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Evaluation of Chitosan-Alginate Nanoparticle as A Stable Antibacterial Formula in Biological Fluids
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      This research mainly focuses on the preparation of chitosan-alginate Nanoparticle by ionotropic gelation method using calcium chloride and sodium alginate to form nanocomposites of CH-ALg, examine their antibacterial activity against multidrug resistance (MDR) bacteria, and evaluate the stability of chitosan-alginate formula in different biological fluids, including simulated gastric fluid (SGF) and intestinal fluid (SIF). The average diameter of particles size prepared was measured by an Atomic force microscope (AFM) and it was 61.91 nm. Otherwise, the nature of functional groups present in CH-ALg nanoparticle was investigated by Fourier transforms infrared (FTIR) analysis. The stability of synthesized CH-ALg nanoparticle was measured by Zeta potential measurement and show high stability with a 79 mV ratio. The SEM picture shows that particles are shown to be in the form of bundles and the size of nanoparticles was in the range of (14-84nm). The antibacterial activity of CH-ALg was tested against (MDR) Gram-positive bacteria (staphylococcus aureus) and Gram-negative bacteria (Salmonella typhi, Pseudomonas aeruginosa, and Enterobacter cloacae). The results exhibited a significant impact of antibacterial action against isolates of MDR. CH-ALg nanoparticles were loaded with antibiotic doxycycline in order to strengthen the antibacterial action and drug delivery effectiveness. The synergistic effects of prepared CH-ALg loaded with DOX antibiotic at several concentrations toward MDR bacteria were also examined. The results indicate that DOX-loaded nanoparticles have a significant improvement for antibacterial activity against Gram-negative and Gram-positive compared to doxycycline alone. The formula of chitosan- alginate was stabile in various biological fluids including simulated gastric fluid (SGF) and simulated intestinal fluid (SiF)

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Publication Date
Sun Jul 30 2023
Journal Name
Iraqi Journal Of Science
Development of Low-Temperature Atmospheric Plasma Jet Sources for Biological Applications
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     The research aims to develop and build a plasma jet system operating under atmospheric pressure.for biological purposes. The advanced plasma system consists of a power supply and a plasma torch. The source of the development of the system is a previous laboratory system that was developed by changing the voltage and frequency of the power supply, as the power provider equips the system with a voltage in the form of a sine wave whose value is fixed at about (7.5kV) peak to peak and its frequency is about (28 kHz). The plasma torch consists of a teflon tube with of width of (10 m ) located at (10mm)  from the end of the tube. The current waveform and voltage wave were measured using a current and voltage sensor and an oscilloscop

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Publication Date
Sun Dec 25 2022
Journal Name
International Journal Of Drug Delivery Technology
Synthesis, Characterization of New Isatin-Ibuprofen Derivatives with Expected Biological Activity
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Ibuprofen is one of the most important members of NSAIDs, named aryl propionic acid derivative. Isatin (1H-indole-2,3-dione) is an important molecule of heterocyclic compounds that have many biological activities. This work illustrates the synthesis of new ibuprofen-isatin derivatives by connecting ibuprofen hydrazide with different isatin derivatives by a condensation reaction, followed by characterization by fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The anti-inflammatory activity was evaluated by using the egg-white induce edema method for all the synthesized compounds (5-8), the compounds 5 and 6 showed better anti-inflammatory activity than ibuprofen as a standard

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Publication Date
Wed Jul 01 2020
Journal Name
International Journal Of Pharmaceutical Research
Synthesis, Design, Docking and biological activity of new benzo hydrazide derivatives.
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Publication Date
Fri Dec 08 2023
Journal Name
Iraqi Journal Of Science
Inelastic longitudinal electron scattering C2 form factors in 48Ca nucleus by using sigma meson as a residual interaction.
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Inelastic longitudinal electron scattering C2 form factor in 48Ca has been utilized
to study the effects of fitting parameters on the sigma meson exchange type
potentials as a residual interaction. By coupling the core particles with model space
particle, where the latter used as an active part of residual interaction in the so called
core polarization process, it is included as a correction with first order perturbation
theory to the main calculation of model space, and the excitation energy has been
carried out with ( ). A model space wave vectors are generated in full fp shell
model with FPD6 as effective interaction with mixing configuration technique and
harmonic oscillator as a single particle wave function.

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Publication Date
Sat Jun 01 2013
Journal Name
Journal Of The College Of Basic Education
Beta-2-Microglobulin as a Biomarker in Iraqi Female Patients with Autoimmune Thyroid and Renal Autoimmune Thyroid Diseases
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The present study was performed on 80 female subjects between (30-60) years, who attended the Specialized Center for Endocrinology and Diabetes during the period from April to July; 2011. The subjects were divided into 3 groups : controls , non diabetic autoimmune thyroid patients , and non diabetic autoimmune thyroid patient with renal diseases as complication The results showed a significant increase in serum T 3 T4 levels in hyperthyroidism patients, and significant decrease in serum T3,T4 levels in hypothyroidism patients ,while a significant difference in serum TSH levels in hyperthyroidism and hypothyroidism patients when compared to control group The results show also a significant increase in serum antibodies to thyroid peroxidas

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Publication Date
Sun Sep 30 2012
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Polyvinyl Alcohol – Sodium Nitrite Water Soluble Composite as a Corrosion Inhibitor for Mild Steel in Simulated Cooling Water
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The inhibitive action of polyvinyl alcohol –sodium nitrite (PVASN) composite on the corrosion of mild steel in simulated cooling water (SCW) has been investigated by weight loss and potentiodynamic polarization. The effect of composite concentration (PVA/SN) , pH, and exposure time on corrosion rate of mild steel were verified using 2 levels factorial design and surface response analysis through weight loss approach, while the electrochemical measurements were used to study the behavior of mild steel in (SCW) with pH between 6 and 8 and in absence and presence of (PVA) in solution containing different concentration of NaNO2. It was verified that all three main variables studied were statistically significant while their interaction is

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Publication Date
Wed Dec 30 2015
Journal Name
Al-kindy College Medical Journal
Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycatedhaemoglobin as a dual biomarker
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Background: Patients with type 2 diabetes have an increased prevalence of lipid abnormalities, contributing to their high risk of cardiovascular diseases (CVD).Glycated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control. In accordance with its function as an indicator for the mean blood glucose level, HbA1c predicts the risk for the development of diabetic complications in diabetic patients[2].Apart from classical risk factors like dyslipidemia, HbA1c has now been regarded as an independent risk factor for (CVD) in subjects with or without diabetes.Objective The aim of this study was to find out association between glycaemic control (HbA1c as a marker) and serum lipid profile in type 2 diabetic patients.Methods

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Publication Date
Sat Sep 23 2023
Journal Name
Journal Of Cardiovascular And Thoracic Research
Plasminogen activator urokinase receptor as a diagnostic and prognostic biomarker in type 2 diabetic patients with cardiovascular disease
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Introduction: Cardiovascular diseases are the main cause of death among type 2 diabetic patients. Higher levels of plasminogen activator urokinase receptor have been found to predict morbidity and mortality across acute and chronic diseases in the common populace. This study aims to explore the role of serum plasminogen activator urokinase receptor levels as a cardiometabolic risk factor among type 2 diabetic Iraqi patients. Methods: Seventy type 2 diabetic patients (40 male and 30 female) (mean age: 46.20±7.56 years) participated in this study; 35 patients were with cardiovascular disease and 35 were without cardiovascular disease; their ages range was 40-55 years. In addition, 30 individuals who apparently healthy were selected a

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Publication Date
Thu Apr 01 2021
Journal Name
Biochemical And Cellular Archives
Design, Synthesis and Antibacterial Evaluoation of mutual Prodrugs of Antioxidants With Different quinolone Antibiotics
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Publication Date
Thu Nov 01 2018
Journal Name
Colloids And Surfaces B: Biointerfaces
Green synthesis of silver nanoparticles using turmeric extracts and investigation of their antibacterial activities
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