Clobetasol propionate (CP) is a super potent corticosteroid widely used to treat various skin disorders such as atopic dermatitis and psoriasis. However, its utility for topical application is hampered due to its common side effects, such as skin atrophy, steroidal acne, hypopigmentation, and allergic contact dermatitis. Microsponge is a unique three-dimensional microstructure particle with micro and nano-meters-wide cavities, which can encapsulate both hydrophilic and lipophilic drugs providing increased efficacy and safety. The aim of the current study is to prepare and optimize clobetasol-loaded microsponges. The emulsion solvent diffusion method is used for the preparation of ethylcellulose (EC)-based microsponges. The impact of

     The present study investigates the implementation of machine learning models on crop data to predict crop yield in Rajasthan state, India. The key objective of the study is to identify which machine learning model performs are better to provide the most accurate predictions. For this purpose, two machine learning models (decision tree and random forest regression) were implemented, and gradient boosting regression was used as an optimization algorithm. The result clarifies that using gradient boosting regression can reduce the yield prediction mean square error to 6%. Additionally, for the present data set, random forest regression performed better than other models. We reported the machine learning model's performance using Mea

The Digital Elevation Model (DEM) has been known as a quantitative description of the surface of the Earth, which provides essential information about the terrain. DEMs are significant information sources for a number of practical applications that need surface elevation data. The open-source DEM datasets, such as the Advanced Space-borne Thermal Emission and Reflection Radiometer (ASTER), the Shuttle Radar Topography Mission (SRTM), and the Advanced Land Observing Satellite (ALOS) usually have approximately low accuracy and coarser resolution. The errors in many datasets of DEMs have already been generally examined for their importance, where their quality could be affected within different aspects, including the types of sensors, algor

Free Space Optical (FSO) technology offers highly directional, high bandwidth communication channels. This technology can provide fiber-like data rate over short distances. In order to improve security associated with data transmission in FSO networks, a secure communication method based on chaotic technique is presented. In this paper, we have turned our focus on a specific class of piece wise linear one-dimensional chaotic maps. Simulation results indicate that this approach has the advantage of possessing excellent correlation property. In this paper we examine the security vulnerabilities of single FSO links and propose a solution to this problem by implementing the chaotic signal generator “reconfigurable tent map”. As synchronizat

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Abstract. Full-waveform airborne laser scanning data has shown its potential to enhance available segmentation and classification approaches through the additional information it can provide. However, this additional information is unable to directly provide a valid physical representation of surface features due to many variables affecting the backscattered energy during travel between the sensor and the target. Effectively, this delivers a mis-match between signals from overlapping flightlines. Therefore direct use of this information is not recommended without the adoption of a comprehensive radiometric calibration strategy that accounts for all these effects. This paper presents a practical and reliable radiometric calibration r

An experimental study is conducted to investigate the effect of heat flux distribution on the boiling safety factor of its cooling channel. The water is allowed to flow in a horizontal circular pipe whose outlet surface is subjected to different heat flux profiles. Four types of heat flux distribution profiles are used during experiments: (constant distribution profile, type a, triangle distribution profile with its maximum in channel center, type b, triangle distribution profile with its maximum in the channel inlet, type c, and triangle distribution profile with its maximum in the channel outlet, type d). The study is conducted using heat sources of (1000 and 2665W), water flow rates of (5, 7 and 9 lit/min). The water