongue of the adult Iraqi domestic cat is divided into three regions of apex, body and root. The dorsal surface of all regions possesses five types of lingual papillae, two mechanical which are filiform and cylindrical papillae, while the other three types are taste papillae which are foliate, fungiform and circumvallate papillae, while these papillae are absent on its ventral surface. The histological examination of all tongue areas revealed that it consisted of three tunica, the tunica mucosa and the tunica submucosa (the lamina propria) and the tunica muscularis. The tunica mucosa consisted of the epithelial lining, which is a stratified squamous epithelial tissue covering the lingual papillae, a
... Show MoreOne of the challenging issues encountered during drilling operations is the lost circulation. Numerous issues might arise because of losses, such as wasting of time and higher drilling cost. Several types of lost circulation materials have been developed and are being used to limit mud losses and avoid associated issues. Each solution has benefits and drawbacks.
In this study, a core flooding test was performed to study the effectiveness of polyacrylamide (PAM) granular gel on the reduction of the circulation lost. One common type of fracture characteristic is fractures with tips, commonly known as partially open fracture (POF). However, PAM gel therapy in POFs received little attention in prior research. Models of partly open fra
... Show MoreObjective: This project aimed to study the morphological description and histological structure of ileum in Iraqi black partridge (
The present study aims to investigate the long-term histopathological, and physiological effects of different concentrations of a commercially available energy drink (Tiger) on liver and kidney of young mice. Sixteen Balb/c male mice,6 -week old, were divided into 4 groups (n=4). Two groups consumed the energy drink at a concentration of 28µl energy drink/ml water. One group were killed after 10 days (T1), another group were killed after 20 days (T2). Other group of mice consumed the energy drink at a final concentration of 14µl/ml for 20 days (T3). The last group was provided only with water and served as control. Mice of all groups drank around 3 ml per day. The histopathological study on liver of treated groups showed many changes s
... Show MoreThe aim of this study to investigate the tongue morphology and histology in house gecko Hemidactylus flaviviridis using light and scanning electron –microscopy (SEM ) technique.The morphology result revealed the presence of three parts : apex , body and lingual root .The light microscopy result showed that the tongue is covered with mucous membrane composed of non keratinized stratified squamous epithelium based on lamina propria which contain bundles of striated muscles its fibers in different directions including connective tissue , blood vessels and nerves. The lingual mucosa of the dorsal surface is covered with different pattern of lingual papillae which are widely distributed all over the dorsal surface except the apex. Noticed on t
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