Abstract Liver cancer with hepatocellular carcinoma a serious clinical illness that progresses quickly and has a bad prognosis because to increased malignancy. Fibrosis is the precursor of liver cancer, which progresses to cirrhosis and carcinoma Diethylnitrosamine (DEN) is a chemical molecule that has been used as a carcinogenic agent to promote cancer in test animals because of its strong carcinogenic potential. Herbal plants have long been used as inexpensive, effective alternatives to pharmaceuticals in various liver-associated complications, since they contain many bioactive compounds useful in liver disorders. Hibiscus tiliaceus L. (Malvaceae) contain various phytochemicals in the plant extracts such as Flavonoids, phenols, alkaloids, Tannins, Saponins, Quinones, Coumarine, Triterpenoids, glycosides and Steroids. Thus, has various health benefits, and have medicinal and therapeutic values, It could be a source of natural antioxidants, antimicrobials, hepatoprotective compounds, and antimutagenic effects. The study was designed To study the possible protective role of Iraqi Hibiscus tiliaceus L. ethanol leaves extract administered in two different doses on diethylnitrosamine induced liver carcinoma in male Wistar Albino rats. Rats utilized in this study were randomized into 4 groups (six rats per each group); Group I: (Control) Rats were administered oral daily dose of 1ml /kg/day of distilled water for 20 weeks; Group II: rats intraperitoneally injected with 70 mg/kg diethyl nitrosamine once per week for 10 continuous weeks; Group III: Rats were administered 250mg/kg of Iraqi Hibiscus tiliaceus L. ethanol leaves extract as chronic oral administration with food for 5 days per week for 20 weeks and subsequently intraperitoneal dose of diethylnitrosamine (70 mg/kg) once per week for 10 continuous weeks; Groups IV: Rats were administered 500mg/kg of Hibiscus tiliaceus L. ethanol leaves extract as chronic oral administration with food for 5 days per week for 20 weeks with subsequently intraperitoneal dose of diethylnitrosamine (70 mg/kg) once per week for 10 continuous weeks. The finding revealed that Iraqi Hibiscus tiliaceus L. ethanol leaves extract showed significant reduction (P<0.05) in malondialdehyde, alpha fetoprotein (AFP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), total bilirubin (TSB), pro-inflammatory cytokines include transforming growth factor beta (TGFβ), tumor necrosis factor alpha (TNFα) and significant elevation (P<0.05) of anti-oxidant enzyme superoxide dismutase (SOD) in dose dependent manner. In conclusion this study demonstrated that the chemoprotective role of Hibiscus tiliaceus L. ethanol leaves extract might be explained by; lowered levels of hepatic enzymes, pro-inflammatory cytokines, and antioxidant levels, as well as decreased levels of alpha fetoprotein (AFP), the gold standard for detecting hepatocellular carcinoma.
In-vitro biological activities of the free new H4L ( indole-7-thiocarbohydrazone) ligand and its Ni(II), Pd(II) , Pt(II), Cu(II), Ag(I), Zn(II) and Cd(II) complexes are screened against two cancerous cell lines, that revealed significant activity only for [Cu2Cl2(H4L)2(PPh3)2] after 72 h treatment by the highest tested concentrations. The Copper(I) complex was characterized by X-ray Crystallography and the NMR spectra, whereas it has been confirmed to have momentous cytotoxicity against ovarian, breast cancerous cell lines (Caov-3, MCF-7). The apoptosis-inducing properties of the Cu(I) complex have been investigated through fluorescence microscopy visualization, DNA fragmentation analysis and propidium iodide flow cytometry.
Some types of the fungus Aspergillus were isolated from some hospitals in the city of Baghdad (Imam Ali Hospital and Sadr General Hospital). The samples were taken by Transport media at a rate of three replicates of each place isolated from samples from different places within the hospital (waste, baths, the sick beds, corridors and room floors) for the purpose of isolating and diagnosing the fungus on the Czapeck Dox Agar media. It was noticed that the spread rate of fungus Aspergillus was 70% compared to other species that have emerged during the isolation process of the Sabouraud's Dextrose Agar media. The species A.niger (56.25%) was considered the most common type of fungus visible during the isolation process of the Imam Ali Hospit
... Show MoreThe research aim to measure the impact of the Industry specialization of the auditors on the quality in audit in Iraqi auditing firms, as well as measuring the factors of Industry specialization in the Iraqi audit companies by measuring the market shares of Iraqi audit firms that audit the companies listed on the Iraqi Stock Exchange For 2010 to 2016, by surveying the opinions of (35) Audit firm on the impact of the Industry specialization of auditing firms in audit quality factors, The effect of the variables was revealed through the use of the survey form Distributed to Iraqi audit companies, The industry speci
... Show MoreThe experiment was conducted in the glass house in a nursery at the growth season 2013.The experiment was designed by the Completely Randomized Blocks Design(CRBD).The seeds of two varieties of eggplant were studied.They were : 1.Lot (Number)Melaneana an American species,2.Aydinsiyah a Turkish species.We used three periods of water stress(1,8 ,16)days respectively, and three concentrations of proline acid (0,50,100) ppm using three frequents for each treatment.The experiment contained 54 experimental unit.The seeds were planted on the 30th/8/2013 in the glass house of the nursery, a month later, we put the plantelet in pots with good fertilized soil in the glass house.Some growth features were
... Show MoreA pots experiment was conducted in the plastic house of Kalar Horticulture station Province of Sulaimania, by using soil brought from one of Kalar region fields during growing season of 2007-2008, to study the effect of increasing levels of urea fertilizer which is (0, 0.20,0.40,0.80) g/pot which equals to (0,100,200,400) kg urea/ha, and super phosphate fertilizer which is (0,0.24,0.48)gm/pot which is equal (0,120,240) kg sup/ha, in nutrition state of wheat IPA 95 component, clay determining Nitrogen, Phosphor and Potassium content in green part and seeds. The Completely Randomized Design was used with three replication per t
... Show MoreTwo years field experiment was carried out at Agricultural Fields, College of Agriculture, Baghdad University, Al-Jadriya during 2014-2015 and 2015-2016 to determine the effect of salinity of irrigation water on growth and grain yield of three oat cultivars. The experiments were laid out according to randomized complete blocks design having split plot arrangements with two factors; first factor included three oat cultivars (Shifaa, Hamel and Pimula) while the second factor included three levels of salinity of irrigation water (3, 6 and 9 dS.m-1 ) in addition to the control (river water with salinity level of 1.164 dS.m-1 ) with three replicates. Results revealed a significant effect of salinity of irrigation water on all studied traits. Mea
... Show MoreThe present study was conducted to determine the effect of different concentrations of putrescine and spermidine at all stages of regeneration (callogenesis, somatic embryos multiplication, germination and rooting)) of date palm cultivar Barhee. Shoot tips were eradicated from 2-3 years old offshoots, surface sterilized and inoculated onto Murashiege and Skoog, 1962 (MS) medium supplemented with 20 mg/L 2,4-D and 3 mg/L N6-2-isopentyl adenine (2ip). Primary callus was obtained after 24 weeks on the nutrient medium. Calli were then transferred onto fresh MS medium containing 0.0, 50, 100 or 150 mg/L of putrescine or spermidine individually. Results were recorded after 12 weeks. A significant increase in embryonic callus fresh weights reached
... Show MoreA biological experiment was conducted in the field of Biology Department-College of Education (Ibn Al-Haitham) University of Baghdad for growing season of (2004-2005), to study the effect of two varieties of the fenugreek plant (Trigonella foenum – graeccum L.) and gibberellic acid concentration (0, 25, 50, 100, 125) part per million and duration of four spraying (15, 20, 25, 30) day determining concentration medicinal active saponine compounds like (Trigonelline, choline, Carpaine and Gentianine). The experiment was performed according to complete Randomize Complete Blocks Design (RBCD) by three replicate was adopted, means were compared by using the least significant difference at (0.05) probability level. Results showed t
... Show MoreA biological experiment was conducted to study the effect of different concentrations of gibberellic acid and urea fertilizer and their interactions in some characteristic related to green growth of fenugreek plant (Trigonella foenum-graecum L.) in the green house of Department of Biology in College of Education (IbnÂalÂHaitham)/Baghdad University for the growth season (2008Â2009) in pots of (5 kgm) soil per pot, and four concentrations of gibberellic acid were used, they are (0,25,50,100) ppm, these concentrations were sprayed after the perfection of the fourth leaf for the plant. Moreover, three levels of urea fertilizer were used, they were (0.25, 0.50, 1.00) gm/pot. These concentrations were added as two p
... Show MoreSome structures such as tall buildings, offshore platforms, and bridge bents are subjected to lateral loads of considerable magnitude due to wind and wave actions, ship impacts, or high-speed vehicles. Significant torsional forces can be transferred to the foundation piles by virtue of eccentric lateral loading. The testing program of this study includes one group consists of 3 piles, four percentages of allowable vertical load were used (0%, 25%, 50%, and 100%) with two L/D ratios 20 and 30, vertical allowable load 110 N for L/D = 20 and 156 N for L/D = 30. The results obtained indicate that the torsional capacity for pile group increases with increasing the percentage of allowable vertical load, when the percentage of allowable vertica
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