A number of disorders characterized by aberrant cell proliferation are referred to as cancers. Cancer is a complicated group of mutagenic diseases that can move or infiltrate to other parts of the body. It develops through a multi-step process. The need for new therapeutic strategies is driven by malignancies resistance to conventional therapies. Use of the Newcastle disease virus as an oncolytic agent has advanced and expanded in immunocompetent carcinoma tumor models by utilizing reverse genetics techniques. Preclinical investigations have shown that recombinant NDV (rNDV-GFP), which expresses foreign genes, is proven to be effective in cancer treatment. Green fluorescent protein gene is usually used as an expression reporter for certain genetically encoded molecular biomarkers. To demonstrate that a gene may be expressed in many organs, interest cells or across an organism, it was utilized to make GFP-expressing biosensors. GFP has been detected in human cells as well as bacteria, yeasts, fungi, fish and other animals. The aim was to investigate the anti-tumor effects of rNDV expressing GFP gene on U78-MG glioblastoma cell line in vitro. This research examined in vitro the anticancer activity of genetically modified Newcastle disease virus strains that express GFP (rClone3-GFP) using the MTT test (a colorimetric assay for measuring cell metabolic activity) on the U87-MG glioblastoma cell line. Recombinant viruses were found to be able to trigger a time-dependent demise of tumor cells death starting 96 hours after inoculation. Using reverse genetics, we inserted GFP-coding regions between the F and HN genes in the lentogenic NDVClone30 strain's genome which was named as rNDV-GFP. The recombinant NDV-GFP strains that produce GFP showed promising results for inhibiting growth of tumor cells. Our study paved the way for the use of recombinant NDV as an anticancer viral vector. Our results suggest that NDV-GFP is a promising therapeutic for glioblastoma cancer treatment.
This study focuses on the modeling of manufactured damper when used in steel buildings. The main aim of the manufactured dampers is to protect the steel buildings from the damaging effects that may result due to earthquakes by introducing an extra damping in addition to the traditional damping.
Only Pure Manufactured Dampers, has been considered in this study. Viscous modeling of damping is generally preferred in structural engineering as it leads to a linear model then it has been used during this study to simulate the behavior of the Pure Manufactured Damper.
After definition of structural parameters of a manufactured damper (its stiffness and its damping) it can be used as a structural element that can be added to a mathematica
The imbalances and economic problems which it face the countries, it is a result of international economic developments or changes or global crises such as deterioration in trade, sharp changes in oil prices, increasing global indebtedness, sharp changes in foreign exchange rates and other changes, all that, they affect the economic features of any country. and These influences vary from one country to another according to the rigidity of its economy and its potential in maneuvering with economic plans and actions that would reduce the impact or avoidance with minimal damage. Therefore, the countries that suffer from accumulated economic problems as a result of mismanagement and poor planning or suffe
... Show MoreIn this paper, a mathematical model consisting of harmful phytoplankton and two competing zooplankton is proposed and studied. The existence of all possible equilibrium points is carried out. The dynamical behaviors of the model system around biologically feasible equilibrium points are studied. Suitable Lyapunov functions are used to construct the basins of attractions of those points. Conditions for which the proposed model persists are established. The occurrence of local bifurcation and a Hopf bifurcation are investigated. Finally, to confirm our obtained analytical results and specify the vital parameters, numerical simulations are used for a hypothetical set of parameter values.
The study concentrated on measuring the lipid peroxidation marker malon di aldehyde (MDA) in sera of thirty five patients with minor Thalassemia (Tm), thirty five with major Thalassemia (TM) and thirty five healthy control, their age ranged from (17-30) years. Erythrocytes enzymes (Glutathione -S - transferase (GST )and Catalase) were assayed . The results showed a significant elevation in (MDA) in sera of both patient groups compared to control.
An increase in the activity of catalase and GST in erythrocytes of
minor Thalassemic patients compared to control was found to be significant. Also, a high significant increase in the
... Show MoreIn this paper, the topic of forecasting the changes in the value of Iraqi crude oil exports for the period from 2019 to 2025, using the Markov transitional series based on the data of the time series for the period from January 2011 to November 2018, is real data obtained from the published data of the Central Agency Of the Iraqi statistics and the Iraqi Ministry of Oil that the results reached indicate stability in the value of crude oil exports according to the data analyzed and listed in the annex to the research.
Keywords: Using Markov chains
This research dealt eith the effect of wars experienced bythe Iraqi people in the abroad Iraq women novels between 2003 – 2010, where this issye dominated on Iraqi women novels at this stage until it became the main subject that events revolved aroud in the novels of this stage.
The research also highlighted on the impact of continuous tough wars in human life and psyche, especially in the lives of women – and this is the privacy of feminist novel – where the Iraqi women novels focused on the impact of war on psychological of women and what it caused of misfortunes as women. Iraqi women have suffered from the bitterness of the loss caused by war as – any loss – a natural of her – the loss of father, son, husband, brother a
Leishmaniasis is a transmissible infection brought about by an obligatory intracellular protozoan from the genus Leishmania. It occurs worldwide in tropical and subtropical regions and can be burdensome in resource-constrained countries. The infection ranges in severity from mild cutaneous lesions to more severe and sometimes life-threatening visceral and distorting mucocutaneous sicknesses. Importantly, cutaneous leishmaniasis (CL) is prevalent in the Middle East with a pooled prevalence of 12%. It imposes a significant health and socioeconomic burden
In this work, we prove by employing mapping Cone that the sequence and the subsequence of the characteristic-zero are exact and subcomplex respectively in the case of partition (6,6,4) .
A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777×104 L.mol-1.cm-1. The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2. The propose
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