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Evaluating the in vitro anti-Leishmanial activity of essential oil extracted from Cymbopogon Citratus against Leishmania Donovani

    Leishmania is one of the protozoan parasites that are transferred to human by infected sand flies and gives rise to a range of diseases entitled as Leishmaniasis. More than 20 known species of Leishmania can infect humans and cause various clinical symptoms. Three most known clinical manifestations are Cutaneous Leishmaniasis (CL), Mucocutaneous Leishmaniasis (MCL) and Visceral Leishmaniasis (VL) (kala-azar or black fever). The difference in the clinical form dependent on several factors: species of Leishmania, type of vector that transmits the Leishmania, and the immune status of an infected individual. The current drugs which are used as anti-leishaminial treatment are characterized by enormous side effects, including their toxicity to human, long term treatment, liver problems and huge cost. Therefore, there is a necessity to find an alternative treatment marked as low cost, more specific against parasite’s stages, and metabolic pathways, and non-toxicity to human. Plants are considered one of the important sources for the remedy of the tropical diseases caused by bacteria, viruses, and parasites. Cymbopogon Citratus (lemon grass) is a herbal medicine used as anti-inflammatory, antibacterial, antifungal, anti-malarial, anti-protozoal and for gastrointestinal problems remedy. In order to detect the effects of C. Citratus against Leishmaniasis, in this study, serial dilution for the essential oil of C.citratus (1000, 500, 250, 125, 62.5 and 31.25) µg/ml were used against L. donovani Promastigotes. Viability was also evaluated at 24, 48 and 72 hours post-treatment. The results revealed that high concentrations (1000, 500 and 250) µg/ml were more effective than other concentrations during all time intervals, and IC50 values were 640, 492 and 442 µg/ml at 24, 48 and 72 hours respectively. In conclusion, this current study is one of a persistent search to find new treatments characterized by its high activity and low adverse effects to treat protozoa parasites for instance, Leishmania, and displays the effectiveness of the essential oils as a promising alternative

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Publication Date
Thu Dec 30 2004
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
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Publication Date
Wed Jan 01 2020
Journal Name
Biochemical & Cellular Archives
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Publication Date
Fri Nov 01 2024
Journal Name
Current Medicinal Chemistry
Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR Allosteric Site Inhibitors
Introduction:

Allosteric inhibition of EGFR tyrosine kinase (TK) is currently among the most attractive approaches for designing and developing anti-cancer drugs to avoid chemoresistance exhibited by clinically approved ATP-competitive inhibitors. The current work aimed to synthesize new biphenyl-containing derivatives that were predicted to act as EGFR TK allosteric site inhibitors based on molecular docking studies.

Methods:

A new series of 4'-hydroxybiphenyl-4-carboxylic acid derivatives, including hydrazine-1-carbothioamide (S3-S6) and 1,2,4-triazole (S7-S10) derivatives, were synthesized and characterized using IR, 1HNMR, 13CNMR

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Publication Date
Sun Oct 01 2023
Journal Name
Baghdad Science Journal
Effects of Water Stress, Nitrogen, Magnesium and their Interactions on Some Growth Characteristics and Essential Oil content of Rosemary (Rosmarinus officinalis L.)

A factorial experiment was applied with four replicates on rosemary plants (Rosmarinus officinalis L.) grown in pots inside the glasshouse of the Department of Biology, College of Science, Salahaddin University, Erbil, Iraq, during April, 2019 to July, 2020, to determine the effects of soil moisture content ( SM1: 100% and SM2: 60% field capacity), nitrogen fertilizer (N1: 100, N2: 200 and N3: 300kg/hectare), and magnesium fertilizer (Mg1: 0.0, Mg2: 30 and Mg3: 60kg/hectare) and their interactions on some growth characteristics  and essential oil content of rosemary plants. Two cuttings were taken from rosemary shoots (on March, 2020 and July, 2020) after 12 and 15 months of planting respectively. Results showed that cutting 1:

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Publication Date
Tue Jul 28 2020
Journal Name
Iraqi Journal Of Science
Antibacterial Activity of Silver Nanoparticles Synthesized from Plant Latex

     Nanoparticles produced by plants are preferred in the medical field for its safe and unpolluted product; it is also accepted as an ecofriendly, non-expensive, and non-toxic nanomaterial. In this study, silver nitrate was successfully used to produce silver nanoparticles (AgNPs) by the use extractsof 4 different latex-producing plants which belong to 2 families (Moraceae and Euphorbiaceae). The synthesis was proved by Atomic Force Microscopy (AFM).The sizes of the AgNP grains were estimated by Granularity Cumulating Distribution (GCD). The results revealed the production of AgNPs in different sizes of 103 and 82 nm using the Moraceae family and 77 and74nm using the Euphorbiaceae

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Publication Date
Fri Feb 03 2023
Journal Name
Nano Hybrids And Composites
Synthesis and Characterization of Nanoparticles Extracted from <i>Catharanthus roseus</i> Plant

The Catharanthus roseus plant was extracted and converted to nanoparticles in this work. The Soxhlet method extracted alkaloid compounds from the plant Catharanthus roseus and converted them to the nanoscale. Chitosan polymer was used as a linking material and converted to Chitosan nanoparticles using Sodium TriPolyPhosphate (STPP). The extracted alkaloids were linked with Chitosan nanoparticles CSNPs by maleic anhydride to get the final product (CSNPs- Linker- alkaloids). The synthesized (CSNPs- Linker- alkaloids) was characterized using SEM spectroscopy UV–Vis., Zeta Potential, and HPLC High-Performance Liquid Chromatography. Scanning electron microscope (SEM) analysis shows that the Chitosan nanoparticles (CSNPs) have small dim

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Publication Date
Sat Jun 04 2022
Journal Name
Al–bahith Al–a'alami
Digital public relations and its role in prioritizing the masses: An analytical study of the United Nations website : (A paper extracted from a PhD dissertation)

This paper aims to identify how the United Nations works through its website in prioritizing audiences towards international issues، by identifying the digital PR mechanisms used in digital PR contents in prioritizing audiences towards the international issues they deal with. To achieve the objectives of this paper, the researcher used the survey method and content analysis tool with a view to identifying the ranking of international issues on the website of health، peace and security، humanitarian assistance، human rights، women، migrants، refugees and displaced persons، economic development، United Nations affairs، culture and education، environment and climate، sustainable development, and law and crime prevention. One of

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Publication Date
Wed Mar 28 2018
Journal Name
Iraqi Journal Of Science
Essential-small Projective Modules

In this paper, we introduce the concept of e-small Projective modules as a generlization of Projective modules.

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Publication Date
Sat Jan 01 2022
Journal Name
International Journal Of Early Childhood Special Education (int-jecse)
Publication Date
Thu Dec 30 2021
Journal Name
Iraqi Journal Of Science
On P-Essential Submodules

Let  be a commutative ring with identity and let   be an R-module. We call an R-submodule  of  as P-essential if  for each nonzero prime submodule  of    and 0  . Also, we call an R-module  as P-uniform if every non-zero submodule  of  is P-essential. We give some properties of P-essential and introduce many properties to P-uniform R-module. Also, we give conditions under which a submodule  of a multiplication R-module  becomes P-essential. Moreover, various properties of P-essential submodules are considered.

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