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iqjmc-502
Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human colorectal Carcinoma (Clinicopathological study)
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Background: Colorectal adenocarcinoma is the most common type of gastrointestinal cancer, with about 150,000 cases each year in the United States and about 56,730 deaths from colorectal cancer risk. In Iraq and according to the Iraqi cancer registry (ICR) reports, the incidence of colorectal carcinoma was 4.55% of whole body malignancy, & it is the seventh cause of death from cancer (ICR 2005). In males, it’s the 7th common cancer while in females it’s the 4th most common cancer. The estrogen and progesterone receptors belong to a super- family of nuclear hormone receptors. These receptor proteins function as transcription factors when they are bound to their respective ligands, these receptors shares a common structural and functional organization

Objectives: to evaluate the immunohistochemical expression of estrogen (ER) and progesterone (PR) in colorectal adenocarcinoma and to correlate this expression with different clinical and pathological parameters.

Material and method: Twenty five cases of colorectal adenocarcinoma diagnosed in private laboratories in Baghdad/Iraq from November 2011 to march 2013, were respectively evaluated in term of age, gender, pathological diagnosis, including the tumor site, size, lymph nodes status, grade and stage of tumor. Using infiltrative ductal carcinoma of the breast as control for both estrogen and progesterone receptors expression were investigated immunohistochemically, nuclear and cytoplasmic staining of tumor cells were accepted positive.

Results: Fourteen (56%) of the cases were male, 11 (44%) case were female, with age distribution ranging from (24-84) years, with a mean age of 56.5 year. Tumor size ranges between 2.5-10 cm, mean of 6.25 cm. Seven cases (28%) cases were from the caecum, 5(20%) from each rectum, sigmoid and left colon respectively and 3(12%) cases were from more than one segment of the colon. Histologically the tumor grade ranges from moderately differentiated in 23(92%) cases and poorly differentiated in 2(8%) cases. Regarding pathological staging (TNM system), 5(20%) cases were stage T2, 17 (68%) cases were stage T3 and 3(12%) cases were T4, lymph node involvement found in 10(40%)  cases and distant metastasis were found in 2 (12%) cases. Estrogen receptors expression was positive in 2(8%) cases, while progesterone receptor was positive in 5(20%) cases; both ER positive cases were PR positive. Both ER positive cases were female; one of the PR positive cases was male. All of the ER and PR positive cases were moderately differentiated, one case of ER positive tumor showed nodal involvement while three cases of PR positive showed nodal involvement.      

Conclusion: - Estrogen and progesterone receptors in colorectal adenocarcinoma had same activity. The level of ER and PR expression in tumor tissue could not predict malignant biological behavior of the colorectal adenocarcinoma. No significant statistical correlation was observed between ER, PR expression and any of the studied clincopathological parameters.

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Publication Date
Thu Dec 26 2024
Journal Name
Mustansiria Dental Journal
Bite force in Iraqi children in relation to teeth contact and mandibular incisors angulation
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Publication Date
Tue Oct 17 2023
Journal Name
The Scientific World Journal
Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry
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Phytomedicine refers to the use of naturally derived products to cure and mitigate human conditions. Natural products have the advantages of causing minimum side effects, being biocompatible, available, and economical, with a wide array of biological activities. Reports have described the use of natural products with antimicrobial and anti-inflammatory properties to treat oral conditions and promote wound healing. Moringa oleifera, known as the “drumstick” or “horseradish” tree, is believed to have medicinal properties regarding a range of medical conditions, though there is limited information on its use in oral medicine. This narrative review focuses on the use of Moringa extracts in the management of oral conditions, incl

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Publication Date
Sat Jan 07 2023
Journal Name
Journal Of Advanced Pharmacy Education And Research
Fimasartan attenuates edema and systemic changes in egg albumin-induced paw inflammation in rats
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Angiotensin receptor blockers are well known for their therapeutic efficacy and fimasartan has been used safely and efficiently since 2010 in the treatment of hypertension. The study aimed to examine the anti-inflammatory effect of fimasartan in egg albumin-induced inflammation in rats. Rats were treated with diclofenac (25 mg/kg, intraperitoneally) or fimasartan at two different doses (3 or 10 mg/kg, intraperitoneally). The increase in the thickness of the paw was considered to be edema, which was measured using a vernier caliper. Serum was collected to analyze the systemic production of the inflammatory mediators TNF-α, and IL-6. The results showed that fimasartan in both doses significantly reduced edema in inflamed rat paws and produce

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Publication Date
Fri Dec 30 2011
Journal Name
Al-kindy College Medical Journal
Causative Organisms and Risk Factors In Bacterial Meningitis in Al-Elwia Childhood Hospital - Baghdad
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Background: Childhood meningitis is a major
cause of morbidity and mortality, Hemophilus
influenza b (Hib) is the most common cause in
many countries, especially below 5 years and
before the development of conjugated Hib vaccine,
it is followed by Streptococcus Pneumonia, and
then N. meningitides, in addition to other
microorganisms.
Objective: To identify the causative organisms
of bacterial meningitis and to identify the factors
predisposing significantly to the incidence of
bacterial meningitis.
Method: This cross sectional , study was done in
Al-Elwia Pediatric Hospital during the period 1st
of January 2007 to 30th of June 2007.Eighty four
patients with presumptive diagnosis of meningitis<

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Publication Date
Sun Jun 01 2014
Journal Name
Baghdad Science Journal
Determination Oxidant - Antioxidant Enzyme and some Trace Elements in Breast Cancer in Baghdad City
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level of effectiveness of Glutathione - S - Transferees (GST), Glutathione peroxides (GPX),Malondialdehyde (MDA) the product of lipid peroxidation and some trace elements ( zinc,seleinum,iron ,copper ) had been measured in sera of (50) women with breast disease.which had been divided to : Control group (25),The first group (A) benign breast tumors (25),the second group (B) breast cancer (25). The results showed a clear moral high level of Glutathione - S - Transferees (GST), Glutathione peroxidase (GPX) , and Malondialdehyde (MDA) level in breast cancer group while a slight increase were observed in the levels of these enzymes and(MDA) in benign breast group. A significant reduction was evident in the levels of selenium and zinc

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Publication Date
Sun Sep 02 2012
Journal Name
Baghdad Science Journal
Benzoic acid concentration levels recovery in Ketchup and Sauce products available in local market.
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This research is dealing with five sample of tomato ketchup products available in local market that were respectively as follows: Hello-Baghdad Iraq, Tiffany-Abu Dhabi, Melody-Dubai, Baidar-Saudi Arabia, and Altunsa-Turkey. Also it is dealing with four sample of sauce products available in local market that were respectively as follows: Hello-Baghdad, Iraq, Al-Badawi-Baghdad Iraq, Family-Baghdad, Iraq, and Hala-Amman Jordon. Analysis was performed on each sample three times and mean of the reading was taking. Samples were tested through terse and shorthand from lengthened steps. The spectrophotometric method used rely on theoretical and practical bases in extraction and diagnosis by UV spectrophotometer. This method in short notes, consiste

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Publication Date
Sat Jan 01 2022
Journal Name
Bild Law Journal
Law and its influential role for strategic leadership in managing security crises in Iraq
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Publication Date
Sun Jun 12 2016
Journal Name
Iraqi Journal Of Market Research And Consumer Protection
Effect of food an appearance of ovaries cysts its relation with some variable factors in women at age 15-54 years in Baghdad – city: Effect of food an appearance of ovaries cysts its relation with some variable factors in women at age 15-54 years in Baghdad – city
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Abstract
This study aimed to kmow the effect of food on appearance of ovaries cyst in women aged 15-54 year in Baghdad. City and its relation ship with reproductive health Woman samples was divided to four aged groups;15-24 , 25-34 , 35-44 and 45-54 years.
Results demonstrate that all samples of women has varied level of obesity.
Also we are noticed that all samples of women has varied level of obesity.
Also we are noticed tgat is a relation ship between obesity and marriagestatas with the highest proportion of ovarian cystsin obese marriage woman reached to37.90% The percent of un married women which have obesity class // with ovarian cysts reached50% Results refer to found that %19-24 of married women had obortians and

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Publication Date
Mon Feb 14 2022
Journal Name
Journal Of Educational And Psychological Researches
The Educational dimensions of children's television programs in the light of the universal rights of child
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The research aims at determining the type of educational dimensions to be broadcasted in children's television programs, clarifying the technical forms used in children's TV programs, analyzing the educational dimensions provided by children's television programs, and studying the educational dimensions of children's television programs. The researcher used a sample of children's programs: all of us heroes, which is a daily program on the mbc3 channel as well as the program of Tel flowers on the Algerian channel. The researcher designed an analysis content form included categories of analysis. Spss program was used to process the collected data. The research reached several results; the concentration of educational dimensions in

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Publication Date
Wed Aug 07 2019
Journal Name
Iraqi National Journal Of Nursing Specialties
Evaluation of Nursing Performance Concerning Nasogastric Tube in Neonatal Intensive Care Unit at al-Batool Teaching Hospital in Baqubah City
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Objectives: The study aim to evaluate nursing performance during nasogastric tube feeding in neonatal intensive care unit. Methodology: A descriptive study was carried out in Neonatal Intensive Care Unit at al–Batool Teaching Hospital, for the purpose of evaluate of quality of nursing performance for premature baby during nasogastric tube feeding in neonatal intensive care unit. The study consumed the period from 4th of December 2017 to the 24nd of April 2018, Non-probability purposive sample of (25) nurses working in the neonatal intensive care unit. The data were collected through the use of Observational instrument which consist of socio-demographic characteristics, quality of nursing care. Results: The study shows that the majority

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