This research was conducted to measure the safety of heat stable enterotoxin a (STa) produced by enterotoxigenic Escherichia coli, through studying its toxic effect on human blood lymphocyte, since it showed a promising effect in reducing the proliferation of colorectal cancer cells. the cytogenetic effects of (STa) by using five different concentrations (100, 200, 400, 800 and 1600μg/ml) in comparison with negative (PBS, Phosphate buffer saline) and positive (MMC, Mitomycin C) at concentration of 5μg/ml, controls on human blood lymphocytes obtained from both (10) normal healthy persons and (20) colorectal cancer patients was measured by employing the following parameters: mitotic index, blast index, chromosomal aberrations and micronucleus. On the human blood lymphocytes obtained from normal healthy persons, results showed that STa, and within all the different used concentrations, did not cause any significant cytogenetic changes in the all studied cytogenetic parameters. While on the human blood lymphocytes obtained from patients with colorectal cancer, STa was shown to cause significant decrease in both mitotic and blast index, and especially at both concentrations of (800 and 1600μg/ml) and this decrease was concentration dependent, but at the same time non significant changes were seen in both chromosomal aberrations and micronucleus parameters and for the all used concentrations. However, reduced mitotic and blast index and induced chromosomal aberrations and micronucleus frequencies of human blood lymphocytes that were obtained from both normal healthy persons and colorectal cancer patients, were observed after treatment with MMC.
Suicidal ideation is one of the severe mental health issues and a serious social problem faced by our society. This problem has been usually dealt with through the psychological point of view, using clinical face to face settings. There are various risk factors associated with suicides, including social isolation, anxiety, depression, etc., that decrease the threshold for suicide. The COVID-19 pandemic further increases social isolation, posing a great threat to the human population. Posting suicidal thoughts on social media is gaining much attention due to the social stigma associated with the mental health. Online Social Networks (OSN) are increasingly used to express the suicidal thoughts. Recently, a top Indian actor industry took th
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In this paper, we introduce the concepts of higher reverse left (resp.right) centralizer, Jordan higher reverse left (resp. right) centralizer, and Jordan triple higher reverse left (resp. right) centralizer of G-rings. We prove that every Jordan higher reverse left (resp. right) centralizer of a 2-torsion free prime G-ring M is a higher reverse left (resp. right) centralizer of M.
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Environmental controls, especially for temperature and humidity, are essential to maintain the safety, purity and effectiveness of drugs. The measurement of humidity can be particularly difficult and important in climatic and thermostatic chambers (warehouses, ovens, cold rooms, fridges, drying rooms, insulated boxes, etc.).
The old method of monitoring and qualification of climatic and thermostatic chambers requires placing a defined number of recorders, then programming and store them. After that, to examine the values recorded to revolve the status of the climatic and thermostatic chambers, if they are compliant or not-complaint at any time, so all that goes to waste time and efficiency of values.
We can do the monitoring and qu
God Almighty put in his great book secrets that do not end, and wonders that do not expire, for he is the one from which the scholars are not satisfied, and he does not create due to the multitude of response, and it is the comprehensive and inhibitory book that God conceals to the worlds, and he challenged the two heavyweights to come up with something like it.
At all times, issues arise in the Noble Qur’an that fit the needs of the people of that time and their culture, for it is an eternal book, characterized by the ability to give, extend and respond to addressing the problems of the age and its variables, when the Arabs had little luck at the time of the message’s descent from the scientific culture, and their proficienc
... Show MoreConsistent "with the thought of tax talk is unified tax natural evolution for him, as the application leads to the inclusion of tax all branches of income and its sources and through truncated part of this entry through the application of price ascending it, it means the procedures of tax reform. Taxes on total income characterized by giving a clear picture of the total income of the taxpayer and its financial situation and its burden family which allows granting exemptions, downloads, and application of prices that fit this case. This requires reconsideration of the structure of the tax system in force and the transition from a system specific taxes to the tax system on the total income of the integration of income from the rental of re
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This study concerns the isolation of oil degraded bacterial samples from oil polluted soil in Al-Dora refinery/ Baghdad – Iraq. Soil samples (15) were on mineral salt agar medium (MSM) used to screen the oil degrading bacteria by forming clear zones around the colonies. To confirm the degradation of oil by these bacteria, the isolates were inoculated in mineral salt broth, 15 isolates of Pseudomonas spp. was detected from which two isolates identified as P. aeruginosa by morphological, physical and biochemical characteristics that confirmed by using Vitick identification system. Growth was estimated in terms of whole cell by measuring optical density at 620 nm and free extract protein was estimated by protein measurement with Folin phe
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