MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. Transitional cell carcinoma(TCC) of the bladder Cancer (C) account 95 percent of bladder malignancies, with males having a greater prevalence than females. The current study sought to determine whether there is a link between miRNA-29c, miRNA-125, miRNA-141, miRNA-145 and miRNA205 expression levels and TCC/BC risk in Iraqi bladder cancer patients. In the current prospective cross-sectional investigation, 149 samples were collected (95 urine and 54 tissue biopsies). From November 2018 to August 2019, 37/95 urine samples were randomly taken from healthy persons. Total RNA was extracted from tissue and urine samples, and then converted to cDNA via reverse transcription. Quantitate Real-Time-PCR was done using specific primers for quantification of gene expression level of the studied miRNAs. The results showed that 32/49 (65%) patients had non-muscles invasive bladder cancer (stage T1), while 17/49 (35%) patients had muscles invasive bladder cancer (stage T2-T4). Fold change in miRNA-125 expression level showed highly significant differences between non-muscles invasive bladder cancer (T1) and muscles invasion bladder cancer (T2-T4) in both urine and tissue samples biopsies using Chi-square test at p ≤ 0.01. Whereas miR-29c, miR-141, miR-145 and miR-205 showed no significant differences at p > 0.05 between muscles invasive bladder cancer (T1) and muscles invasive bladder cancer (T2-T4) in both urine and tissue biopsies samples. Thus, miR-125 can be associated with the development of invasive stages of TCC-BC as there is an increase in miR-125 expression level in the urine of patients during the final stage of cancer.Hence, this gene could be considered a good predictor in advanced stages of bladder cancer.
Reinforced concrete (RC) beams containing a longitudinal cavity have become an innovative development and advantage for economic purposes of light-weight members without largely affecting their resistance against the applied loads. This type of openings can also be used for maintenance purposes and usage space of communication lines, pipelines, etc. RC beams are primarily loaded in the plane of the members, which are two-dimensional in a plane stress state and the dominant structural behaviours include bending, shear, or combination of both. In the present study, six numerical models of RC beams with and without openings were simulated by using commercial finite element software ANSYS to evaluate the structural behaviours of those b
... Show MoreBilinear interpolation and use of perceptual color spaces (HSL, HSV, LAB, and LUV) fusion techniques are presented to improve spatial and spectral characteristics of the multispectral image that has a low resolution to match the high spatial resolution of a panchromatic image for different satellites image data (Orbview-3 and Landsat-7) for the same region. The Signal-to-Noise Ratio (SNR) fidelity criterion for achromatic information has been calculated, as well as the mean color-shifting parameters that computed the ratio of chromatic information loss of the RGB compound inside each pixel to evaluate the quality of the fused images. The results showed the superiority of HSL color space to fuse images over the rest of the spac
... Show MoreA selective and sensitive spectrophotometric extraction method was established and used to estimate antihypertensive drug, losartan potassium. The method is based on the formation of blue ion pair of the anionic drug, losartan, and the cationic dye, methylene blue, at adjusted pH 6.5 in aqueous solutions, followed by quantitative extraction to dichloromethane;.The observed maximum absorbance was at π 654.9 nm. With 4.53321 x 105 M-1 cm-1 molar absorptivity, Beer's law was obeyed within a concentration range of 0.03-1.5 μg / ml. The limit of detection and the limit of quantification were 0.01μg / ml and 0.03μg / ml, respectively. The method's precision was estimated by a relative standard devi
... Show MoreAchieving a connection between sustainability processes and environmental protection, or what is known as sustainable development, requires paying more attention to environmental and sustainability issues for various projects and their effects on environmental problems. It involves determining the most appropriate ways to deal with them within pillars of sustainability (environmental, social, economic, and natural resources. As cement is a fundamental component of industrial services and construction in cities, it has a direct and significant interaction with the development process, making it one of the most important industries in Iraq. Because of the clinker particles and combustio
Light isotopes, especially closed shell nuclei, have significance in thermonuclear reactions of the Carbon-Nitrogen-Oxygen (CNO) cycle in stars. In this research, 12C(p, γ) 13N and 14N(p, γ) 15O reactions have been calculated by means of Matlab codes to find the reaction rate across a temperature range of 0.006 to 10 GK using non-resonant parts, as well as the astrophysical S- factor S(E) at low energies. It was concluded that the high binding energy of 12C and 14N nuclei make the reaction less probable thus enabling other competitive processes to develop, which enhances the probability of other competitive proton reactions in the CNO cycle.
The main purpose of this paper, is to characterize new admissible classes of linear operator in terms of seven-parameter Mittag-Leffler function, and discuss sufficient conditions in order to achieve certain third-order differential subordination and superordination results. In addition, some linked sandwich theorems involving these classes had been obtained.
In this work, Co-Y-oxide Nano Structure is successfully synthesized via hydrothermal method. The XRD analysis, SEM analysis, optical, electrical and photo sensing properties have been investigated for Co3O4 and Co-Y-oxide thin films. The X-ray diffraction (XRD) analysis reveals that all films are polycrystalline in nature, having cubic structure. The SEM images of thin films clearly indicates that Co3O4 possesses nanosphere like structure and flower like for Co-Y-oxide. The optical properties show that the optical energy gap follows allowed direct electronic transition calculated using Tauc equation and it increases for Co-Y-oxide. The photo sensing properties of thin films are investigated as a function of time at different wavelengths to
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