Dysregulation of matrix metalloproteinases-9 (MMP-9) and tissue inhibitors of
matrix metalloproteinases-1 (TIMP-1) may contribute to the development of
cardiovascular diseases in type 2 diabetes mellitus (T2DM) patients. The aim of this
study was to determine the effects of chronic hyperglycemia on serum
concentrations of MMP-9 and TIMP-1of T2DM patients without dyslipidemia (one
of atherosclerosis risk factors) and with duration less than 5 years in comparison
with T2DM patients with dyslipidemia and with duration more than 10 years and
controls. Also to investigate if serum levels of MMP-9 and TIMP-1 could be
potential markers for early detection of the development of cardiovascular
complications in T2DM patients without dyslipidemia. This study consisted of 24
T2DM patients without dyslipidemia, 30 T2DM patients with dyslipidemia, and 26
healthy subjects. A variety of inflammatory markers including: MMP-9, TIMP-1,
IL18 and hs-CRP were compared among the three groups. The BMI was similar
among the three groups. A significant increase of WHR, WHtR, FPG, TC, TG,
LDL-C, VLDL-C, AIP, atherogenic ratio-1, atherogenic ratio-2, hs-CRP, MMP-9,
TIMP-1 and IL-18 with a significant decrease of HDL-C, β Cell% and S% among
the three groups. MMP-9 of T2DM patients without dyslipidemia and with duration
less than 5 years showed a significant positive correlation with FPG and a
significant negative correlation with TC. MMP-9 of T2DM patients with
dyslipidemia and with duration more than 10 years showed significant negative
correlation with LDL-C. TIMP-1 of T2DM patients with dyslipidemia and with
duration more than 10 years showed a significant negative correlation with TC, TG,
VLDL-C and atherogenic ratio-1. The significant increased levels of both MMP-9
and TIMP-1 in T2DM patients without dyslipidemia and with duration less than 5
years compared to controls showed that those patients have risk factor for
cardiovascular complications. This study suggests that MMP-9 and TIMP-1 may be
potentially useful as markers in T2DM patients at risk of progression of
cardiovascular diseases.
The problem of Bi-level programming is to reduce or maximize the function of the target by having another target function within the constraints. This problem has received a great deal of attention in the programming community due to the proliferation of applications and the use of evolutionary algorithms in addressing this kind of problem. Two non-linear bi-level programming methods are used in this paper. The goal is to achieve the optimal solution through the simulation method using the Monte Carlo method using different small and large sample sizes. The research reached the Branch Bound algorithm was preferred in solving the problem of non-linear two-level programming this is because the results were better.
The ground state proton momentum distributions (PMD) and elastic charge form
factors for some odd 1f 2p shell nuclei, such as , , 59 63Co Cu and Cu 65 have been
studied using the Coherent Density Fluctuation Model and formulated by means of
the fluctuation function (weight function) ( ) .
2
f x The fluctuation function has been
connected to the charge density distribution of the nuclei and determined from the
theory and experiment result. The feature of the long-tail behavior at high
momentum region of the PMD has been calculated by both the theoretical and
experimental fluctuation functions. It is found that the inclusion of the quadrupole
form factors ( ) 2 F q C in all nuclei under study, which are de
The problem of slow learning in primary schools’ pupils is not a local or private one. It is also not related to a certain society other than others or has any relation to a particular culture, it is rather an international problem of global nature. It is one of the well-recognized issues in education field. Additionally, it is regarded as one of the old difficulties to which ancient people gave attention. It is discovered through the process of observing human behaviour and attempting to explain and predict it.
Through the work of the two researchers via frequent visits to primary schools that include special classes for slow learning pupils, in addition to the fact that one of the researcher has a child with slow learning issue, t
In this research, the nonparametric technique has been presented to estimate the time-varying coefficients functions for the longitudinal balanced data that characterized by observations obtained through (n) from the independent subjects, each one of them is measured repeatedly by group of specific time points (m). Although the measurements are independent among the different subjects; they are mostly connected within each subject and the applied techniques is the Local Linear kernel LLPK technique. To avoid the problems of dimensionality, and thick computation, the two-steps method has been used to estimate the coefficients functions by using the two former technique. Since, the two-
... Show MoreThe study focused on the treatment of real oilfield produced water from the East Baghdad field affiliated to the Midland Oil Company (Iraq) using an oil skimming process followed by a coagulation/flocculation process for zero liquid discharge system applications. Belt type oil skimmer was utilized for evaluating the process efficiency with various operating conditions such as temperature (17-40 °C) and time (0.5-2.5 hr.). Polyaluminum chloride (PAC) coagulant and polyacrylamide (PAM) flocculant was used to investigate the performance of the coagulation/flocculation process with PAC dosage (5-90 ppm) and pH (5-10) as operating conditions. In the skimming process, the oil content, COD, turbidity, and TSS decreased with an increase in tempera
... Show MoreIbn al-Anbari, however, turned to Abu Hatim al-Sijistani in eleven places of his book ((clarify the endowment and start)). The study showed that the right and right was with the son of Anbari and that what went to Sistani saying uniqueness, and contrary to the vast majority of scientists. The study also showed that the science of grammar affects the endowment and initiation, as the study showed that the science of endowment and initiation is one of the important sciences of the Koran, which must be carefully received, researchers.
This work aims to investigate the integrated ultra-dense wavelength division multiplexing (UDWDM) and polarization division multiplexing (PDM) schemes incorporated in the free space optic (FSO) communication system. Erbium-doped fiber amplifiers (EDFAs) are used as post and pre-amplifiers in the proposed UDWDM–PDM–FSO system to boost the transmission power for increasing the distance. Thirty-two channels are transported over the FSO link to realize the total data transmission of 160 and 320 Gbps with 0.08 and 0.1 nm channel spacing, respectively. Results are also reported with non-return to zero modulation schemes. The performance of the proposed UDWDM–PDM–FSO transmission sys