Interleukin-1 β (IL-1 β) is considered to be one of the most important mediators in the pathogenesis of inflammatory diseases, particularly in neurodegenerative diseases such as multiple sclerosis (MS). MS is a chronic inflammatory disease characterized with demyelination in central nervous system (CNS). There was believe that single nucleotide polymorphisms (SNPs) in IL-1β gene can alter the structure and function of the IL-1β and consequently may have play role in MS disease. In this this study the IL-1β gene polymorphism (rs16944, rs1143634) and their association with MS in Iraqi patients were investigated. Two SNPs including IL-1β-511 (rs16944) in promoter and IL-1B+3962 (rs1143634) in encoding region, were studied using Polymerase Chain Reaction- Sequence Specific Primer (PCR-SSP) technique. The results revealed that IL-1β-511 SNP has three genotypes (CC,CT, TT) with non- significant difference in the SNP genotype and allele frequencies of MS patients compare with control group, it was also noticed that the risk allele was (C) with relative risk (RR=1.55) and higher frequency (60.77%) than T (39.23%) allele in RRMS patients. On other hand the three genotypes (CC,CT, TT) of IL-1B+3962 SNP it seem to have the same picture, that mean there was no significant difference in their frequencies between RRMS patients and control group , and the highest genotype frequency was for (CC) genotype (68.92%) and the lowest frequency was for( TT) genotype (2.88%) in patients, it was also noticed that the risk allele was (C) with odd ratio (2.44) and that the (T) frequencies were (16.98%vs. 33.33%) while (C) frequencies were (83.02 vs. 66.67%) in patients and control group respectively. Concerning with these findings, one can suggest that interleukin-1β gene polymorphisms may not be relevant to susceptibility to MS in Iraqi patients, this is probably due to many reasons such as ethnic diversity, the relevant of haplotype for this gene with other haplotype of cytokine encoding genes and finally the limitation of sample size which play critical role in SNPs studies.
The present study was carried out on forty eight epididymis of sexually mature dogs to elucidate light microscope features and the presence of testosterone receptors inside epididymis in different seasons. Twenty four dogs aged 3 years were used during the periods from 1/2/2015-1/2/2016. The epididymis were carefully dissected from the testis after orchidectomy operations and fixed, dehydrated, clarified and embedded in paraffin. Sections were stained with hematoxylin and eosin and periodic acid schiff. As well as, paraffin embedded cytoimmunochemistry technique was used for detection of testosterone receptors. Muscular coats showed no significant differences during different seasons or among segments. Epithelial heigh
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The composition of fish assemblages in Iraqi marine water was assessed. 91 species belonging to 71 genes and 47 families of Osteichthyes and 13 species of Conderchthyes were collected during the study period from January to December 2018, using trawl net fishing. Three stations were selected, where two new species (Siganus javus and Gobiopsis sp.) and reclassification of Torpedo panthera where identified and two species of freshwater fish (Oreochromis niloticus and Oreochromis aureus) were first recorded in marine waters. The highest numbers of species were 32 and 42 for the first and second stations, respectively, recorded in October , while 55 species were recorded in the third s
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In this paper an improved weighted 0-1 knapsack method (WKM) is proposed to optimize the resource allocation process when the sum of items' weight exceeds the knapsack total capacity .The improved method depends on a modified weight for each item to ensure the allocation of the required resources for all the involved items. The results of the improved WKM are compared to the traditional 0-1 Knapsack Problem (KP). The proposed method dominates on the other one in term of the total optimal solution value of the knapsack .
Meerkat Clan Algorithm (MCA) is a nature-based metaheuristic algorithm which imitates the intelligent behavior of the meerkat animal. This paper presents an improvement on the MCA based on a chaotic map and crossover strategy (MCA-CC). These two strategies increase the diversification and intensification of the proposed algorithm and boost the searching ability to find more quality solutions. The 0-1 knapsack problem was solved by the basic MCA and the improved version of this algorithm (MCA-CC). The performance of these algorithms was tested on low and high dimensional problems. The experimental results demonstrate that the proposed algorithm had overcome the basic algorithm in terms of solution quality, speed a
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Background: Good Nutrition is essential for oral and dental health in children. Good eating habits and food preferences are established early in childhood. Oral health problems can effect dietary quality and nutrient intake in another side increase the risk of several systemic diseases., The aim of the present study was to investigate the relation or the effect the of nutritional status in children at age of 5 to16 on the oral health status and dental caries . Materials and Methods: the total sample composed of 153 patients attending the Pedodontic and Preventive Department/College of Dentistry/University of Baghdad, the assessment of nutritional status was performed by using Body Mass Index specific for age and gender according to Chronic
... Show MoreOut of 150 different specimens, 67 S. aureus isolate were isolated. However, 16sRNA gene was located only in 60 isolates. Moreover, mecA gene was located in 48 isolates; thereby MRSA covered 80% of all S. aureus isolates. Of considerable interest, pvl gene was detected in only six isolates (10%). Hence, the present work emphasizes the notion suggested that pvl is not an indicative of CA-MRSA.