Background: It has been well known that the success of mandibular implant- retained overdenture heavily depends on initial stability, retention and long term osseointegration this is might be due to optimal stresses distribution in surrounding bones. Types of mandibular implant- retained overdenture anchorage system and number of dental implants play an important role in stresses distribution at the implant-bone interface. It is necessary to keep the stresses below the physiologic tolerance level of the bone .since. And it is difficult to measure these stresses around bone in vivo. In the present study, finite element analysis used to study the stresses distribution around dental implant supporting Mandible implant retained overdenture Materials and methods: Eight models were constructed including four designs of anchorage system (ball-cup, ball-O Ring, bar without distal extension and bar with distal extension).The first group of models were supported by four dental implant and second group of models were supported by two dental implant only. Models constructed from the data obtained directly from patient The contour of bone was obtained from C.T scan image of patient, then data transferred to ANSYS program for modeling then load applied and solve the equation by the program, Specified nodes were selected at the rings of crestal bone (cortical bone) and cortical cancellous interface around each dental implant and fixed for all models to monitor the stress change in that regions of different design of MIR-OD.. After load application, Specified nodes were selected at the rings of crestal bone (cortical bone) and cortical cancellous interface around each dental implant and fixed for all models to monitor the stress change in that regions of different design of MIR-OD . Results: In the present study the stress distribution and maximum stresses value around dental implant had a relationship to the number of dental implant. , The result appeared that the maximum stresses and means of stresses value was lower in the first group of models (which was supported through the use four dental implant) than the second group of models (which was supported through the use of two dental implant only). For the first group of models the maximum stresses value around mesial implant was11.67, 10.51, 10.98 and 10.72 Mpa, while the maximum stresses around distal implant was 21.33, 18.51, 18.86, and17.56 Mpa for models 1,2,3 and 4respectively ,and the stresses around implant supporting second group of models was 22.52, 22.16, 20.51 and 19.60 Mpa for models 5,6,7and8 respectively .Statistical analyses of means value appeared that there was statistically significant difference in stresses means value around implant of the second group with that’s values around mesial and distal implant supporting first group of model . Regarding the result of both ball and bar system, it has been demonstrated that stress was greater with ball attachment and MIR-OD supported by the use of four dental implants and anchored by bar attachments with distal extension gives the minimum values of stresses than the rest models. Also the results show that higher stresses value was appeared at the cortical bone ring surrounding dental implant especially the distal implant nearest to the free end extension area. Also it was appeared that the best model was Mandible implant- retained overdenture that’s anchored by bar with distal extension and support by four dental implant. Conclusions: Bar-clips with distal extension mode of attachment considered the best type in producing the least stresses around dental implant regardless number of dental implant used.
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Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and synthesis of a potent pan-inhibitor for PRMTs that tethers a thioadenosine and various substituted guanidino groups through a propyl linker. Compound II757 exhibits a half-maximal inhibition concentration (IC50) value of 5 to 555 nM for eight tested PRMTs, with the highest inhibition for PRMT4 (IC50 = 5 nM). The kinetic study demonstrated that II757 competitively binds at the SAM binding site of PRMT1. Notably, II757 is selective for PRMTs over a panel of other methyltransferases, w
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Due to the development that occurs in the technologies of information system many techniques was introduced and played important role in the connection between machines and peoples through internet, also it used to control and monitor of machines, these technologies called cloud computing and Internet of Things. With the replacement of computing resources with manufacturing resources cloud computing named converted into cloud manufacturing.
In this research cloud computing was used in the field of manufacturing to automate the process of selecting G-Code that Computer Numerical Control machine work it, this process was applied by the using of this machine with Radio Frequency Identification and a AWS Cloud services and some of py
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This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low and an erratic bioavailability range from 13%-17%. The domperidone nanoparticles were prepared by solvent/antisolvent precipitation method at different polymer:drug ratios of 1:1 and 2:1 using different polymers and grades of poly vinyl pyrolidone, hydroxy propyl methyl cellulose and sodium carboxymethyl cellulose as stabilizers. The effect of polymer type, ratio of polymer:drug, solvent:antisolvent ratio, stirring rate and stirring time on the particle size, were investigated and found to have a significant (p? 0.05) effect on particle size. The best formul
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The evaluation of subsurface formations as applied to oil well drilling started around 50 years ago. Generally, the curent review articule includes all methods for coring, logging, testing, and sampling. Also the methods for deciphering logs and laboratory tests that are relevant to assessing formations beneath the surface, including a look at the fluids they contain are discussed. Casing is occasionally set in order to more precisely evaluate the formations; as a result, this procedure is also taken into account while evaluating the formations. The petrophysics of reservoir rocks is the branch of science interested in studying chemical and physical properties of permeable media and the components of reservoir rocks which are associated
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Construction is a complicated process that takes place in an almost uncontrollable environment. Although projects can be carefully planned in advance in principle, there is a chance that unforeseen events and crises can disrupt these plans, affecting project development. Because the initial investment expenditures in construction projects are so large, they may be quickly influenced by crises, resulting in significant financial losses. The 2014 financial crisis was one of the most prominent crises that Iraq faced, which significantly impacted various activities in general and the construction industry in particular. Despite the importance of crisis management systems, the researchers found a great lack of local studies l
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Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is used in the treatment of hypertension, angina pectoris, in addition to Parkinson disease. It goes under the BCS class II drug (low solubility-high permeability). The drug will experience extensive first-pass metabolism in liver, therefore, oral bio-availability will be approximately15 to 24 %.
The aim of this study was to formulate and optimize a stable nanoparticles of a highly hydrophobic drug, isradipine by anti-solvent microprecipitation Method to achieve the higher in vitro dissolution rate, so that it will be absorbed by intestinal lymphatic transport in order to avoid hepatic first-pass metabolism&nbs
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Poorly soluble drugs are often a challenge in product formulation. Generally, low aqueous solubility and poor bioavailability of drugs have restricted their application in various fields. Nanosuspensions enhance the solubility and bioavailability of poorly water-soluble drugs. Curcumin, a hydrophobic polyphenol, exhibits poor aqueous solubility (<1 μg/mL), and formulating it as nanosuspension can enhance its solubility. However, the optimal selection of preparation technique, solvent, stabilizer, and drug-to-stabilizer ratio is critical for formulation success for a successful formulation. This work aims to optimize the preparation process of Curcumin nanosuspension. In addition, it aims in screening of the effectiveness of different stabi
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