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The Relationship between Family History and C-peptide Level in Type2 Diabetic Patients

Background: Family history of type 2 diabetes is a major risk factor for type 2 diabetes. Type 2 diabetes is characterized by progressive β-cell dysfunction; many investigators have used C peptide levels as a biomarker of β-cell function.

Objective: the current study was design to investigate the impact of family history on biochemical characteristics (c-peptide, HbA1c, lipid profile, insulin secretion, insulin sensitivity and insulin resistance.

J Fac Med Baghdad

2013; Vol.55, No .3

Received Feb .2013

Accepted July.2013

Subjects and methods: three hundreds patients (152 males 148 females) with type 2 DM were enrolled in this study; and two hundreds individual serves as a control groups (103 male 97 female). The following clinical characteristics were reported: age, sex, waist circumference WC, systolic blood pressure SBP, diastolic blood pressure DBP, family history, body mass index BMI, laboratory analyses included serum c-peptide, blood glycosylated hemoglobin (HbA1c) assay, lipid profile which included serum cholesterol, serum triglyceride(TG), serum low density lipoprotein cholesterol (LDL) and serum high density lipoprotein-cholesterol (HDL). Insulin secretion, sensitivity and resistance were calculated from fasting serum glucose (FSG) (mg/dl) and C-peptide (ng/ml) values by homeostasis model assessment (HOMA).The statistical analysis was done by SPSS (statistical packagefor social sciences- version 17).

Result: Statistically was observed that highly significant increase in serum C-peptide in patients compared to control group (3.85±1.02 vs 1.53±0.24 p<0.01).The patients with a family history of type 2 diabetes mellitus had longer diabetes duration, heavier weight, higher levels of TG, LDL-cholesterol, and lowered age, HDL-cholesterol than those without a family history . Also, the presence of a family history of diabetes was associated with lower levels of fasting plasma C-peptide (3.01± 1.78 vs 4.95±1.82, p<0.05). Serum C-peptide had a significant negative correlation with family history and duration of diabetes. Furthermore, C-peptide was inversely correlated with HbA1c, and insulin sensitivity (HOMA-S). On the other hand, C-peptide correlated positively with BMI, DBP, LDL-cholesterol, TG, insulin resistance HOMA-IR, and insulin secretion HOMA-B. As well as, C-peptide did not show significant correlation with age, FSG, and TC. When the multiple linear analysis was executed with C-peptide as dependent variable with other independent variable (BMI, duration, family history, HOMA-IR, HOMA-S, and HOMA-B) there were significant result with this variables. The person correlation analyses to identify the parameters that most closely related with diabetic duration according to family history of diabetes; which showed that diabetic duration had a significant negative correlation with C-peptide, and HOMA-B only in patients with family history of Type2 DM (-0.126, and -0.229) respectively.

Conclusion: the current study suggested that subjects with a family history of diabetes mellitus are predisposed to develop this disease earlier. Although, serum C-peptide increased significantly in diabetics group compared with controls, and C-peptide decreased in patients with family history of diabetes. In addition, the results showed that family history of type2 diabetic patients is thought to have a deep impact on duration of the disease, lipid profile, insulin resistance, insulin sensitivity, and this may lead to higher prevalence of diabetic complication compared to patients without family history. These results support the necessity of earlier screening for diabetes in family members of T2DM patients and prevention the complications of the disease.

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Publication Date
Thu Dec 29 2016
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Comparison in Some Biochemical and Hematological Tests Between Chronic Hepatitis B and C

  Chronic viral hepatitis is an important health problem in the world, where hepatitis B virus (HBV) or hepatitis C virus (HCV) infections are the main causes of liver insufficiency. The study included 100 blood samples from patients with chronic viral hepatitis, fifty of them with HBV infection and 50 with HCV infection. Twenty apparently healthy age and gender matched subjects were included as a control group. Out of the 50 patients with HBV, 36(72%) were males and 14(28%) were females. Thirty two (64%) patients with HCV were males and 18(36%) were females. The mean age for HBV patients was 36.9 ± 15.8 year and for HCV patients it was 39.9 ±14.2 year.  The results of the liver function tests showed no significant differ

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Publication Date
Mon Jan 01 2024
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Association between Body Mass Index and Depressive Symptoms among Adolescent Females in Baghdad, AlKarkh during 2022

Background: Due to their high prevalence rates, adolescent obesity and depression are among the most renowned public health concerns globally.  Obesity is considered the leading cause of morbidity and death in Iraq in 2019.  There is scarce research and surveys regarding the relationship between BMI and depression, especially in young Iraqi females.

Objectives: To explore the level of depression among adolescent girls, and to determine its association with Body Mass Index in the studies group.

Methods: Beck’s depression inventory questionnaire was used in 11 high schools for girls that were selected randomly from the schools in Baghdad/ AlKarkh from 1st of January 2023

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Publication Date
Mon Oct 17 2022
Journal Name
Journal Of The Faculty Of Medicine Baghdad
A Comparative Study of Serum Amyloid A2 with Anti-cyclic Citrullinated Peptide antibody in the prognosis of a Group of Rheumatoid Arthritis Patients in Iraq

Background: Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology characterized by joint inflammation and the presence of autoantibodies, mostly Anti-cyclic citrullinated peptide antibody (ACCP) which are released when the body loses its ability to distinguish between self and foreign molecules. Serum amyloid A2 (SAA2) is an acute phase protein produced in response to inflammatory conditions including RA.

Objectives: To investigate the prognostic ability of SAA2 in comparison with ACCP and the prediction of disease activity and response to treatment by Methotrexate and Etanercept in Iraqi RA patients.  

Patients and methods: A case control study, on a to

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Publication Date
Tue Jan 02 2018
Journal Name
Journal Of Educational And Psychological Researches
Psychological social conflict and its relation with family parental style for adolescences from the intermediate stage student at governmental Hail school, in the light of economical levels and sex variables .KSA

The current research attempts to examine the relationship between social-psychological conflict and their relation to family upbringing approaches among the adolescents of intermediate stage according to sex and economical level. To do this, the researcher prepared a questionnaire to measure social-psychological conflict that consisted of (32) item divided on four dimensions, and also she prepared a questionnaire to measure family upbringing approaches which composed of (28) item divided on four dimensions. The sample was (260) male and female student from intermediate stage chosen randomly. The results revealed that there were significant differences between social-psychological conflict which went to male, there was a negative correlat

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Publication Date
Mon Feb 28 2022
Journal Name
Journal Of Educational And Psychological Researches
Goal Conflict among Twelfth-Grade Students based on Gender and Major

The aim of the current study is to identify the level of goal conflict with twelfth-grade students in South Sharqiah/ Sultanate of Oman according to gender and specialization. The study used the descriptive method. A scale of (28) items was developed and divided into six dimensions: time pressure, goal achievement, limit of power, limit of budget, incompatible strategies, and unclear task. To validate the scale, it was piloted (40) students. The scale was administered to a sample of (402) students (209) males in the Governorate of South Sharqiah. The results showed that the conflict level was high in “unclear task”, and an average conflict level in “limit of power”. Other dimensions (goal achievement, time pressure, limit of powe

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Publication Date
Thu Jan 31 2019
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
Analysis the Expected Profit By the Relation Between the Sustainable growth and Actual growth: Apply Study for Iraq Stock Exchange

The research aims to analysis the future profits of companies listed on the Iraq Stock Exchange through analyzing the relationship between Actual Growth and Sustainable Growth, The study was applied to the sample of companies included in the Iraq Stock Exchange for the period (2010- 2014), The Internal Growth Rate has been used as a measure for the Actual Return Rate but the Sustainable Growth Rate has been measured under the Rose model, The research showed group of conclusions, the most important are:1. From the analysis of sustainable growth for the banks sample and the variables involved in its measure shows that investment in the investors amounts have achieved a significant return, which demonstrates the company's efficiency at gene

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Publication Date
Sun Mar 06 2016
Journal Name
Baghdad Science Journal
Association of Glutathione–S-Transferase (GSTP1) Genetic Polymorphism in Iraqi Patients with Diabetes Mellitus Type2

Glutathione S-transferases (GSTs) are enzymes that included, in a more range of detoxifying reactions by conjugation of glutathione, to electrophilic material. Polymorphisms n the genes that responsible of GSTs affect, the function of the GSTs. GSTs play an active role in protection of cell against oxidative stress mechanism. Polymorphisms of GSTP1 at codon 105 amino acids forms GSTP1 important site for bind of hydrophobic electrophiles and the substitution of Ile/Val affect substrate specially catalytic activity of the enzyme and may correlate with reach to different diseases in human like diabetes mellitus type2 disease. Correlation between these polymorphisms and changes in the parameters file of diabetic patients has also bee

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Publication Date
Sun Oct 02 2016
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Molecular Classification of Iraqi Breast Cancer Patients and Its Correlation with Patients’ Profile

Background: Breast cancer is a complex, multifaceted disease encompassing a great variety of entities that show considerable variation in clinical, morphological and molecular attributes.
Objective: The aim of this study to evaluate patients’ molecular profile (Estrogen receptor, Progesterone receptor, HER2/neu and Ki-67).
Patients & Methods: This is a cross-sectional descriptive study was done in Baghdad oncology teaching hospital from December 2015 to April 2016, carried on 100 breast cancer female patients with their age range from 27 to 73 years old and with their histopathology reports and (IHC) results.
Results: The highest incidence of breast cancer among patients in 5th (40-49 years) and 6th (50-59 years) decades o

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Publication Date
Sun Aug 13 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Evaluation of Fucose Level and Other Parameters in Sera of Diabetic ( type II )

This research included clinical biochemical study of some important biochemical variations of diabetes patients of type II ( NIDDM ) in comparison with the normal serum of healthy persons (control group ) , aiming to explain the relation between these variations .       The following tests were done :FBS,HbA1cTF, LAF Lipid profiles ,Cu, Zn , and Cu/Zn ratio.                   The results have been constructed by studying  the values of the  relation between the variations . The relation between TF, LAF, FBS, HbA1c, Cu and CU/ Zn ratio is positive , while the relation between the above mentioned variations and

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Publication Date
Wed Feb 08 2023
Journal Name
Iraqi Journal Of Science
The Relationship between Celiac Disease and Unexplained Infertility

To determine the relationship between celiac disease and reproductive complication, twenty five women with clinically definite unexplained infertility aged (22-35) have been investigated and compared to fifteen apparently healthy women. All the studied groups were subjected to measurement of anti-tissue transglutaminase antibodies IgA and IgG by ELISA technique and anti-endomysial antibodies IgA and IgG by IFAT technique .There was a highly significant elevation (P< 0.01) in the concentration of anti- tTG IgA Abs compared to control group, Also, there was significant elevation (P< 0.05) in the concentration of anti- tTG IgG Abs compared to control group .The results illustrated that the prevalence of anti-EMA IgA and IgG Abs were (

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