The main process, for the elimination of cholesterol from the human body, involves the alteration of cholesterol into bile acid (BA), by the liver. The farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, is essential for the regulation of BA, glucose, and lipid metabolism. It is largely found in the liver, intestines, kidney, and adrenal glands, and to a smaller degree in the heart and adipose tissue. The binding locations, of the FXR, are in close proximity to formerly undisclosed target genes, with distinctive activities associated with transcriptional regulators, autophagy, apoptosis, hypoxia, inflammation, RNA processing, and a number of cellular signaling pathways. The preservation of BA homeostasis, by the FXR, entails the direct stimulation of the expression of the small heterodimer partner in the liver, and the fibroblast growth factor 15/19 (FGF15/FGF19) in the intestine, which impedes the activity of enzymes associated with hepatic BA synthesis, including cytochrome P450 7A1 (Cyp7a1). This investigation delves into the role of the FXR in terms of BA metabolism regulation, as well as its role in the pathophysiologic activity of cholestasis. © The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2024.
The purpose of this study is to measure doses delivered at different depths in water phantom at vertical position in comparison with the actual planning in order to verify the dose delivered to the tumor in addition to the measurement of the effect penumbra dose to assess the dose leaking to the healthy soft tissue.
Percentage depth dose (PDD) values was measured at field sizes (5×5,10×10,15×15, and 20×20) cm2, and the depth dose was measured between (0-16) cm deep at 4cm intervals, for both energies 6 MeV and 10 MeV X-ray beam. Other readings were taken at different distances 1cm and 2cm outside of the actual beam in orthogonal directions at depth of 4 cm. These measurements we
... Show MoreThe present study was used 20 adult male rats that distributed to four groups (each group consist 5 rats); control group that administrated normal saline, rats group that exposure to X ray for two weeks, rats group that exposure to X ray with 50ug of green silver nanoparticles for two weeks, rats group that exposure to X ray with 100ug of green silver nanoparticles for two weeks. The results show high significant increased (P < 0.01) in levels of malonedialdehyied (MDA), and high significant decreased (P < 0.01) in levels glutathione (GSH) and significant increased (P < 0.01) in levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), compared with control group. Histological sectio
... Show MoreIn this work Different weight of pure Zinc powder suspended particles in 4ml base engine Oil were used.
Intensity of Kα Line was measured for the suspended particles ,also for mixture which consist from Zinc particle blended with Engine base Oil. Calibration Curve was drawn between Ikα line Intensity and Zinc concentration at different operation condition. The Lower Limit detection (LLD) and Sensitivity (m) of Spectrometer were determined for different Zinc Concentration (Wt%). The results of LLD and m for Samples were analyzed at Operation Condition of 30KV,17mA is best from Samples were analyzed at Operation Condition of 25KV,15mA
The core objective of this study was to investigate the physicochemical characteristics and fatty acid composition of the oils of sunflower, olive, virgin coconut and ginger oils, as well as the separation of their unsaturated fatty acids. The data indicated a significant variation in physicochemical properties (acid, saponification, ester, and iodine values) among oils. Transesterification process was carried out at a molar ratio of 1:7:0.1 of oil: methanol: KOH. Fatty acid methyl esters of oils were analyzed by infrared (IR) and gas chromatography–mass (GC-MS) spectrometry. Twelve fatty acids were identified, where the major fatty acid of olive oil was found to be oleic acid (89%), whereas those of sunflower and ging
... Show MoreSamples of tea leaves (Green tea, Gugarate tea and Black tea used commonly in Iraq) are dried, grinded, pressed and submitted for the elemental analysis by x-ray fluorescence technique (XRF). The concentrations of major, minor and trace elements are determined. The major elements were Na, Mg, Al, K, Si, Ca, Mn, Fe, S and P. Of these elements, Ca, concentration in Gugarate tea leaves is three times, it's level in the other types of tea. Titanium, Cl, Rb and Sr are found as minor elements, while other elements such as Cu, Zn, V, Cr, Co, ...etc are found as trace elements. Of these trace elements considerable concentration values are found for some toxic elements Hg, Cd, Pb and As. Green tea contains 1.1 ppm Hg and 4.4 ppm Pb. Gugarate tea
... Show More<p>Combating the COVID-19 epidemic has emerged as one of the most promising healthcare the world's challenges have ever seen. COVID-19 cases must be accurately and quickly diagnosed to receive proper medical treatment and limit the pandemic. Imaging approaches for chest radiography have been proven in order to be more successful in detecting coronavirus than the (RT-PCR) approach. Transfer knowledge is more suited to categorize patterns in medical pictures since the number of available medical images is limited. This paper illustrates a convolutional neural network (CNN) and recurrent neural network (RNN) hybrid architecture for the diagnosis of COVID-19 from chest X-rays. The deep transfer methods used were VGG19, DenseNet121
... Show MoreThe thermal properties (thermal transfer and thermal expansion coefficient) of the enhanced epoxy resin (MWCNT / x-TiO2) were studied by weight ratios with the values (0%, 3%, 5%, 7% and 10%) and a constant ratio of 3% of MWCNT. The ultrasonic technology was used to prepare the neat and composites which were then poured into Teflon molds according to standard conditions. Thermo-analyzer sensor technology was used to measure thermal transfer (thermal conductivity, thermal flow, thermal diffusion, thermal energy and heat resistance). The thermal conductivity, flow, and thermal conductivity values were increased sequentially by increasing the weight ratio of the filler while the results of stored energy values an
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