Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining
susceptibility to MS. The exact effect of the former is intended for investigation in our study.
Objectives: The objective of the study is to compare the demographic features, clinical presenting features, and clinical course between familial and sporadic cases of MS.
Materials and Methods: this is a retrospective cohort study conducted in Multiple Sclerosis Center in the Medical City in Baghdad. The records of the MS center in Baghdad Teaching Hospital were surveyed, and data from 13 patients with positive family history of MS, and 13 patients with out family history of MS
was analyzed.
Results: Regarding the clinical presentation, for those with family history of MS the common presenting symptoms were sensory symptoms and transverse myelitis, and those without family history of MS was pyramidal, for those with family history of MS 11 patients had initial course of relapsing remitting MS ( 84.6%) ,of them 4 patients progressed into secondary progressive MS (36.4%); 2 patients had primary progressive MS as initial course, for those with negative family history of MS 12 patients had initial course of relapsing remitting MS, of them 5 patients progressed into Secondary progressive MS (41.6%); 1 patients had primary progressive MS as initial course (7.7 %.). No significant difference was found in
the investigated parameters, except for the inverse relation between age of onset and lag time to diagnosis.
Conclusion: Familial MS do not significantly differ from sporadic MS in terms of the demographic patterns and clinical course and presentation. This is not the case for the relationship between the age of disease onset and lag time to diagnosis.
Acute lymphoblastic leukemia (ALL) is a cancer of the blood and bone marrow (spongy tissue in the center of bone). In ALL, too many bone marrow stem cells develop into a type of white blood cell called lymphocytes. These abnormal lymphocytes are not able to fight infection very well. The aim of this study was to investigate possible links between E3 SUMO-Protein Ligase NSE2 [NSMCE2] and increase DNA damage in the childhood patients with Acute lymphoblastic leukemia (ALL). Laboratory investigations including hemoglobin(Hb) ,white blood cell (WBC) , serum total protein , albumin ,globulin , in addition to serum total antioxidant activity (TAA) , Advanced oxidation protein products(AOPP) and E3 SUMO-Protein Ligase NSE2[NSMCE2]. Blood samples
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The purpose of our study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DE-NLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral absorption of low bioavailability drug, different Oleic acid ratios effect on particle size, zeta potential, entrapment efficiency and loading capacity were studied, the optimized DE-NLCs shows a particle size within the nanorange, the zeta potential (ZP) was 33.81±0.73mV with drug entrapment efficiency (EE%) of 92.42±2.31% and a loading capacity (DL%) of 7.69±0.17%. about 92% of drug was released in 24hr in a controlled manner, the ex-vivo intestinal p
... Show MoreActivated carbon prepared from date stones by chemical activation with ferric chloride (FAC) was used an adsorbent to remove phenolic compounds such as phenol (Ph) and p-nitro phenol (PNPh) from aqueous solutions. The influence of process variables represented by solution pH value (2-12), adsorbent to adsorbate weight ratio (0.2-1.8), and contact time (30-150 min) on removal percentage and adsorbed amount of Ph and PNPh onto FAC was studied. For PNPh adsorption,( 97.43 %) maximum removal percentage and (48.71 mg/g) adsorbed amount was achieved at (5) solution pH,( 1) adsorbent to adsorbate weight ratio, and (90 min) contact time. While for Ph adsorption, at (4) solution pH, (1.4) absorbent to adsorbate weight ratio, and (120 min) contact
... Show MoreThe research studied and analyzed the hybrid parallel-series systems of asymmetrical components by applying different experiments of simulations used to estimate the reliability function of those systems through the use of the maximum likelihood method as well as the Bayes standard method via both symmetrical and asymmetrical loss functions following Rayleigh distribution and Informative Prior distribution. The simulation experiments included different sizes of samples and default parameters which were then compared with one another depending on Square Error averages. Following that was the application of Bayes standard method by the Entropy Loss function that proved successful throughout the experimental side in finding the reliability fun
... Show MoreBackground: Suppression of quorum sensing (QS) that regulates many virulence factors, including antimicrobial resistance, in bacteria may subject the pathogenic microbes to the harmful consequences of the antibiotics, increasing their susceptibility to such drugs. Aim: The current study aimed to make an aqueous crude extract from the soil Proteus mirabilis isolate with the use of the gas chromatography-mass spectrometry (GC-MS) technique for its analysis, and then, study the impact of the extract on clinical isolates of Pseudomonas aeruginosa. Methods: Preparation of crude extracts from P. mirabilis (both organic and aqueous), which were then analyzed by GC-MS to detect the bioactive ingredients. Furthermore, the extract’s capability to i
... Show MoreA large number of natural or synthetic dyes have been removed from both national and international lists of permitted food colors because of their mutagenic or carcinogenic activity. Therefore, this study aimed to use the Random Amplified Polymorphic DNA-Based Polymerase Chain Reaction (RAPD-PCR) assay as a feasible method to evaluate the ability of some food colors as genotoxin-induced DNA damage and mutations. Lactiplantibacillus plantarum was used as a bioindicator to determine the genotoxic effects by RAPD-PCR using M13 primer after treatment with some synthetic dyes currently used as food color additives, including Sunset Yellow, Carmoisine, and Tartrazine. Besides qualitative analysis, the bioinformatic GelJ software was used for clus
... Show MoreJordan curve theorem is one of the classical theorems of mathematics, it states the following : If is a graph of a simple closed curve in the complex plane the complement of is the union of two regions, being the common boundary of the two regions. One of the region is bounded and the other is unbounded. We introduced in this paper one of Jordan's theorem generalizations. A new type of space is discussed with some properties and new examples. This new space called Contractible -space.